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ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Antibodies (206) and ALOX5 Kits (73) and many more products for this protein.
Showing 10 out of 13 products:
Study shows that higher COX-2 and ALOX5 expression in colorectal cancer (CRC (show CALR Proteins)) tissues was correlated with poorer prognosis in patients with CRC (show CALR Proteins). Also, MiR (show MLXIP Proteins)-216a-3p was shown to directly bind to there 3'-UTR and inversely regulates their protein levels modulating CRC (show CALR Proteins) cell proliferation.
Indicate a potential protective role of ALOX5AP (show ALOX5AP Proteins) and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis.
Our data reveal that 5-LO, which is required for leukotriene production and subsequent T cell recruitment, is downregulated in TAMs through Mer (show MERTK Proteins) tyrosine kinase (show TXK Proteins)-dependent recognition of apoptotic cancer cells.
the influence of TGFbeta (show TGFB1 Proteins)/SMADs on MLL (show MLL Proteins)- and MLL (show MLL Proteins)-AF4-mediated 5-LO promoter activation
The knockdown of arachidonate 5-lipoxygenase (Alox5) gene can induce the decreased levels of bcl/abl (show ABL1 Proteins) mRNA and BCR/ABL (show ABL1 Proteins) fusion protein in the K562/ADM (show ADM Proteins) cells and increased apoptosis rate.
Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.
This study revealed that epistatic interaction among the ALOX5, ALOX5AP (show ALOX5AP Proteins) and MPO (show MPO Proteins) genes played a significant role in vulnerability to ischemic stroke.
The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment
ROS (show ROS1 Proteins) production induced by the 5-LO pathway mediates the anti-cancer effects of docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine on head and neck squamous cell carcinoma cells.
Specific inhibitors of COX-2 and 5-LOX decreased formation of HKD2 and HKE2 (show PFDN6 Proteins) Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved
the up-regulation of the ALOX5 is responsible for the Homocysteine-dependent worsening of the Alzheimer's disease phenotype in a relevant mouse model of the disease.
Our data showed that besides the high parasite burden and lack of microbicidal molecules, an imbalance with high COX-2 and 5-LOX eicosanoid expression and a lack of regulatory PPAR-gamma (show PPARG Proteins) cytoplasm-to-nucleus translocation in macrophages were observed in mice that develop cerebral malaria.
Data indicate that 5-lipoxygenase (5-LO)/leukotriene B4 (LTB4 (show PTGR1 Proteins)) axis orchestrates graft-versus-host disease (GVHD) development and suggest it could be a target for the development of therapeutic strategies for GVHD treatment.
Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.
This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera (show IGF2BP3 Proteins)
Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.
Data suggest that miR (show MLXIP Proteins)-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR (show MLXIP Proteins)-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6 (show IL6 Proteins)) or TNFa (tumor necrosis factor-alpha (show TNF Proteins)).
Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.
[5-lipoxygenase; 5-lox] protein expression and enzyme activity of 5-LOX were significantly higher in horses harbouring encysted larvae in comparison with horses free of encysted larvae
Increased PGE2 production led to reduction in 5-LO products in LPS (show IRF6 Proteins)-treated equine whole blood via IL-1b (show IL1B Proteins).
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, arachidonic 5-lipoxygenase alpha-10 isoform
, arachidonic 5-lipoxygenase delta-10-13 isoform
, arachidonic 5-lipoxygenase delta-13 isoform
, arachidonic 5-lipoxygenase delta-p10 isoform
, arachidonic acid 5-lipoxygenase
, leukotriene A4 synthase
, 5 - Lipoxygenase
, arachidonate 5-lipoxygenase
, Arachidonate 5-lipoxygenase