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CTHRC1 was established as a novel marker of activated synoviocytes in murine experimental arthritis and rheumatoid arthritis
ANOS1 and its co-expression partner, CTHRC1, promote the development and metastasis of colorectal cancer.
Expression of CTHRC1 was significantly higher in Wilms' tumor compared to the expression in the adjacent non-cancerous tissues. High tumor expression of CTHRC1 was associated with tumor size, clinical stage, histopathological type, and vascular invasion/metastasis. Patients with high CTHRC1 expression also exhibited a shorter survival.
CTHRC1 expression is significantly upregulated in human masticatory mucosa during wound healing.
CTHRC1 downregulation inhibited proliferation.
The knockdown of CTHRC1 exerts inhibitory effects on the proliferation and migration ability of glioblastoma cells.
CTHRC1 may play a role in the progression of ovarian cancer.
this study shows that the serum CTHRC1 level was significantly higher in the influenza A virus infection patients than in the healthy individuals; the influenza A virus non-structural protein NS1 (show PTPN11 Proteins) upregulates the expression of CTHRC1 protein
Gene expression levels of three randomly selected DEGs (show DEGS1 Proteins), VCAN (show Vcan Proteins), COL5A1 and KCNJ16 (show KCNJ16 Proteins), were examined using RT-PCR in 10 ATC (show SRPK1 Proteins) samples.. angiogenesis was activated by the high expression of CTHRC1, VCAN (show Vcan Proteins) and POSTN (show POSTN Proteins), providing necessary nutrition for tumor cells
increased CTHRC1 expression is associated with advanced TNM (show ODZ1 Proteins) stage, increased LN metastasis and tumor size, and decreased OS and DFS (show FST Proteins), indicating that CTHRC1 may be a biomarker for prognosis of cancer patients
CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling.
This study demonstrated that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.
this is the first demonstration of Cthrc1 as a marker of the severity of the disease progression in the dystrophic muscles.
Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen (show GYS1 Proteins) levels with potentially broad implications for cell metabolism and physiology.
Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb (show PDGFRB Proteins) promoter driven Cre dependent myc (show MYC Proteins)-tagged Cthrc1 transgene expression.
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1 (show BCMO1 Proteins)-deficient mice.
Cthrc1 expression overlaps considerably with those reported for TGF-beta (show TGFB1 Proteins) family members and interstitial collagens.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
collagen triple helix repeat containing 1
, collagen triple helix repeat-containing protein 1