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ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. Additionally we are shipping and many more products for this protein.
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Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP/PDGFRB (show PDGFRB Antibodies) fusion. In this case, a variant fusion was created between ATF7IP exon 9 (instead of exon 13) and PDGFRB (show PDGFRB Antibodies) exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP/PDGFRB (show PDGFRB Antibodies) fusion cDNA and its encoded chimeric protein, respectively.
these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 (show SETDB1 Antibodies) abundance in the nucleus.
results indicate that ATF7IP does not directly modulate SETDB1 (show SETDB1 Antibodies) catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.
these results indicate a critical role for MCAF1 in AP-1 (show FOSB Antibodies)-dependent Rta (show RBM9 Antibodies) activation of BZLF1 transcription.
We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 (show DPEP1 Antibodies) protein complex in maintaining central tolerance
The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.
Genetic variants at ATF7IP and KLK2 (show KLK2 Antibodies) contribute to the variance of %fPSA.
Studies identified three new susceptibility loci DMRT1 (show DMRT1 Antibodies), TERT (show TERT Antibodies) and ATF7IP associated with testicular germ cell cancer.
mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1 (show SETDB1 Antibodies)
These data suggest that MBD1 (show DPEP1 Antibodies).MCAF1.SETDB1 (show SETDB1 Antibodies) complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF (show CCL2 Antibodies)/AM family proteins in epigenetic control, and describe a new family member, MCAF2 (show ATF7IP2 Antibodies).
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009
activating transcription factor 7-interacting protein 1
, activating transcription factor 7 interacting protein
, activating transcription factor 7-interacting protein 1-like
, ATF-interacting protein
, ATF7-interacting protein
, ATFa-associated modulator
, MBD1-containing chromatin associated factor
, MBD1-containing chromatin-associated factor 1
, ATFa-associated Modulator