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Browse our anti-PTK2B (PTK2B) Antibodies

Full name:
anti-PTK2B Protein tyrosine Kinase 2 beta Antibodies (PTK2B)
On www.antibodies-online.com are 243 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antibodies from 25 different suppliers available. Additionally we are shipping PTK2B Kits (20) and PTK2B Proteins (11) and many more products for this protein. A total of 292 PTK2B products are currently listed.
Synonyms:
Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, Pyk2, Rac, Raftk
list all antibodies Gene Name GeneID UniProt
PTK2B 24185 P47196
PTK2B 11651 P31750
PTK2B 2185 Q14289

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Top referenced anti-PTK2B Antibodies

  1. Human Polyclonal PTK2B Primary Antibody for IF, IHC (p) - ABIN196952 : Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004 (PubMed)
    Show all 5 references for ABIN196952

  2. Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705 : Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004 (PubMed)
    Show all 3 references for ABIN1724705

  3. Human Polyclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1532112 : Lev, Moreno, Martinez, Canoll, Peles, Musacchio, Plowman, Rudy, Schlessinger: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. in Nature 1995 (PubMed)
    Show all 2 references for ABIN1532112

  4. Human Polyclonal PTK2B Primary Antibody for ELISA, WB - ABIN1533144 : Herzog, Nicholl, Hort, Sutherland, Shine: Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization. in Genomics 1997 (PubMed)
    Show all 2 references for ABIN1533144

  5. Human Polyclonal PTK2B Primary Antibody for IF, IHC (p) - ABIN197440 : Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 references for ABIN197440

  6. Human Polyclonal PTK2B Primary Antibody for IF (p), IHC (p) - ABIN745763 : Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015 (PubMed)

  7. Cow (Bovine) Polyclonal PTK2B Primary Antibody for WB - ABIN2779800 : Ling, Sheng, Braun: The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation. in American journal of physiology. Cell physiology 2004 (PubMed)

More Antibodies against PTK2B Interaction Partners

Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt (show AKT1 Antibodies) phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atroph

  2. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (show AKT1 Antibodies) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  3. Data show that Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways were activated in ovine pulmonary adenocarcinoma (OPA) lung and envelope (Env (show ERVW-1 Antibodies)) of Jaagsiekte sheep retrovirus (JSRV) transfected NIH 3T3 cells.

  4. Results suggest that SC79 compound activates Akt (show AKT1 Antibodies)-Nrf2 (show NFE2L2 Antibodies) signaling to protect osteoblasts from dexamethasone (Dex).

  5. In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1 (show PDPK1 Antibodies)/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1 (show PDPK1 Antibodies). This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati

  6. Taken together, our findings imply that KLF15 possesses potential anti-hypertrophic and anti-fibrotic functions, possibly via regulation of cell death pathways and the inhibition of Akt/mTOR axis. KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases.

  7. Menin (show MEN1 Antibodies) binds on the promoter of Inhbb (show INHBB Antibodies) gene where it favours the recruitment of Ezh2 (show EZH2 Antibodies) via an indirect mechanism involving Akt (show AKT1 Antibodies)-phosphorylation.

  8. A role of AKT (show AKT1 Antibodies) in the regulatory T cell differentiation process. TGF-beta (show TGFB1 Antibodies) induces the phosphorylation of Akt (show AKT1 Antibodies) in CD4 (show CD4 Antibodies)+ T cells.

  9. 4-PBA reverses autophagic dysfunction and improves insulin (show INS Antibodies) sensitivity in adipose tissue of obese mice via Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling partly, which could be regarded as novel opportunities for treatment of insulin (show INS Antibodies) resistance.

  10. These studies reveal a novel mechanism in which CYP2J2 (show CYP2J2 Antibodies) and epoxyeicosatrienoic acids enhanced Akt1 (show AKT1 Antibodies) nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy.

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (show PIK3CA Antibodies)-Akt/PKB (show AKT1 Antibodies) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  2. PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.

  3. Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Antibodies) and IL8 (show IL8 Antibodies) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  4. Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Antibodies) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  5. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.

  6. Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Antibodies).

  7. Src (show SRC Antibodies) has a role in priming Pyk2 (but not FAK (show PTK2 Antibodies)) phosphorylation and subsequent activation downstream of integrins

  8. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  9. FAK (show PTK2 Antibodies) and PYK2 functioned redundantly to promote the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway by phosphorylating GSK3beta (show GSK3b Antibodies)(Y216) to reinforce pathway output-beta-catenin (show CTNNB1 Antibodies) accumulation and intestinal tumorigenesis.

  10. This study identified Pyk2 as a cellular component required for the intracellular trafficking of HPV16 during infection.

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) antibody
  • thymoma viral proto-oncogene 1 (Akt1) antibody
  • protein tyrosine kinase 2 beta (PTK2B) antibody
  • protein tyrosine kinase 2 beta (Ptk2b) antibody
  • PTK2 protein tyrosine kinase 2 beta (Ptk2b) antibody
  • PTK2B protein tyrosine kinase 2 beta (PTK2B) antibody
  • Akt antibody
  • CADTK antibody
  • CAKB antibody
  • CAKbeta antibody
  • E430023O05Rik antibody
  • FADK2 antibody
  • FAK2 antibody
  • PKB antibody
  • PKB/Akt antibody
  • PKBalpha antibody
  • PTK antibody
  • Pyk2 antibody
  • Rac antibody
  • Raftk antibody

Protein level used designations for PTK2B

AKT1 kinase , PKB alpha , RAC protein kinase alpha RAC-PK alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , murine thymoma viral (v-akt) oncogene homolog 1 , protein kinase B alpha , thymoma viral proto-oncogene 1 , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , cellular adhesion kinase beta , protein tyrosine kinase 2 beta

GENE ID SPECIES
24185 Rattus norvegicus
11651 Mus musculus
2185 Homo sapiens
50646 Rattus norvegicus
19229 Mus musculus
486102 Canis lupus familiaris
541008 Bos taurus
421998 Gallus gallus
100157507 Sus scrofa
100342358 Oryctolagus cuniculus
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