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AGGF1 encodes an angiogenic factor that promotes proliferation of endothelial cells. Additionally we are shipping AGGF1 Kits (37) and AGGF1 Proteins (10) and many more products for this protein.
Showing 10 out of 97 products:
Polyclonal AGGF1 Primary Antibody for IHC (fro), WB - ABIN540425
Tian, Kadaba, You, Liu, Timur, Yang, Chen, Szafranski, Rao, Wu, Housman, DiCorleto, Driscoll, Borrow, Wang: Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. in Nature 2004
Bmp-induced activation of beta-catenin through Aggf1 regulates caudal vein development by promoting the Nr2f2-dependent differentiation of venous endothelial cells and their survival.
aggf1 is involved in differentiation of both hematopoietic and endothelial lineages and acts upstream of scl, fli1, and etsrp in specification of hemangioblasts
Our study establishes AGGF1 as an angiogenic factor with an important role in the specification of vein identity and suggests that AGGF1-mediated AKT signaling is responsible for establishing venous cell fate
Aggf1 has a role in regulating vascular injury.
High expression of AGGF1 predicts poor prognosis in gastric cancer patients.
AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians.
Overexpression of AGGF1 is correlated with angiogenesis in hepatocellular carcinoma.
AGGF1 reduces myocardial apoptosis and inflammation and enhances angiogenesis, leading to decreased infarct size after I/R injury.
results of this study indicate that hypoxia down-regulates expression of the AGGF1 protein, but not AGGF1 mRNA, by inducing expression of miR-27a
AGGF1 potently attenuated TNF-alpha triggered NF-kappaB pathway, as indicated by the decreased promoter activity, nuclear distribution and phosphorylation of NF-kappaB p65 subunit as well as the increased protein level of IkappaBalpha.
analysis of sphingolipid modulation of angiogenic factor expression in neuroblastoma
results define VG5Q as an angiogenic factor, establish VG5Q as a susceptibility gene for Klippel-Trenaunay syndrome, and show that increased angiogenesis is a molecular pathogenic mechanism of KTS
VG5Q, E133K is a mutation that causes Klippel-Trenaunay and other overgrowth syndromes.
This review describes the somatic mutation for angiogenic factor VG5Q, which may be the cause of the multisystem disorder Klippel-Trenaunay syndrome.
identified two tagSNPs, rs13155212 and rs7704267 that capture information for all common variants in AGGF1 as a candidate susceptibility gene for Klippel-Trenaunay syndrome
Knockdown of GATA1 expression by siRNA reduced expression of AGGF1, and resulted in endothelial cell apoptosis and inhibition of vessel formation.
AGGF1 protein therapy is effective in blocking neointimal formation after vascular injury by regulating a novel AGGF1-MEK1/2-ERK1/2-Elk-myocardin-SRF/p27 signaling pathway.
Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)
Data indicate that angiogenic factor Aggf1+/- knockout (KO) mice show reduced autophagy, which was associated with inhibition of angiogenesis and larger infarct areas.
Mechanistically, Aggf1 activated the expression of gluconeogenesis gene and skewed the insulin signaling pathway to induce insulin resistance. Taken together, our data suggest that Aggf1 plays a role in steatosis in vivo and as such may be a new target in the development of therapeutics solutions against steatosis.
Sphingolipid modulation of angiogenic factor expression in neuroblastoma
This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.
angiogenic factor with G patch and FHA domains 1
, angiogenic factor VG5Q
, G patch domain-containing protein 7
, vasculogenesis gene on 5q protein