Acyl-CoA Synthetase Long-Chain Family Member 3 Proteins (Acsl3)

The protein encoded by Acsl3 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Additionally we are shipping Acsl3 Antibodies (78) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Acsl3 2181 O95573
Acsl3 74205 Q9CZW4
Rat Acsl3 Acsl3 114024 Q63151
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Top Acsl3 Proteins at

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 2 μg 11 to 12 Days

Acsl3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for Acyl-CoA Synthetase Long-Chain Family Member 3 (Acsl3) Interaction Partners

Human Acyl-CoA Synthetase Long-Chain Family Member 3 (Acsl3) interaction partners

  1. ACSL3 distribution closely overlapped with proteins involved in trafficking from the trans-Golgi network and endosomes. In contrast, the ACSL4 localisation pattern more closely followed that of calnexin which is an endoplasmic reticulum resident chaperone.

  2. Subcellular fractionation showed that at least 68% of ACSL3 remain at the ER even during extensive fatty acid supplementation. High resolution single molecule microscopy confirmed the abundance of cytoplasmic ACSL3 outside of LDs.

  3. ACSL3 is essential for mutant KRAS lung cancer tumorigenesis in vivo and is highly expressed in human lung cancer

  4. Study shows that ACSL3 contributes to intratumoral steroidogenesis by modulating the steroidogenic genes and plays an important role in the growth of castration-resistant prostate cancer.

  5. ACLS4 and ACLS3 have roles in insulin secretion

  6. The prominent expression of ACSL3 in VSMC.

  7. activation of fatty acid import is linked to the up-regulation of cellular long chain acyl-CoA synthetase activity and identify the long chain acyl-CoA syntheatse3 (Acsl3) as a novel host factor required for polio replication.

  8. role of N-terminal region of acyl-CoA synthetase 3 in its function and localization on lipid droplets

  9. expression of ACSL3 was induced by endoplasmic reticulum stress

  10. Results suggest that initiation of Golgi export of Lyn involves association of ACSL3 with the Lyn C-lobe, which is exposed to the molecular surface in an open conformation.

  11. Results suggest that liver X receptors play a regulatory role in fatty acid metabolism by direct regulation of ACSL3 in human placental trophoblast cells.

  12. ACSL3 is a novel molecular target of PPARdelta in HepG2 cells; there is a regulatory mechanism for ACSL3 transcription in liver tissue

  13. Sequence analysis of genomic clones demonstrates that the human ACS3 gene spans at least 80.6 kb and contains 17 exons.

  14. Repression of FAS mRNA expression is the consequence of feedback inhibition of FAS expression by long chain fatty acyl-CoAs, which are formed by FACL3 during its upregulation by vitamin D3in prostate cancer cells.

  15. Oncostatin M directly lowers the plasma triglycerides in hyperlipidemia by stimulating the transcription of ACSL3/5 in the liver.

  16. Data suggest that endogenous FATP4 does not function to translocate fatty acids across the plasma membrane, but functions more as a very long-chain acyl-CoA synthetase.

  17. Small interfering RNA targeting ACSL3 inhibits secretion of hepatitis c virus from human hepatoma-derived cells

  18. Data suggest that methylated ACSL3 5'CpG islands in umbilical cord white blood cell DNA may be a surrogate endpoint for transplacental polycyclic aromatic hydrocarbon exposure and/or a potential biomarker for environmentally-related asthma.

Mouse (Murine) Acyl-CoA Synthetase Long-Chain Family Member 3 (Acsl3) interaction partners

  1. ACSL3 expression is up-regulated in ob/ob mice and mice fed a high sucrose diet

Acsl3 Protein Profile

Protein Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Acsl3

  • acyl-CoA synthetase long-chain family member 3 (ACSL3)
  • acyl-CoA synthetase long chain family member 3 (ACSL3)
  • acyl-CoA synthetase long chain family member 3b (acsl3b)
  • acyl-CoA synthetase long chain family member 3a (acsl3a)
  • AcsL3 (acsL3)
  • acyl-CoA synthetase long-chain family member 3 (acsl3)
  • acyl-CoA synthetase long-chain family member 3 (Acsl3)
  • AMP-dependent synthetase and ligase family protein (LACS3)
  • 2610510B12Rik protein
  • Acs3 protein
  • acsl3 protein
  • C85929 protein
  • F15H21.7 protein
  • F15H21_7 protein
  • fa07a08 protein
  • Facl3 protein
  • im:7155129 protein
  • long-chain acyl-CoA synthetase 3 protein
  • Pro2194 protein
  • si:dkey-20f20.5 protein
  • si:dkeyp-109h9.2 protein
  • wu:fa07a08 protein
  • wu:fb34c03 protein

Protein level used designations for Acsl3

acyl-CoA synthetase long-chain family member 3 , AcsL3 , LACS 3 , long-chain acyl-CoA synthetase 3 , long-chain-fatty-acid--CoA ligase 3 , long-chain-fatty-acid--CoA ligase 3-like , fatty-acid-Coenzyme A ligase, long-chain 3 , lignoceroyl-CoA synthase , fatty acid Coenzyme A ligase, long chain 3 , brain acyl-CoA synthetase II

424810 Gallus gallus
459974 Pan troglodytes
478927 Canis lupus familiaris
559656 Danio rerio
567157 Danio rerio
7499741 Desulfobacterium autotrophicum HRM2
100174659 Pongo abelii
100227254 Taeniopygia guttata
100358351 Oryctolagus cuniculus
100482396 Ailuropoda melanoleuca
100566291 Anolis carolinensis
100593479 Nomascus leucogenys
2181 Homo sapiens
100233169 Sus scrofa
100138312 Bos taurus
74205 Mus musculus
114024 Rattus norvegicus
842748 Arabidopsis thaliana
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