Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins (5) and many more products for this protein.
Showing 10 out of 39 products:
Human Polyclonal ABCB1B Primary Antibody for FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
Show all 2 Pubmed References
13-cis (show CISH Antibodies)-retinoic acid, retinol and retinyl-acetate inhibited the Pgp (show PGPEP1 Antibodies) and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase (show DNAH8 Antibodies) activity of these transporters.
Haplotype analysis of ABCB1 (show ABCB1 Antibodies) conducted in patients with bullous pemphigoid (show DST Antibodies) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.
High ABCB1 (show ABCB1 Antibodies) expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.
Data show that multidrug resistance gene 1 (MDR1 (show TBC1D9 Antibodies)) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.
ABCB1 (show ABCB1 Antibodies) variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin
Our data showed that the expression of the MDR1 (show TBC1D9 Antibodies) gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (show STS Antibodies). In addition, high MDR1 (show TBC1D9 Antibodies) expression was significantly associated with local advances, as well as poor response to treatment.
These results indicated that MG132 reversed the MDR of hypopharyngeal carcinoma by downregulating Pgp/Pgp, and the underlying mechanism may be associated with the activation the of the JNK signaling pathway
This study elaborated a novel UCA1/miR (show MLXIP Antibodies)-129/ABCB1 (show ABCB1 Antibodies) regulatory axis underlying paclitaxel resistance of ovarian cancer cells.
ABCB1 (show ABCB1 Antibodies) 3435C>T and ATIC (show ATIC Antibodies) 347C>G SNPs were associated with abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis.
The role of multidrug resistance 1 gene (MDR1 (show TBC1D9 Antibodies) or ABCB1 (show ABCB1 Antibodies)) polymorphism G2677T was studied in relation to paroxetine therapeutic efficacy and its side effects, as well as its association with selected demographic and clinical characteristics of patients with depressive disorder.
this study shows that MDR1 (show ABCB4 Antibodies) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (show ABCB4 Antibodies) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (show ABCB4 Antibodies)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (show ABCB4 Antibodies) can affect the pulmonary kinetics of a subset of P-gp (show ABCB4 Antibodies) substrates.
Data suggest that the overexpression of P-gp (show ABCB4 Antibodies) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 Antibodies), multi-drug resistance protein, MDR1 (show ABCB4 Antibodies)).Drugs with ER < 1 (show MIER1 Antibodies) almost do not bind the main binding cavity (MBC (show CACNA1C Antibodies)) of P-gp (show ABCB4 Antibodies).
conclusion, MDR1 (show ABCB4 Antibodies) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A Antibodies)-II layer.
Mdr1 (show ABCB4 Antibodies) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (show ABCB1 Antibodies) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (show ABCB4 Antibodies) ATPase (show DNAH8 Antibodies) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1