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Browse our anti-PTK2B (PTK2B) Antibodies

Full name:
anti-PTK2B Protein tyrosine Kinase 2 beta Antibodies (PTK2B)
On www.antibodies-online.com are 242 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antibodies from 25 different suppliers available. Additionally we are shipping PTK2B Kits (19) and PTK2B Proteins (11) and many more products for this protein. A total of 289 PTK2B products are currently listed.
Synonyms:
Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, Pyk2, Rac, Raftk
list all antibodies Gene Name GeneID UniProt
PTK2B 24185 P47196
PTK2B 11651 P31750
PTK2B 2185 Q14289

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Top referenced anti-PTK2B Antibodies

  1. Human Polyclonal PTK2B Primary Antibody for IF, IHC (p) - ABIN196952 : Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004 (PubMed)
    Show all 5 references for ABIN196952

  2. Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705 : Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004 (PubMed)
    Show all 3 references for ABIN1724705

  3. Human Polyclonal PTK2B Primary Antibody for IF, IHC (p) - ABIN197440 : Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 references for ABIN197440

  4. Human Polyclonal PTK2B Primary Antibody for ELISA, WB - ABIN1533144 : Lev, Moreno, Martinez, Canoll, Peles, Musacchio, Plowman, Rudy, Schlessinger: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. in Nature 1995 (PubMed)
    Show all 2 references for ABIN1533144

  5. Human Polyclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1532112 : Herzog, Nicholl, Hort, Sutherland, Shine: Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization. in Genomics 1997 (PubMed)
    Show all 2 references for ABIN1532112

  6. Chicken Polyclonal PTK2B Primary Antibody for WB - ABIN2779801 : Ling, Sheng, Braun: The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation. in American journal of physiology. Cell physiology 2004 (PubMed)

  7. Human Polyclonal PTK2B Primary Antibody for IF (p), IHC (p) - ABIN745763 : Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015 (PubMed)

More Antibodies against PTK2B Interaction Partners

Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Antibodies)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Antibodies) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

  2. At fertilization, Pyk2 and p-Pyk2 were detected predominantly in sperm heads and the oocyte cytoplasm. Upon formation of male and female pronuclei, Pyk2 and its activated form accumulate in the two pronuclei. Pyk2 was in blastomere nuclei and the pre-blastula cytoplasm. Pyk2 and its activated form then localized to the perinuclear regions, where blastula cells come into contact with each other.

  3. the activation of ERK5 (show MAPK7 Antibodies)-AKT (show AKT1 Antibodies)-FoxO3a (show FOXO3 Antibodies) signaling pathways by fluid shear stress resulted in a decreased expression of FasL (show FASL Antibodies) and Bim (show BCL2L11 Antibodies) and an inhibition of caspase-3 (show CASP3 Antibodies) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  4. Only when suboptimal doses of Akt (show AKT1 Antibodies)-Pdpk1 (show PDPK1 Antibodies) interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Antibodies) inhibition was seen. We conclude that the Akt (show AKT1 Antibodies) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Antibodies) signaling.

  5. BAY 1125976 is a potent and highly selective allosteric AKT1 (show AKT1 Antibodies)/2 inhibitor.

  6. These findings indicated that VPA's neuroprotective effect in the MPP(+)-model of Parkinson's disease is associated with GSK3beta (show GSK3b Antibodies) phosphorylation via Akt (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) activation in the mitochondrial intrinsic apoptotic pathway.

  7. PLIO treatment inhibited nuclear factorkappaB (NFkappaB) nuclear translocation in B16F10 cells. In addition, PLIO treatment inhibited the phosphorylation of c-Jun (show JUN Antibodies) Nterminal kinases and AKT (show AKT1 Antibodies)

  8. this study shows that Irbesartan can ameliorate hyperlipidemia and liver steatosis by upregulating Akt (show AKT1 Antibodies) signaling pathway and inducing liver autophagy

  9. BDNF (show BDNF Antibodies)-overexpression may not only facilitate the recovery of locomotor function via AKT (show AKT1 Antibodies) pathway, but also contributed simultaneously to thermal hyperalgesia after spinal cord injury

  10. Data suggest that expression, processing, and activation of (that is, signal transduction via) Notch1 (neurogenic locus notch homolog protein 1 (show NOTCH1 Antibodies)), Pten (phosphatase and tensin homolog (show PTEN Antibodies)), and Akt1 (thymoma viral proto-oncogene 1) are involved in oogenesis; oogenesis proceeds via both recruitment of primordial follicles and proliferation of granulosa cells.

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Antibodies) and IL8 (show IL8 Antibodies) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  2. Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Antibodies) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  3. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.

  4. Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Antibodies).

  5. Src (show SRC Antibodies) has a role in priming Pyk2 (but not FAK (show PTK2 Antibodies)) phosphorylation and subsequent activation downstream of integrins

  6. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  7. FAK (show PTK2 Antibodies) and PYK2 functioned redundantly to promote the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway by phosphorylating GSK3beta (show GSK3b Antibodies)(Y216) to reinforce pathway output-beta-catenin (show CTNNB1 Antibodies) accumulation and intestinal tumorigenesis.

  8. This study identified Pyk2 as a cellular component required for the intracellular trafficking of HPV16 during infection.

  9. These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK (show PTK2 Antibodies)/Pyk2 signaling pathways.

  10. data suggest a novel role for FAK (show PTK2 Antibodies) in GPVI (show GP6 Antibodies)-dependent ROS (show ROS1 Antibodies) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Antibodies) within the GPVI (show GP6 Antibodies) pathway.

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) antibody
  • thymoma viral proto-oncogene 1 (Akt1) antibody
  • protein tyrosine kinase 2 beta (PTK2B) antibody
  • protein tyrosine kinase 2 beta (Ptk2b) antibody
  • PTK2 protein tyrosine kinase 2 beta (Ptk2b) antibody
  • PTK2B protein tyrosine kinase 2 beta (PTK2B) antibody
  • Akt antibody
  • CADTK antibody
  • CAKB antibody
  • CAKbeta antibody
  • E430023O05Rik antibody
  • FADK2 antibody
  • FAK2 antibody
  • PKB antibody
  • PKB/Akt antibody
  • PKBalpha antibody
  • PTK antibody
  • Pyk2 antibody
  • Rac antibody
  • Raftk antibody

Protein level used designations for PTK2B

AKT1 kinase , PKB alpha , RAC protein kinase alpha RAC-PK alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , murine thymoma viral (v-akt) oncogene homolog 1 , protein kinase B alpha , thymoma viral proto-oncogene 1 , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , cellular adhesion kinase beta , protein tyrosine kinase 2 beta

GENE ID SPECIES
24185 Rattus norvegicus
11651 Mus musculus
2185 Homo sapiens
50646 Rattus norvegicus
19229 Mus musculus
486102 Canis lupus familiaris
541008 Bos taurus
421998 Gallus gallus
100157507 Sus scrofa
100342358 Oryctolagus cuniculus
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