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AFF3 encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Additionally we are shipping and many more products for this protein.
Showing 10 out of 16 products:
Dog (Canine) Polyclonal AFF3 Primary Antibody for WB - ABIN2778345
To, Faseruk, Gokgoz, Pinnaduwage, Done, Andrulis: LAF-4 is aberrantly expressed in human breast cancer. in International journal of cancer. Journal international du cancer 2005
Data identified AFF3 as an interactive protein with beclin1 (show BECN1 Antibodies) and suggest that AFF3 is probably a key regulator of Beclin-1 (show BECN1 Antibodies).
Both the AFF3 and NTM (show NTM Antibodies) triglyceride associations were replicated among Multi-ethnic Study of Atherosclerosis study participants (P = 1.00 x 10(-7) and 8.00 x 10(-5), respectively).
FRA2A-expressing individuals have mosaic expansions of the AFF3 CGG repeat.
Significant evidence for association of AFF3 rs10865035 with systgemic lupus erythmatgosus was detected.
overexpression of AFF2 (show AFF2 Antibodies)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.
The LAF4 gene mapped on chromosome region 2q11.2-q12 has been identified as a fusion partner of the MLL (show MLL Antibodies) gene in a case of infant acute lymphoblastic leukemia.
This gene is fused to MLL (show MLL Antibodies) in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23).
LAF-4 may be a proto-oncogene (show RAB1A Antibodies) that is transcriptionally activated in some cases of breast cancer.
array comparative genomic hybridization (CGH) analysis revealed a de novo interstitial microdeletion of 500 kb on chromosome 2q11.1 containing the LAF4/AFF3 (lymphoid-nuclear-protein (show RDBP Antibodies)-related AF4) gene
A novel fusion 5'AFF3/3'BCL2 (show BCL2 Antibodies) originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma.
AFF3 is associated with the Kruppel-like zinc finger protein ZFP281 in embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron.
The neuronal migration deficit caused by loss of Laf4 can be partially rescued by Mdga2 (show MDGA2 Antibodies) over-expression, revealing an important functional relationship between these genes in a mouse model of intellectual disability.
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
AF4/FMR2 family, member 3
, AF4/FMR2 family member 3
, MLLT2-related protein
, lymphoid nuclear protein 4
, lymphoid nuclear protein related to AF4
, protein LAF-4