ADAMTS5 antibody (C-Term)

Catalog No. ABIN2854716

Product Details anti-ADAMTS5 Antibody

Target: ADAMTS5 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to ADAMTS5 (A disintegrin and metalloproteinase with thrombospondin motifs 5)
ADAMTS5 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ADAMTS5. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HCT116, MCF-7 , JC

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-ADAMTS5 antibody (ABIN2854716)

Wang, Ye, Ye, Wang, Liu, Jiang, Xu, Zhang, Chen, Wan: "ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease." in: Disease markers, Vol. 2019, pp. 6129748, (2020) (PubMed).

Target Details for ADAMTS5

Target: ADAMTS5 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))

Alternative Name: ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5 Products)

Synonyms: 9530092O11Rik antibody, ADAM-TS5 antibody, ADAMTS1 antibody, ADAMTS11 antibody, AI481094 antibody, ASMP-2 antibody, ADAM-TS 11 antibody, ADAM-TS 5 antibody, ADAMTS-11 antibody, ADAMTS-5 antibody, ADMP-2 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 5 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 5 antibody, ADAMTS5 antibody, adamts5 antibody, Adamts5 antibody

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Molecular Weight: 102 kDa

Gene ID: 11096

UniProt: Q9UNA0