CTHRC1 Protein (AA 31-243) (His tag)

Catalog No. ABIN1880698

Recombinant CTHRC1 protein expressed in Human Cells.

Quick Overview for CTHRC1 Protein (AA 31-243) (His tag) (ABIN1880698)

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 31-243

Purification tag / Conjugate: This CTHRC1 protein is labelled with His tag.

Purpose: Recombinant Human CTHRC1/NMTC1 (C-6His)

Sequence: SEIPKGKQKA QLRQREVVDL YNGMCLQGPA GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE LPKVDHHHHH H

Characteristics: Recombinant Human Collagen triple helix repeat-containing protein 1/CTHRC1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser31-Lys243) of Human CTHRC1 fused with a polyhistidine tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Alternative Name: CTHRC1

Background: Collagen triple helix repeat-containing protein 1 is a protein that in humans is encoded by the CTHRC1 gene. It acts as a negative regulator of collagen matrix deposition. It may cause the disease of Barrett esophagus . Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

Molecular Weight: 24.1 kDa

UniProt: Q96CG8

Pathways: Tube Formation