ERBB3 Protein (AA 20-643) (Fc Tag)
Quick Overview for ERBB3 Protein (AA 20-643) (Fc Tag) (ABIN6938840)
Target
See all ERBB3 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 20-643
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Purification tag / Conjugate
- This ERBB3 protein is labelled with Fc Tag.
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Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
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Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) protein (His-Avi Tag)
ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) (Active) protein (hFc Tag)ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-641) (Active) protein (His tag)ERBB3 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) protein (His tag)ERBB3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) (Active) protein (Biotin,His-Avi Tag)ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 544-643) protein (mFc Tag)ERBB3 Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 544-643) protein (Fc Tag)ERBB3 Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-331) protein (GST tag)ERBB3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1005-1230) protein (His tag)ERBB3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) protein (hIgG-His-tag)ERBB3 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Storage
- -20 °C
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- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
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Alternative Name
- ErbB3
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Background
- ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
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Molecular Weight
- 95.5 kDa
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NCBI Accession
- NP_001973
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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