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The protein encoded by Acsl3 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Additionally we are shipping Acsl3 Antibodies (75) and many more products for this protein.
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ACSL3 distribution closely overlapped with proteins involved in trafficking from the trans-Golgi network and endosomes. In contrast, the ACSL4 (show ACSL4 Proteins) localisation pattern more closely followed that of calnexin (show CANX Proteins) which is an endoplasmic reticulum resident chaperone.
Subcellular fractionation showed that at least 68% of ACSL3 remain at the ER even during extensive fatty acid supplementation. High resolution single molecule microscopy confirmed the abundance of cytoplasmic ACSL3 outside of LDs.
ACSL3 is essential for mutant KRAS lung cancer tumorigenesis in vivo and is highly expressed in human lung cancer
Study shows that ACSL3 contributes to intratumoral steroidogenesis by modulating the steroidogenic genes and plays an important role in the growth of castration-resistant prostate cancer.
ACLS4 and ACLS3 have roles in insulin (show INS Proteins) secretion
The prominent expression of ACSL3 in VSMC.
activation of fatty acid import is linked to the up-regulation of cellular long chain acyl-CoA synthetase activity and identify the long chain acyl-CoA (show GNPAT Proteins) syntheatse3 (Acsl3) as a novel host factor required for polio replication.
role of N-terminal region of acyl-CoA synthetase 3 in its function and localization on lipid droplets
expression of ACSL3 was induced by endoplasmic reticulum stress
Results suggest that initiation of Golgi export of Lyn (show LYN Proteins) involves association of ACSL3 with the Lyn (show LYN Proteins) C-lobe, which is exposed to the molecular surface in an open conformation.
ACSL3 expression is up-regulated in ob/ob mice and mice fed a high sucrose diet
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
acyl-CoA synthetase long-chain family member 3
, LACS 3
, long-chain acyl-CoA synthetase 3
, long-chain-fatty-acid--CoA ligase 3
, long-chain-fatty-acid--CoA ligase 3-like
, fatty-acid-Coenzyme A ligase, long-chain 3
, lignoceroyl-CoA synthase
, fatty acid Coenzyme A ligase, long chain 3
, brain acyl-CoA synthetase II