Aconitase 2, Mitochondrial Proteins (ACO2)

The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. Additionally we are shipping ACO2 Antibodies (138) and ACO2 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACO2 50 Q99798
ACO2 11429 Q99KI0
ACO2 79250 Q9ER34
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Top ACO2 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Baculovirus infected Insect Cells Human GST tag,His tag 10 μg 14 to 16 Days
$311.24
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Baculovirus infected Insect Cells Mouse GST tag,His tag 100 μg 14 to 16 Days
$505.35
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$4,203.83
Details

ACO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Aconitase 2, Mitochondrial (ACO2) Interaction Partners

Arabidopsis thaliana Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.

Human Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Mutation in ACO2 gene is associated with optic neuropathy.

  2. Aco2 activity correlated significantly with motor score, independence scale, and functional capacity of the Unified Huntington's Disease Rating Scale as well as disease duration. Our study provides a potential biomarker to assess the disease status of HD patients and PreHD carriers.

  3. Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection

  4. Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.

  5. immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men

  6. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  7. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells

  8. Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.

  9. Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.

  10. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.

  11. abolishes oxidant-induced apoptosis

  12. Lon protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase after mild oxidative modification, but that severe oxidation results in aconitase aggregation, which makes it a poor substrate for Lon.

  13. ACO2 is often deleted in colorectal cancer but is unlikely to be the true target of the deletions

  14. The m-aconitase promoter is contained in a 153-bp 5' fragment lacking a TATA or CAAT sequence. Sp1 binding to specific Sp1 site is needed for promoter activity. Other transcription factors are recruited through protein-protein interactions.

  15. Manganese acts as an antagonist of iron, disrupting the enzymatic activity and gene expression of mACON and citrate metabolism in the prostate.

  16. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.

  17. This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Mouse (Murine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Activation of mitochondrial aconitase is acetylation-dependent.

  2. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  3. IRP-1,-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development

  4. aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation

Pig (Porcine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria

ACO2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Gene names and symbols associated with ACO2

  • aconitase 2 (ACO2)
  • aconitase 2 S homeolog (aco2.S)
  • aconitate hydratase, mitochondrial (Bm1_07420)
  • aconitase, mitochondrial (aco2)
  • mitochondrial aconitate hydratase (ach1)
  • aconitase 2 (aco2)
  • aconitase 2, mitochondrial (Aco2)
  • aconitase 2 (Aco2)
  • aconitase 2, mitochondrial (aco2)
  • Probable aconitate hydratase, mitochondrial (aco-2)
  • Aco-2 protein
  • Aco3 protein
  • aconitase 2 protein
  • ACONM protein
  • cb1017 protein
  • D10Wsu183e protein
  • DDBDRAFT_0206187 protein
  • DDBDRAFT_0230168 protein
  • DDB_0206187 protein
  • DDB_0230168 protein
  • F10M23.310 protein
  • F10M23_310 protein
  • ICRD protein
  • wu:fa10e03 protein
  • wu:fb69g04 protein
  • wu:fc20c11 protein

Protein level used designations for ACO2

aconitate hydratase, mitochondrial , mitochondrial aconitate hydratase , aconitase 2, mitochondrial , aconitate hydratase, mitochondrial-like , citrate hydro-lyase , mitochondrial aconitase (nuclear aco2 gene) , heart aconitase

GENE ID SPECIES
374009 Gallus gallus
444692 Xenopus laevis
6096411 Brugia malayi
8621690 Dictyostelium discoideum AX4
9617127 Volvox carteri f. nagariensis
100444223 Pongo abelii
496933 Xenopus (Silurana) tropicalis
707441 Macaca mulatta
828805 Arabidopsis thaliana
100352714 Oryctolagus cuniculus
100389367 Callithrix jacchus
100568244 Anolis carolinensis
100598337 Nomascus leucogenys
50 Homo sapiens
11429 Mus musculus
79250 Rattus norvegicus
396999 Sus scrofa
280976 Bos taurus
474487 Canis lupus familiaris
322670 Danio rerio
176121 Caenorhabditis elegans
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