Arachidonate 5-Lipoxygenase Proteins (ALOX5)

ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Antibodies (220) and ALOX5 Kits (71) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX5 240 P09917
ALOX5 11689 P48999
ALOX5 25290 P12527
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Top ALOX5 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$630.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$325.44
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
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Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 15 to 18 Days
$672.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,956.33
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Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 18 Days
$668.03
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
Baculovirus Human Un-conjugated   500 units Log in to see 9 to 11 Days
$640.29
Details

ALOX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Arachidonate 5-Lipoxygenase (ALOX5) Interaction Partners

Human Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. our work shows that ALOX5 plays a moderate anti-tumor role and functions as a drug sensitizer, with a therapeutic potential, in MLL-rearranged AML.

  2. Study shows that higher COX-2 and ALOX5 expression in colorectal cancer (CRC) tissues was correlated with poorer prognosis in patients with CRC. Also, MiR-216a-3p was shown to directly bind to there 3'-UTR and inversely regulates their protein levels modulating CRC cell proliferation.

  3. Indicate a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis.

  4. Our data reveal that 5-LO, which is required for leukotriene production and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dependent recognition of apoptotic cancer cells.

  5. the influence of TGFbeta/SMADs on MLL- and MLL-AF4-mediated 5-LO promoter activation

  6. The knockdown of arachidonate 5-lipoxygenase (Alox5) gene can induce the decreased levels of bcl/abl mRNA and BCR/ABL fusion protein in the K562/ADM cells and increased apoptosis rate.

  7. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.

  8. This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke.

  9. The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment

  10. ROS production induced by the 5-LO pathway mediates the anti-cancer effects of docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine on head and neck squamous cell carcinoma cells.

  11. Specific inhibitors of COX-2 and 5-LOX decreased formation of HKD2 and HKE2 Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved

  12. The observation that the coexpression of FLAP with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP.

  13. Polymorphisms in the 5-Lipoxygenase is associated with Incident Myocardial Infarction.

  14. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera

  15. Adipose tissue eicosapentaenoic acid and arachidonic acid and the ALOX-5 tandem repeat polymorphism did not significantly interact to affect the risk of myocardial infarction.

  16. coexpression of the isoforms inhibited or stimulated 5-LO-WT expression in transiently and stably transfected HEK293T cells suggesting that the isoforms have other functions than canonical leukotriene biosynthesis

  17. a novel putative protein isoform of human 5-LO that lacks exon 4, termed 5-LODelta4, was identified.

  18. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 levels and death of RPE cells undergoing oxidative stress.

  19. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  20. Copy number variation in ALOX5 is associated with NSAIDs-induced urticaria and/or angioedema.

Mouse (Murine) Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. it was suggested that 5-LO in monocytes played a pivotal role in monocyte-macrophage differentiation and subsequent infiltration of macrophage in neointima, leading to vascular remodeling after vascular injury.

  2. the up-regulation of the ALOX5 is responsible for the Homocysteine-dependent worsening of the Alzheimer's disease phenotype in a relevant mouse model of the disease.

  3. Our data showed that besides the high parasite burden and lack of microbicidal molecules, an imbalance with high COX-2 and 5-LOX eicosanoid expression and a lack of regulatory PPAR-gamma cytoplasm-to-nucleus translocation in macrophages were observed in mice that develop cerebral malaria.

  4. Data indicate that 5-lipoxygenase (5-LO)/leukotriene B4 (LTB4) axis orchestrates graft-versus-host disease (GVHD) development and suggest it could be a target for the development of therapeutic strategies for GVHD treatment.

  5. Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.

  6. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL

  7. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera

  8. Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.

  9. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  10. Data suggest that miR-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6) or TNFa (tumor necrosis factor-alpha).

  11. Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.

  12. GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.

  13. SHH-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 modulate Dectin-1-induced inflammatory cytokines.

  14. involvement of lipoxygenase pathways in TNF-alpha-induced production of cytokines and chemokines

  15. explored the relationship between 5-LO and central and peripheral eosinophilia in an asthma model using PAS or BALB/c mice and 5-LO-deficient mutants

  16. ALOX5 deficiency prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

  17. 5-LO activation coordinates the inflammatory immune response involved in the control of visceral leishmaniasis.

  18. 5-LO(-/-) mice subjected to kidney insult presented lower macrophage infiltration and higher levels of IL-10 than wild-type mice.

  19. Alox5 affects the osteogenic and adipogenic abilities of iPSCs in vivo and the effect of Cox2 inhibition in this system.

  20. Data show that resolvin D1 decrease nuclear 5-lipoxygenase (5-LOX) and the leukotrienes LTB4:LXA4 ratio by macrophages lacking calcium-sensitive kinase calcium-calmodulin-dependent protein kinase II (CaMKII).

Horse (Equine) Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. [5-lipoxygenase; 5-lox] protein expression and enzyme activity of 5-LOX were significantly higher in horses harbouring encysted larvae in comparison with horses free of encysted larvae

  2. Increased PGE2 production led to reduction in 5-LO products in LPS-treated equine whole blood via IL-1b.

ALOX5 Protein Profile

Protein Summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ALOX5

  • arachidonate 5-lipoxygenase (ALOX5)
  • arachidonate 5-lipoxygenase (Alox5)
  • arachidonate 5-lipoxygenase a (alox5a)
  • arachidonate 5-lipoxygenase (AFUA_4G02770)
  • arachidonate 5-lipoxygenase (AOR_1_1362014)
  • Arachidonate 5-lipoxygenase (lox5)
  • 5-LO protein
  • 5-LOX protein
  • 5LO protein
  • 5LPG protein
  • 5LX protein
  • AI850497 protein
  • F730011J02 protein
  • LOG5 protein
  • lox5 protein
  • LOX5A protein
  • si:dkey-194n13.2 protein

Protein level used designations for ALOX5

LOX-5 , arachidonic 5-lipoxygenase alpha-10 isoform , arachidonic 5-lipoxygenase delta-10-13 isoform , arachidonic 5-lipoxygenase delta-13 isoform , arachidonic 5-lipoxygenase delta-p10 isoform , arachidonic acid 5-lipoxygenase , leukotriene A4 synthase , 5-lipoxygenase , 5 - Lipoxygenase , 5-LO , LOX2 , arachidonate 5-lipoxygenase , Arachidonate 5-lipoxygenase

GENE ID SPECIES
240 Homo sapiens
11689 Mus musculus
25290 Rattus norvegicus
404074 Bos taurus
477753 Canis lupus familiaris
567204 Danio rerio
3503886 Aspergillus fumigatus Af293
5994193 Aspergillus oryzae RIB40
100194803 Salmo salar
100718093 Cavia porcellus
423769 Gallus gallus
100156205 Sus scrofa
100341714 Oryctolagus cuniculus
101117390 Ovis aries
101839970 Mesocricetus auratus
100062042 Equus caballus
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