PTK2B antibody (pTyr579)

Catalog No. ABIN7139029

The Rabbit Polyclonal anti-PTK2B antibody (ABIN7139029) specifically detects PTK2B in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for PTK2B antibody (pTyr579) (ABIN7139029)

Target: PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTK2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PTK2B Antibody

Binding Specificity: pTyr579

Purpose: Phospho-PTK2B (Tyr579) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 579(E-D-Y(p)-Y-K) derived from Human PYK2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTK2B

Target: PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

Alternative Name: PTK2B

Background:

Background:

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Lev S., Nature 376:737-745(1995).
Herzog H., Genomics 32:484-486(1996).
Sasaki H., J. Biol. Chem. 270:21206-21219(1995).

Aliases: CADTK antibody, CAK-beta antibody, CAKB antibody, CAKbeta antibody, Calcium regulated non receptor proline rich tyrosine kinase antibody, Calcium-dependent tyrosine kinase antibody, Cell adhesion kinase beta antibody, E430023O05Rik antibody, EC 2.7.10.2 antibody, FADK 2 antibody, FADK2 antibody, FAK2 antibody, FAK2_HUMAN antibody, Focal adhesion kinase 2 antibody, MGC124628 antibody, PKB antibody, Proline-rich tyrosine kinase 2 antibody, Protein kinase B antibody, Protein Tyrosine Kinase 2 Beta antibody, Protein-tyrosine kinase 2-beta antibody, PTK antibody, PTK2B antibody, PTK2B protein tyrosine kinase 2 beta antibody, PYK2 antibody, RAFTK antibody, RAFTK2 antibody, Related adhesion focal tyrosine kinase antibody

UniProt: Q14289

Pathways: EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling