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APLNR encodes a member of the G protein-coupled receptor gene family. Additionally we are shipping Apelin Receptor Kits (21) and Apelin Receptor Proteins (6) and many more products for this protein.
Showing 10 out of 185 products:
Human Polyclonal Apelin Receptor Primary Antibody for FACS, IF (p) - ABIN740160
Ustunel, Acar, Gemici, Ozbey, Edizer, Soylu, Tepekoy, Izgut-Uysal: The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart. in Acta histochemica 2014
Show all 2 Pubmed References
Human Monoclonal Apelin Receptor Primary Antibody for CyTOF, FACS - ABIN4899111
Bahrami, Pagh, Ejegod, Duch, Tolstrup, Pedersen: Construction of a gammaretrovirus with a novel tropism and wild-type replication kinetics capable of using human APJ as entry receptor. in Journal of virology 2012
Show all 2 Pubmed References
Human Monoclonal Apelin Receptor Primary Antibody for FACS - ABIN4895622
Yu, Hirst, Costa, Ng, Schiesser, Gertow, Stanley, Elefanty: APELIN promotes hematopoiesis from human embryonic stem cells. in Blood 2012
Hamster Monoclonal Apelin Receptor Primary Antibody for IHC, IHC (p) - ABIN4254280
Cui, Mao, Yi, Wang, Zhang, Xie, Wu, Liao, Zhou, Meng, Yuan, Liao: Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways. in Amino acids 2010
APJ receptor in granulosa cells and both apelin (show APLN Antibodies) and the APJ receptor in theca tissues are expressed in bovine ovary.
The data suggest that apelin (show APLN Antibodies)/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.
the expression of APLNR (APJ/AGTRL1), the only known receptor for apelin (show APLN Antibodies), is predominantly restricted to the endothelial cells.
The ELA-APJ axis protects from pressure overload-induced heart failure possibly via suppression of ACE (show ACE Antibodies) expression and pathogenic angiotensin II signaling.
Internalization does not appear to contribute to the desensitization of APJ-mediated ppERK1/2 activation.
the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors.
These results demonstrate a new pharmacologic property of protamine-blockade of APJ-that could explain some adverse effects observed in protamine-treated patients, and that the established antiangiogenic activity of protamine would rely on APJ antagonism.
Apelin (show APLN Antibodies)-36-[L28C(30kDa (show TAF10 Antibodies)-PEG (show PAEP Antibodies))] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation
Results show that obese mice had significantly lower mRNA and protein expressions of apelin (show APLN Antibodies)/ APJ in skeletal muscles than the normal body weight mice.
These results demonstrate that overexpression of APJ in cardiomyocytes has adverse effects on cardiac function in male and non-pregnant mice and that lactation contributes to the development of postpartum cardiomyopathy in the heart with APJ overexpression.
Endothelial CXCR4 (show CXCR4 Antibodies) is negatively regulated by miR (show MLXIP Antibodies)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Antibodies)/APLNR signalling.
apelin (show APLN Antibodies) is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 (show SFRP1 Antibodies) by apelin receptor(+) ECs
Apelin receptor signaling is critical for endothelial cell polarization.
Studies indicate that the Elabela-APJ (apelin receptor) axis may protect against pressure overload-induced heart failure.
The high APJ expression has significantly higher rates of tumor invasion, local lymph node, and distant metastasis (all p < 0.001).
The mutation of polymorphism rs10501367 in APJ gene decreased risk of hypertension in Chinese males.
these observations suggest apelin (show APLN Antibodies)-APJ signaling in hepatocytes functions to protect against lipid accumulation in liver through two signaling pathways, that is, via AMPK (show PRKAA1 Antibodies) activation and PPARalpha (show PPARA Antibodies) induction.
916 ischemic stroke patients were recruited for the study. For age at ischemic stroke onset, no significant association was identified with the variant rs9943582 of APLNR in any genetic model. In addition, the variant was not strongly associated with recurrence and death risk of ischemic stroke, as shown by the results.
Studies suggest that apelin (show APLN Antibodies)/APJ system may be applied to the treatment of cancers by regulating apoptosis, which may play a vital role in anticancer therapy [review].
Crystal structure of human APJR shows structural basis for apelin (show APLN Antibodies) recognition and binding
mutation of promoter polymorphism rs7119375 in APJ gene was significantly associated with elevated SBP (show SHBG Antibodies) and increased hypertension risk in Chinese women.
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
angiotensin II receptor-like 1
, G-protein coupled receptor APJ
, angiotensin receptor-like 1
, angiotensin receptor-related protein
, apelin receptor
, APJ (apelin) receptor
, APJ receptor
, G protein-coupled receptor APJ
, G-protein coupled receptor HG11
, HG11 orphan receptor