anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Antibodies

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS5 Kits (26) and ADAMTS5 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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Top anti-ADAMTS5 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using ADAMTS5, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: JC 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048292 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048295 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Hamster Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048293 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048294 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048296 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ADAMTS5 Antibody (Center) in mouse muscle tissue lysates (35ug/lane). ADAMTS5(arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Human Placenta (formalin-fixed, paraffin-embedded) stained with ADAMTS5 antibody ABIN625839 at 14 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 11 to 14 Days
$419.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit Anti Aggrecanase-2/ADAMTS5 Polyclonal Antibody, Unconjugated (ABIN701005) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Aggrecanase-2/ADAMTS5 Polyclonal Antibody, Unconjugated (ABIN701005) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details

Top referenced anti-ADAMTS5 Antibodies

  1. Human Polyclonal ADAMTS5 Primary Antibody for IHC, IHC (p) - ABIN4278306 : Ding, Zampogna, Vasta, Jang, De Caro, Martin, Amendola: Why Do Osteochondral Allografts Survive? Comparative Analysis of Cartilage Biochemical Properties Unveils a Molecular Basis for Durability. in The American journal of sports medicine 2016 (PubMed)

  2. Human Polyclonal ADAMTS5 Primary Antibody for IHC, WB - ABIN3016806 : Si, Zeng, Liu, Zhou, Chen, Cheng, Lu, Shen: Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. in Osteoarthritis and cartilage 2018 (PubMed)

More Antibodies against ADAMTS5 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. In the absence of ADAMTS5, cleavage of versican in the cardiac extracellular matrix is impaired, but cardiac function, even upon exposure to a HFD, is not markedly affected.

  2. ADAMTS5 is the primary aggrecanase mediating smoking-induced intervertebral disc degeneration.

  3. Upper zone of growth plate and cartilage matrix associated protein (Ucma) physically interacted with a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) protein (ADAMTS5) and blocked its aggrecanase activity in chondrocyte cultures.

  4. ADAMTS5 plays a functional role in development of brown adipose tissue and browning of white adipose tissue.

  5. Energy expenditure and thermogenesis were not significantly different between KO and WT ADAMTS5-J mice (in contrast to somewhat enhanced levels in ADAMTS5-P mice). Insulin sensitivity was improved in the ADAMTS5-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model

  6. Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.

  7. research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality

  8. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan and Vcan by an ADAMTS other than TS5.

  9. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  10. aggrecan and brevican proteolysis is compensated in Adamts4-/- or Adamts5-/- mice by ADAMTS proteoglycanase family members but a threshold of versican proteolysis is sensitive to the loss of a single ADAMTS proteoglycanase during spinal cord injury

  11. The present study reveals ADAMT-5 expression by mast cells(MCs) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  12. Western blot analyses indicated that aggrecanase-generated proteoglycan fragments are produced after SCI.

  13. RelA/p65 is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  14. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

  15. this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.

  16. The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes.

  17. Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation.

  18. the first evidence implicating ADAMTS-5 in the regulation of proteoglycan turnover and lipoprotein retention in atherosclerosis.

  19. The role of ADAMTS5 in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.

  20. Adamts5 induction in joint components other than cartilage, and its post-translational activation by PACE4 and/or furin may be important in the pathophysiology of arthritis.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. significantly higher second-trimester amniotic fluid levels in pregnant women with spontaneous preterm birth

  2. ADAMTS-5 is the key protease for versican regulation in murine aortas undergoing dilatation and extracellular matrix remodeling in model of thoracic aortic aneurysms.

  3. Since only two of the collected studies referred to ADAMTS4, we did not perform meta-analysis for these comparisons. Taken together, rs226794 and rs2830585 in ADAMTS5 gene were not associated with musculoskeletal degenerative diseases in overall population, but there seemed to be an ethnicity-dependent effect of rs2830585 in the risk of musculoskeletal degenerative diseases

  4. ADAMTS5 is downregulated in gastric cancer and suppresses tumor metastasis and angiogenesis

  5. High ADAMTS5 expression is associated with osteoarthritic cartilage deterioration.

  6. ADAMTS5 was uniquely downregulated in Barlow's Disease.

  7. expressed 2.1-fold less in Sertoli cells in nonobstructive azoospermia than in obstructive azoospermia; insufficient expression in Sertoli cells may have an important role in the etiology of male infertility

  8. the ADAMTS5 rs2830585 polymorphism may be involved in the development of knee osteoarthritis by destroying the extracellular matrix, but this finding should be further confirmed by larger studies.

  9. Data suggest that 3prime untranslated region of ADAMTS5 mRNA contains 'seedmatched-sequence' for hsa-miR-140-3p (microRNA-140-3p); in chondrocytes from articular cartilage of patients with knee osteoarthritis, interleukin-1beta up-regulates expression of ADAMTS5 and down-regulates expression of hsa-miR-140-3p. (ADAMTS5 = ADAM metallopeptidase with thrombospondin type 1 motif 5 A)

  10. A novel genetic variant in ADAMTS5 is associated with bicuspid aortic valve disease.

  11. expression by synovial cells induced by hemoglobin at low doses, suggesting a possible role for hemoglobin in cartilage damage after intra-articular hemorrhage

  12. The SNPs rs1337185 in COL11A1 and rs162509 in ADAMTS5 are associated with susceptibility to lumbar disc degeneration. The C allele of rs1337185 is risky for patients who are affected by lumbar pathologies such as disc herniation, stenosis and spondylolisthesis. The G allele of rs16250 represents a risk factor for the development of disc herniation.

  13. ADAMTS5 is hypermethylated and inhibits cancer cells invasion and migration in colorectal cancer, and correlates with OS and DFS.

  14. Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

  15. MMP-13 may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 and its internalization is independent of the levels of ADAMTS-4, -5 and TIMP-3.

  16. The IL1B/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in osteoarthritis.

  17. The findings suggest that miR-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5.

  18. Results provide direct evidence indicating that Fibulin-2 is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 and the ADAMTSs metalloproteases.

  19. Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13, and decreased COL2A1 expression.

  20. Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.

  2. ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 Antigen Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene names and symbols associated with ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (adamts5) antibody
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) antibody
  • 9530092O11Rik antibody
  • ADAM-TS5 antibody
  • ADAM-TS 5 antibody
  • ADAM-TS 11 antibody
  • ADAMTS-5 antibody
  • ADAMTS-11 antibody
  • ADAMTS1 antibody
  • ADAMTS11 antibody
  • ADMP-2 antibody
  • AI481094 antibody
  • ASMP-2 antibody

Protein level used designations for ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPECIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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