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APLNR encodes a member of the G protein-coupled receptor gene family. Additionally we are shipping Apelin Receptor Kits (19) and Apelin Receptor Proteins (5) and many more products for this protein.
Showing 10 out of 165 products:
Human Monoclonal Apelin Receptor Primary Antibody for CyTOF, FACS - ABIN4899111
Bahrami, Pagh, Ejegod, Duch, Tolstrup, Pedersen: Construction of a gammaretrovirus with a novel tropism and wild-type replication kinetics capable of using human APJ as entry receptor. in Journal of virology 2012
Show all 2 Pubmed References
Human Polyclonal Apelin Receptor Primary Antibody for FACS, IF (p) - ABIN740160
Ustunel, Acar, Gemici, Ozbey, Edizer, Soylu, Tepekoy, Izgut-Uysal: The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart. in Acta histochemica 2014
Show all 2 Pubmed References
Hamster Monoclonal Apelin Receptor Primary Antibody for IHC, IHC (p) - ABIN4254280
Cui, Mao, Yi, Wang, Zhang, Xie, Wu, Liao, Zhou, Meng, Yuan, Liao: Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways. in Amino acids 2010
Human Monoclonal Apelin Receptor Primary Antibody for FACS - ABIN4895622
Yu, Hirst, Costa, Ng, Schiesser, Gertow, Stanley, Elefanty: APELIN promotes hematopoiesis from human embryonic stem cells. in Blood 2012
APJ receptor in granulosa cells and both apelin (show APLN Antibodies) and the APJ receptor in theca tissues are expressed in bovine ovary.
The data suggest that apelin (show APLN Antibodies)/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.
Internalization does not appear to contribute to the desensitization of APJ-mediated ppERK1/2 activation.
the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors.
These results demonstrate a new pharmacologic property of protamine-blockade of APJ-that could explain some adverse effects observed in protamine-treated patients, and that the established antiangiogenic activity of protamine would rely on APJ antagonism.
Apelin (show APLN Antibodies)-36-[L28C(30kDa (show TAF10 Antibodies)-PEG (show PAEP Antibodies))] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation
Results show that obese mice had significantly lower mRNA and protein expressions of apelin (show APLN Antibodies)/ APJ in skeletal muscles than the normal body weight mice.
These results demonstrate that overexpression of APJ in cardiomyocytes has adverse effects on cardiac function in male and non-pregnant mice and that lactation contributes to the development of postpartum cardiomyopathy in the heart with APJ overexpression.
Endothelial CXCR4 (show CXCR4 Antibodies) is negatively regulated by miR (show MLXIP Antibodies)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Antibodies)/APLNR signalling.
apelin (show APLN Antibodies) is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 (show SFRP1 Antibodies) by apelin receptor(+) ECs
Findings demonstrate a stimulatory role for the islet cell apelin (show APLN Antibodies)-APJ signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced beta-cell hyperplasia.
ERG (show ERG Antibodies) and APLNR are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG (show ERG Antibodies)-APLNR signaling is crucial for the development of pulmonary veno-occlusive disease.
The APLNR A445C polymorphism was not associated with diabetic retinopathy in a sample of the Tunisian population, but the CC genotype carrier patients with DR had a high total cholesterol concentration.
APLN (show APLN Antibodies) and APLNR are present in human ovarian cells and APLN (show APLN Antibodies) increases IGF1 (show IGF1 Antibodies)-induced steroidogenesis in granulosa cells through an increase in HSD3B (show HSD3B1 Antibodies) protein expression and activation of the MAPK3 (show MAPK3 Antibodies)/1 and Akt (show AKT1 Antibodies) pathways. Therefore, APLN (show APLN Antibodies) and APLNR may play a role in human follicular development and the pathogenesis of PCOS.
The apelin (show APLN Antibodies)/APLNR axis regulates cholangiocarcinoma cell proliferation and tumor angiogenesis.
Data suggest that the differential expression of Apelin (show APLN Antibodies) and Apelin receptor APJ yields a "self-generated" gradient mechanisms that accelerates the extension of the sprout.
The aim of this study was to evaluate if polymorphisms of APLN (show APLN Antibodies) and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients.
review of the important role of the Apelin (show APLN Antibodies)/APJ system in pathological angiogenesis
The optimal gene-gene interaction model for both males and females with regard to hypertension was apelin (show APLN Antibodies) rs3761581-apelin (show APLN Antibodies) rs3115757-APJ rs7119375. In conclusion, gene polymorphisms of the apelin (show APLN Antibodies)-APJ system are associated with susceptibility to hypertension.
Up-regulation of apelin (show APLN Antibodies) and APJ expression plays an important role in cardioprotection from myocardial ischemia/reperfusion injury.
These findings suggested that Apelin (show APLN Antibodies)/APLNR signaling may be used as a potential therapeutic target for hypoxic/ischemic injury.
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
angiotensin II receptor-like 1
, G-protein coupled receptor APJ
, angiotensin receptor-like 1
, angiotensin receptor-related protein
, apelin receptor
, APJ (apelin) receptor
, APJ receptor
, G protein-coupled receptor APJ
, G-protein coupled receptor HG11
, HG11 orphan receptor