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The enzyme encoded by ADPRH catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Additionally we are shipping ADPRH Kits (19) and ADPRH Proteins (11) and many more products for this protein.
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Silencing of the putative maternally imprinted tumor suppressor gene ARHI serves as a key early event in follicular thyroid carcinogenesis.
prerequisite for obtaining well diffracting crystals was the performance of X-ray fluorescence analysis on poorly diffracting apo hARH1 crystals, which revealed the presence of trace amounts of K(+) in the crystal
Intestinal loops derived from female ADP-ribosylarginine hydrolase knockout (ARH1-KO) mice when injected with cholera toxin showed increased fluid accumulation compared to male ARH1-KO mice.
ARH1(-/-) and ARH1(+/-) mice spontaneously develop lymphomas, adenocarcinomas, & metastases more frequently than wild-type. Proper control of protein ADP-ribosylation levels affected by ARH1 is essential for cancer suppression.
ADP-ribosylarginine hydrolase promoter activity pattern and involvement of Sp transcription factors are consistent with prior observations of widespread hydrolase expression in mammalian tissues.
Cholera toxin-catalyzed ADP-ribosylation of cell proteins can be counteracted by ADPRH, which could function as a modifier gene in disease.
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes, which require DTT for maximal activity, the human enzyme is DTT-independent.
ADP-ribose-L-arginine cleaving enzyme
, [Protein ADP-ribosylarginine] hydrolase
, ADP-ribosylarginine hydrolase
, protein ADP-ribosylarginine hydrolase-like
, uncharacterized protein LOC495095