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ACVR2A encodes activin A type II receptor. Additionally we are shipping Activin Receptor Type IIA Antibodies (123) and Activin Receptor Type IIA Kits (17) and many more products for this protein.
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Altered decidual ACVR2A expression impairs the ability of stromal cells to properly decidualise and regulate trophoblast function at the maternalfetal interface, which may result in abnormal placentation that can lead to poor pregnancy outcomes such as pre-eclampsia.
Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 (show AGTR1 Proteins) and RGS2 (show RGS2 Proteins) in women with preeclampsia
TGF-beta (show TGFB1 Proteins) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 (show ZEB2 Proteins) and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.
Data suggest ALK1 (show ACVRL1 Proteins) and ACVR2A/ACVR2B (show ACVR2B Proteins), acting as BMP9 (show GDF2 Proteins) co-receptors, rearrange pro-domains of BMP9 (show GDF2 Proteins)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
Activin A (show INHBA Proteins) inhibited signaling by BMP-6 (show BMP6 Proteins) and BMP-9 (show GDF2 Proteins) by competing for type 2 receptors ACVR2A and ACVR2B (show ACVR2B Proteins).
Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (show INHBA Proteins) (as seen in pre-eclampsia).
Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.
The gene ACVR2A was associated with the more severe early onset preeclampsia.
For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
miRNA-424/503 cluster members target the SMAD7 and ACVR2A genes which are involved in the activin signalling pathway
This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.
Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s.
Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.
Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B (show ACVR2B Proteins) or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B (show ACVR2B Proteins)-deficient mice exhibit no significant change in any bone parameter.
miR (show MLXIP Proteins)-125b regulated the activin/Smad2 (show SMAD2 Proteins) signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a
Our study shows that a miR (show MLXIP Proteins)-590/Acvr2a/Rad51b (show Rad51B Proteins) signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
Bmpr2 (show BMPR2 Proteins) and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1 (show HAND1 Proteins), Th2, and Treg.
stimulates expression of APRIL via the Smad3 (show SMAD3 Proteins) and ERK (show EPHB2 Proteins)/CREB (show CREB1 Proteins) pathways in macrophages
Results demonstrated that BMPRII (show BMPR2 Proteins) and ActRII are the functional type II TGF-beta (show TGFB1 Proteins) receptors in BMP-9 (show GDF2 Proteins)-induced osteogenic differentiation of C3H10T1/2 cells.
The coordinated activity of ActRIIA and BMPRII (show BMPR2 Proteins) receptor subunits selectively mediates the chemotactic response to BMP7 (show BMP7 Proteins).
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
activin receptor IIA
, activin receptor type-2A
, activin A receptor, type IIA
, activin receptor type IIA
, type II activin receptor
, activin A receptor, type II
, activin receptor, type IIA
, activin receptor type II
, activin type 2 receptor
, activin receptor IIa