Activin A Receptor, Type IIA Proteins (ACVR2A)

ACVR2A encodes activin A type II receptor. Additionally we are shipping Activin Receptor Type IIA Antibodies (127) and Activin Receptor Type IIA Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACVR2A 92 P27037
ACVR2A 29263 P38444
ACVR2A 11480 P27038
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Top Activin Receptor Type IIA Proteins at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Mouse His tag 100 μg Log in to see 14 to 16 Days
$285.35
Details
Human Cells Human Fc Tag 100 μg Log in to see 14 to 16 Days
$285.35
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Human Cells Human Fc Tag,His tag   50 μg Log in to see 4 Days
$203.50
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$701.00
Details
Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 13 to 16 Days
$400.00
Details
HEK-293 Cells Human Fc Tag Human Activin RIIA, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human Activin A, Tag Free  with a linear range of 0.08-0.625 μg/mL. 200 μg Log in to see 2 to 3 Days
$319.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$340.00
Details

ACVR2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , , ,
Rat (Rattus)

Mouse (Murine) , ,
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More Proteins for Activin A Receptor, Type IIA (ACVR2A) Interaction Partners

Human Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. The multifactor dimensionality reduction algorithm identified an interaction between age, body mass index and ACVR2A rs1014064, indicating that context among genetic variants and demographic/clinical factors may be crucial to understanding the pathogenesis of preeclampsia among Filipino women.

  2. Altered decidual ACVR2A expression impairs the ability of stromal cells to properly decidualise and regulate trophoblast function at the maternalfetal interface, which may result in abnormal placentation that can lead to poor pregnancy outcomes such as pre-eclampsia.

  3. Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2 in women with preeclampsia

  4. TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(

  5. This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.

  6. Data suggest ALK1 and ACVR2A/ACVR2B, acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.

  7. Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B.

  8. Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (as seen in pre-eclampsia).

  9. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.

  10. The gene ACVR2A was associated with the more severe early onset preeclampsia.

  11. For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.

  12. ACVR2A was identified as a subnetwork component in functional association network analysis.

  13. ACVR2A showed statistically significant differential dose-expression relationship.

  14. ACVR2A interaction with Nodal and ADMP regulates head development from the 'organizer', a restricted group of cells in the embryo.

  15. This is the first report on the function of miR-195 in human placental trophoblast cells which reveals an invasion-promoting effect of the small RNA via repressing ActRIIA.

  16. Activin type IIA receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain.

  17. Exonic selectivity for frameshift mutation within ACVR2 is specifically controlled by individual nucleotides flanking each coding ACVR2 microsatellite.

  18. Mutation in activin type II receptor is associated with colorectal cancer.

  19. Of 51 microsatellite stable colon tumors, 7 (14%) lost ACVR2, 2 (4%) ACVR1, and 5 (10%) pSMAD2 expression.

  20. distribution in gestational tissues across human pregnancy and during labour

Cow (Bovine) Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. miRNA-424/503 cluster members target the SMAD7 and ACVR2A genes which are involved in the activin signalling pathway

  2. This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.

Zebrafish Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. Inhbaa signaled through Acvr2a over Acvr2b during zebrafish cardiac regeneration.

  2. Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.

Mouse (Murine) Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. Activation of ActRIIA signaling during early chronic kidney disease contributes to the CKD-MBD components of osteodystrophy and cardiovascular disease and to renal fibrosis.

  2. blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s.

  3. Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.

  4. Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter.

  5. miR-125b regulated the activin/Smad2 signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a

  6. Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.

  7. Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.

  8. Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg.

  9. stimulates expression of APRIL via the Smad3 and ERK/CREB pathways in macrophages

  10. Results demonstrated that BMPRII and ActRII are the functional type II TGF-beta receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 cells.

  11. The coordinated activity of ActRIIA and BMPRII receptor subunits selectively mediates the chemotactic response to BMP7.

  12. Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 signal in patterning the axial vertebrae

  13. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation

  14. Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression.

  15. Overexpression of ARIP2 enhances endocytosis of ActRIIAs; data indicate that ARIP2 is a novel factor regulating cell surface ActRIIA expression and activin function.

  16. loss of Bmpr2 leads to the net gain of signaling by some, but not all, BMP ligands via the activation of ActRIIa

  17. ActRIIa is expressed in the early development of thymocytes.

  18. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal

Activin Receptor Type IIA (ACVR2A) Protein Profile

Protein Summary

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Gene names and symbols associated with ACVR2A

  • activin A receptor type 2A (ACVR2A)
  • activin A receptor type 2A (acvr2a)
  • activin A receptor type 2A (Acvr2a)
  • activin A receptor type 2A L homeolog (acvr2a.L)
  • activin A receptor type 2Aa (acvr2aa)
  • activin receptor IIA (Acvr2a)
  • actr2a protein
  • ACTRII protein
  • ActrIIa protein
  • Acvr2 protein
  • acvr2a protein
  • rActR-II protein
  • TactrII protein
  • wu:fa02e10 protein
  • XSTK9 protein

Protein level used designations for ACVR2A

activin receptor IIA , activin receptor type-2A , activin A receptor, type IIA , ACTR-IIA , activin receptor type IIA , type II activin receptor , activin A receptor, type II , activin receptor, type IIA , ACTRIIA , activin receptor type II , activin type 2 receptor , activin receptor IIa , etID22865.9

GENE ID SPECIES
397282 Sus scrofa
476140 Canis lupus familiaris
100216172 Xenopus (Silurana) tropicalis
100224301 Taeniopygia guttata
100583170 Nomascus leucogenys
92 Homo sapiens
29263 Rattus norvegicus
281598 Bos taurus
396324 Gallus gallus
443304 Ovis aries
399283 Xenopus laevis
553359 Danio rerio
11480 Mus musculus
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