Arachidonate 5-Lipoxygenase Proteins (ALOX5)

ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Antibodies (230) and ALOX5 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX5 240 P09917
ALOX5 11689 P48999
ALOX5 25290 P12527
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Top ALOX5 Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Escherichia coli (E. coli) Rat His tag 100 μg 15 to 18 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Mouse His tag   100 μg 15 to 18 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Human Un-conjugated   200 μU 2 to 3 Days
Escherichia coli (E. coli) Rat Un-conjugated   100 μg 11 to 18 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days

ALOX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Arachidonate 5-Lipoxygenase (ALOX5) Interaction Partners

Human Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. Decreased prostaglandin catabolism and increased 5-lipoxygenase expression was associated with aggressive subtypes of endometrial cancer.

  2. Data suggest that the KKK motif is a governor of 5-LOX enzyme activity and the helper protein FLAP is required to sufficiently relieve its auto-suppression for effective leukotrienes (LT) synthesis. Moreover, substrate sequestering and/or handoff by FLAP may limit the rate of LTA4 synthesis by the hyperactive triple K mutant.

  3. Human cytomegalovirus induced both COX-2 and 5-LO proteins but not transcripts in breast cancer.

  4. 5-LOX does not react with 5,15-diHpETE, although it can produce lipoxin A4 when 15-HpETE is the substrate. In contrast, both 12-LOX and 15-LOX-1 react with 5,15-diHpETE, forming specifically lipoxin B4.

  5. High lox5 expression is associated with dysmenorrhea.

  6. Our study showed that ALOX5 rs12762303 was associated with fasting blood glucose (FBG) levels but not with myocardial infarction in Chinese population

  7. ALOX5 rs4987105 polymorphism is associated with type 2 diabetes.

  8. PFN1 down-regulated the expression of lipoxygenase arachidonate 5-lipoxygenase (ALOX5) in human endometrial stromal cells and THP-1 macrophages.

  9. our work shows that ALOX5 plays a moderate anti-tumor role and functions as a drug sensitizer, with a therapeutic potential, in MLL-rearranged AML.

  10. Study shows that higher COX-2 and ALOX5 expression in colorectal cancer (CRC) tissues was correlated with poorer prognosis in patients with CRC. Also, MiR-216a-3p was shown to directly bind to there 3'-UTR and inversely regulates their protein levels modulating CRC cell proliferation.

  11. Indicate a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis.

  12. Our data reveal that 5-LO, which is required for leukotriene production and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dependent recognition of apoptotic cancer cells.

  13. the influence of TGFbeta/SMADs on MLL- and MLL-AF4-mediated 5-LO promoter activation

  14. The knockdown of arachidonate 5-lipoxygenase (Alox5) gene can induce the decreased levels of bcl/abl mRNA and BCR/ABL fusion protein in the K562/ADM cells and increased apoptosis rate.

  15. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.

  16. This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke.

  17. The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment

  18. ROS production induced by the 5-LO pathway mediates the anti-cancer effects of docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine on head and neck squamous cell carcinoma cells.

  19. Specific inhibitors of COX-2 and 5-LOX decreased formation of HKD2 and HKE2 Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved

  20. The observation that the coexpression of FLAP with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP.

Mouse (Murine) Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. that 5-lipoxygenase directly modulates tau phosphorylation at the same epitopes via the cdk5 kinase pathway

  2. Data show that the 5-Lipoxygenase knockout mice (5-LO(-/-) wounds had diminished mRNA expression in the skin lesions.

  3. Within the endothelial population, cells that transition from haemogenic endothelial to erythro-myeloid progenitors specifically express Alox5 and its co-factor Alox5ap, which control leukotriene production. Functional assays using mouse embryonic stem cells demonstrate that leukotrienes promote haematopoietic progenitor cell generation.

  4. neuronal 5LO is directly involved in tau phosphorylation and tau neuropathology.

  5. it was suggested that 5-LO in monocytes played a pivotal role in monocyte-macrophage differentiation and subsequent infiltration of macrophage in neointima, leading to vascular remodeling after vascular injury.

  6. the up-regulation of the ALOX5 is responsible for the Homocysteine-dependent worsening of the Alzheimer's disease phenotype in a relevant mouse model of the disease.

  7. Our data showed that besides the high parasite burden and lack of microbicidal molecules, an imbalance with high COX-2 and 5-LOX eicosanoid expression and a lack of regulatory PPAR-gamma cytoplasm-to-nucleus translocation in macrophages were observed in mice that develop cerebral malaria.

  8. Data indicate that 5-lipoxygenase (5-LO)/leukotriene B4 (LTB4) axis orchestrates graft-versus-host disease (GVHD) development and suggest it could be a target for the development of therapeutic strategies for GVHD treatment.

  9. Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.

  10. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL

  11. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera

  12. Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.

  13. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  14. Data suggest that miR-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6) or TNFa (tumor necrosis factor-alpha).

  15. Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.

  16. GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.

  17. SHH-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 modulate Dectin-1-induced inflammatory cytokines.

  18. involvement of lipoxygenase pathways in TNF-alpha-induced production of cytokines and chemokines

  19. explored the relationship between 5-LO and central and peripheral eosinophilia in an asthma model using PAS or BALB/c mice and 5-LO-deficient mutants

  20. ALOX5 deficiency prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

Horse (Equine) Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. [5-lipoxygenase; 5-lox] protein expression and enzyme activity of 5-LOX were significantly higher in horses harbouring encysted larvae in comparison with horses free of encysted larvae

  2. Increased PGE2 production led to reduction in 5-LO products in LPS-treated equine whole blood via IL-1b.

ALOX5 Protein Profile

Protein Summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ALOX5

  • arachidonate 5-lipoxygenase (ALOX5)
  • arachidonate 5-lipoxygenase (Alox5)
  • arachidonate 5-lipoxygenase a (alox5a)
  • arachidonate 5-lipoxygenase (AFUA_4G02770)
  • arachidonate 5-lipoxygenase (AOR_1_1362014)
  • Arachidonate 5-lipoxygenase (lox5)
  • 5-LO protein
  • 5-LOX protein
  • 5LO protein
  • 5LPG protein
  • 5LX protein
  • AI850497 protein
  • F730011J02 protein
  • LOG5 protein
  • lox5 protein
  • LOX5A protein
  • si:dkey-194n13.2 protein

Protein level used designations for ALOX5

LOX-5 , arachidonic 5-lipoxygenase alpha-10 isoform , arachidonic 5-lipoxygenase delta-10-13 isoform , arachidonic 5-lipoxygenase delta-13 isoform , arachidonic 5-lipoxygenase delta-p10 isoform , arachidonic acid 5-lipoxygenase , leukotriene A4 synthase , 5-lipoxygenase , 5 - Lipoxygenase , 5-LO , LOX2 , arachidonate 5-lipoxygenase , Arachidonate 5-lipoxygenase

240 Homo sapiens
11689 Mus musculus
25290 Rattus norvegicus
404074 Bos taurus
477753 Canis lupus familiaris
567204 Danio rerio
3503886 Aspergillus fumigatus Af293
5994193 Aspergillus oryzae RIB40
100194803 Salmo salar
100718093 Cavia porcellus
423769 Gallus gallus
100156205 Sus scrofa
100341714 Oryctolagus cuniculus
101117390 Ovis aries
101839970 Mesocricetus auratus
100062042 Equus caballus
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