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Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation.
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Human Polyclonal ACIN1 Primary Antibody for ICC, ELISA - ABIN1001730
Zamzami, Kroemer: Condensed matter in cell death. in Nature 1999
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Human Polyclonal ACIN1 Primary Antibody for ICC, ELISA - ABIN1001731
Sahara, Aoto, Eguchi, Imamoto, Yoneda, Tsujimoto: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. in Nature 1999
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We conclude that RNPS1 (show RNPS1 Antibodies) is a key factor for the quality control of mRNAs that is essential for the phenotypes including cell division.
Genome-wide identification of RNA targets of Acinus revealed its role in splicing regulation as well as its involvement in other cellular pathways, including cell cycle progression.
acinus L was identified as a potential novel mTORC1 target.
Differences in the nuclear localization of Acinus-S' and Acinus-L may suggest that these two isoforms have different functional roles.
the ligand-dependent splicing activity of Acinus is related to the retinoic acid-activated retinoic acid receptor (show RARA Antibodies)
An electronegative region on acinusS restricts SRPK2 (show SRPK2 Antibodies) phosphorylation to a single specific site.
Chronic low-dose radiation increases the levels of AKT (show AKT1 Antibodies) and acinus proteins via NF-kappaB (show NFKB1 Antibodies) activation
Akt (show AKT1 Antibodies) phosphorylation of acinus on serine 422 and 573 results in its resistance to caspase (show CASP3 Antibodies) cleavage in the nucleus and the inhibition of acinus-dependent chromatin condensation.
Acinus is not involved in DNA condensation but rather has a role in internucleosomal DNA cleavage during programmed cell death
We found hypermethylation of the ACIN1 gene in early stage lung adenocarcinoma. The role of methylation status in the development and malignant transformation of lung adenocarcinoma requires clarification.
gp70 (show EMB Antibodies) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus and MCM2 (show MCM2 Antibodies) resulting in the activation of DNA-PK to phosphorylate P53 (show TP53 Antibodies).
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
apoptotic chromatin condensation inducer in the nucleus, b
, apoptotic chromatin condensation inducer in the nucleus, a
, apoptotic chromatin condensation inducer 1
, apoptotic chromatin condensation inducer in the nucleus
, apoptotic chromatin condensation inducer in the nucleus-like
, functional spliceosome-associated protein 152