anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1 (APOBEC1) Antibodies

APOBEC1 encodes a member of the cytidine deaminase enzyme family. Additionally we are shipping APOBEC1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APOBEC1 339 P41238
APOBEC1 11810 P51908
APOBEC1 25383 P38483
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Top anti-APOBEC1 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-APOBEC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Liver 100 μL 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB ABIN334347 (1µg/ml) staining of Mouse Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB ApoBEC1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL 11 to 12 Days
$238.67
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit APC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

Top referenced anti-APOBEC1 Antibodies

  1. Human Polyclonal APOBEC1 Primary Antibody for IHC (p), ELISA - ABIN543435 : Chester, Somasekaram, Tzimina, Jarmuz, Gisbourne, OKeefe, Scott, Navaratnam: The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. in The EMBO journal 2003 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal APOBEC1 Primary Antibody for ELISA, WB - ABIN449571 : Lau, Chan: Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. in The Journal of biological chemistry 2003 (PubMed)

More Antibodies against APOBEC1 Interaction Partners

Human Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1 (APOBEC1) interaction partners

  1. Our findings propose APOBEC1 and isoform b as the potential endogenous mutators implicated in cancer in-frame indels and pave the way for their use as novel prognostic tumor markers.

  2. Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells.

  3. AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review)

  4. Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models.

  5. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in esophageal squamous cell carcinoma.

  6. hnRNPQ6 is required for APOBEC1-enhanced IL8 production.

  7. Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4).

  8. The hypermutation activity of APOBEC-1 was decreased to background levels by a single point APOBEC-1 mutation of P29F or E181Q, while 50% of wild-type control editing at the normal site was retained.

  9. The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation.

  10. Identified two novel variants, rs1349411 (APOBEC1) and rs1424032, for serum apoB levels in Mexicans.

  11. C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme

  12. expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing

  13. determination of multifunctional cycle and suppression of nonsense-mediated decay

  14. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling

  15. apobec-1-mediated apoB mRNA editing is regulated by BAG-4

  16. Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48.

  17. APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase

  18. No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected.

  19. Demonstrates the presence of a 36-aa peptide (isoform 2) derived from this gene in adult small intestinal villi using immunocytochemical analysis.

Mouse (Murine) Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1 (APOBEC1) interaction partners

  1. APOBEC1-mediated RNA editing occurs within brain microglia cells and is key to maintaining their resting status. Apobec1-/- mice display age-related signs of CNS neurodegeneration.

  2. Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.

  3. substantial rearrangement/duplication of transgene elements is present, and transgene integration was accompanied by the deletion of a 19,500 bp fragment of genomic DNA that contains the promoter, exon 1 and part of intron 1 of the APOBEC1 complementation factor (A1cf) gene, as well as several elements that are predicted to regulate chromosomal architecture

  4. The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney.

  5. Apobec-1-dependent C-to-U RNA editing exerts broad functional effects in a tissue-specific manner.

  6. RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing.

  7. In contrast to in vitro results, APOBEC1 neither inhibited nor significantly drove the molecular evolution of Friend retrovirus in wild type or APOBEC1 knockout mice.

  8. Individual genetic variability at the Apobec1 locus results in differential rates of C-to-U(T) editing in murine macrophages; with mouse strains expressing mostly a truncated alternative transcript isoform of Apobec1 exhibiting lower rates of editing.

  9. The transgenic rescue of intestinal apobec-1 expression restores C-to-U RNA editing of apoB mRNA in vivo, including the canonical site at position 6666 and also at approximately 20 other newly identified downstream sites present in WT mice.

  10. Results suggest that apo B mRNA editing protein (Apobec1 cytidine deaminase) plays a central role in controlling testicular germ cell tumors susceptibility in both a conventional and a transgenerational manner.

  11. The transcriptomics approach to RNA editing presented in this study dramatically expands the list of APOBEC1 mRNA editing targets and reveals a novel cellular mechanism for the modification of transcript 3' UTRs.

  12. LDL receptor and the apolipoprotein B mRNA editing enzyme Apobec1 are regulated via calcium signaling in mechanistic response to genetic, mechanical, and environmental insults that trigger an imbalance of intracellular calcium homeostasis

  13. studies establish the existence of preferential degradation of intestinal apolipoprotein B-100 and subtle defects in triglyceride secretion in apolipoprotein B editing complex 1-/- mice

  14. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling

  15. apobec-1-mediated apoB mRNA editing is regulated by BAG-4

  16. RNA editing of this protein is unable to induce somatic hypermutation in mammalian cells.

  17. Lipopolysaccharide increases intestinal stem cell survival through apobec-1-mediated regulation of cyclooxygenase-2 messenger RNA stability.

  18. Deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation.

  19. Murine APOBEC1 is a hypermutator of both RNA and single-stranded DNA in vivo, which could exert occasional side effects upon overexpression.

  20. the AU-rich RNA binding-protein Apobec-1 mediates post-transcriptional regulation of Cyp7a1 expression and influences susceptibility to diet-induced gallstone formation

Rabbit Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1 (APOBEC1) interaction partners

  1. A moderate reduction of the APOBEC1 dependent editing induces a lean phenotype at least in the rabbit species.

APOBEC1 Antigen Profile

Protein Summary

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.

Gene names and symbols associated with APOBEC1

  • apolipoprotein B mRNA editing enzyme catalytic subunit 1 (APOBEC1) antibody
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec1) antibody
  • apolipoprotein B mRNA editing enzyme catalytic subunit 1 (Apobec1) antibody
  • APOBEC-1 antibody
  • APOBEC1 antibody
  • BEDP antibody
  • Cdar1 antibody
  • HEPR antibody
  • REPR antibody

Protein level used designations for APOBEC1

C->U-editing enzyme APOBEC-1 , apolipoprotein B mRNA editing enzyme complex-1 , apolipoprotein B mRNA-editing enzyme 1 , apolipoprotein B editing complex 1 , Apolipoprotein B editing protein , apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 , apolipoprotein B mRNA editing enzyme complex 1 , apolipoprotein B mRNA editing protein , Apolipoprotein B mRNA-editing enzyme 1 , apolipoprotein B mRNA editing catalytic subunit-1

GENE ID SPECIES
339 Homo sapiens
11810 Mus musculus
25383 Rattus norvegicus
486699 Canis lupus familiaris
516043 Bos taurus
554187 Monodelphis domestica
715554 Macaca mulatta
748253 Pan troglodytes
100009191 Oryctolagus cuniculus
101825976 Mesocricetus auratus
100734070 Cavia porcellus
100061100 Equus caballus
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