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The protein encoded by ANG is an exceedingly potent mediator of new blood vessel formation. Additionally we are shipping Angiogenin Kits (88) and Angiogenin Proteins (35) and many more products for this protein.
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Association analyses revealed the significant associations (P < 0.05) between the porcine ANG g. 149G>T polymorphism and mean corpuscular volume (MCV), mean corpuscular hemoglobin (show HBB Antibodies) (MCH (show PMCH Antibodies)), mean platelet volume (MPV) and platelet-large cell ratio (P-LCR).
Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 (show MMP2 Antibodies) through modulation of DNMT3b (show DNMT3B Antibodies) functions.
(31) RRR (show RRS1 Antibodies)(33) and (50) KRSIK(54) motifs of angiogenin might play a critical role in the regulation of p53 (show TP53 Antibodies)-mediated apoptosis and angiogenesis in cancer cells.
Study shows that plexin-B2 (PLXNB2 (show PLXNB2 Antibodies)) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.
Delivery of the therapeutic human genes VEGF (show VEGFA Antibodies) and ANG using an adenoviral vector improved functional recovery after traumatic spinal cord injury in a rat model. Immunofluorescent analysis of the post-treatment spinal cord suggested that the positive effect of Ad5 (show PSEN2 Antibodies)-VEGF (show VEGFA Antibodies)+Ad5 (show PSEN2 Antibodies)-ANG transduction on recovery of locomotor function may be due to the action of glial cells on motor neurons.
Ang down-regulate the expression of Col (show HDAC1 Antibodies)-I, alpha-SMA (show SMN1 Antibodies) and TGF-beta1 (show TGFB1 Antibodies)/Smad2 (show SMAD2 Antibodies)/3 and subsequently inhibits fibroblast-myofibroblast transition.
Ang,Tie1 (show TIE1 Antibodies) and Tie2 (show TEK Antibodies) play roles in vascular development and pathogenesis of vascular diseases.[review]
Results indicate that angiogenin (ANG) plays a critical role in regulating angiogenesis and follicle survival in xenografted human ovarian tissues.
we found that ANG plays an important role in EMT (show ITK Antibodies) in squamous cell lung carcinoma and may be a valuable therapeutic target for squamous cell lung carcinoma
There is Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk.
ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation.
angiogenin and ILK (show ILK Antibodies) signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth
Our data provide new insights into the paracrine activities of angiogenin in the nervous system, and further highlight the critical role of non-neuronal cells in the pathogenesis of Amyotrophic lateral sclerosis
RNase 4 (show RNASE4 Antibodies) and RNase 5/ang 1 (show ANGPT1 Antibodies) are unique among the RNase A (show RNASE1 Antibodies) ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.
ANG plays an important role in neurite pathfinding and this has implications for amyotrophic lateral sclerosis.
Angiogenin mRNA was expressed in murine skin in a hair-cycle dependent manner, with maximum levels observed at the late anagen.
All three types of the ANG inhibitor suppress rRNA transcription of the prostate luminal epithelial cells and inhibit AKT (show AKT1 Antibodies)-induced PIN (show DYNLL1 Antibodies), indicating an essential role of ANG in AKT (show AKT1 Antibodies)-mediated cell proliferation and survival.
Murine angiogenin mRNA and protein are upregulated in motoneurons in response to hypoxia, and that Hypoxia-Inducible Factor 1 (show HIF1A Antibodies) is sufficient and required to upregulate angiogenin expression during hypoxia.
This study is the first to demonstrate that hypoxia upregulates Ang1 (show ANGPT1 Antibodies) expression via HIF2alpha (show EPAS1 Antibodies)-mediated transcriptional activation in pericytes, which plays a key role in angiogenesis.
rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infafrction.
bovine angiogenin is the substance mainly responsible for the inhibitory effect of bovine milk on osteoclast-mediated bone resorption
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
, epididymis luminal protein 168
, ribonuclease 5
, angiogenin, ribonuclease A family, member 1
, angiogenin ribonuclease 1