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ALOX5 Products

(Arachidonate 5-Lipoxygenase (ALOX5))

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This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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Featured ALOX5 Categories

ALOX5 Antibodies

High quality antibodies with extensive validation data.

ALOX5 ELISA Kits

Reliable ELISA kits for a wide range of species.

ALOX5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ALOX5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC, WB
Validations
  • (5)
Cat. No. ABIN3023073
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (5)
Cat. No. ABIN3043727
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (5)
Cat. No. ABIN513267
Quantity 100 μg
Datasheet Datasheet

Recommended ALOX5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6953906
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964994
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964995
Quantity 96 tests
Datasheet Datasheet

Recommended ALOX5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134231
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3083075
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1344921
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our ALOX5 products

Kapral, Wawszczyk, Sośnicki, Jesse, Węglarz: "Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells." in: Prostaglandins & other lipid mediators, Vol. 131, pp. 41-48, (2018) (PubMed).

Kojo, Ito, Eshima, Nishizawa, Ohkubo, Yokomizo, Shimizu, Watanabe, Majima: "BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils." in: Scientific reports, Vol. 6, pp. 29650, (2016) (PubMed).

van der Laan, Foroughi Asl, van den Borne, van Setten, van der Perk, van de Weg, Schoneveld, de Kleijn, Michoel, Björkegren, den Ruijter, Asselbergs, de Bakker, Pasterkamp: "Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study." in: Atherosclerosis, Vol. 239, Issue 2, pp. 528-38, (2015) (PubMed).

Liang, Shi, Luo, Yang: "The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats." in: Behavioral and brain functions : BBF, Vol. 11, pp. 18, (2015) (PubMed).

Al-Sayed, El-Naga: "Protective role of ellagitannins from Eucalyptus citriodora against ethanol-induced gastric ulcer in rats: impact on oxidative stress, inflammation and calcitonin-gene related peptide." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 22, Issue 1, pp. 5-15, (2015) (PubMed).

Wang, Wang, Gao, Qu: "The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice." in: Drug discoveries & therapeutics, Vol. 8, Issue 1, pp. 25-32, (2014) (PubMed).

Lin, Lin, Wu, Chiu, Tang, Hour, Liou, Tu, Yang, Fu: "5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts." in: PLoS ONE, Vol. 9, Issue 9, pp. e107890, (2014) (PubMed).

Mancini, Ortiz, Croxatto, Gallo: "Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet." in: BMC ophthalmology, Vol. 13, Issue 1, pp. 14, (2013) (PubMed).

Ohkubo, Ito, Minamino, Mishima, Hirata, Hosono, Shibuya, Yokomizo, Shimizu, Watanabe, Majima: "Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 8, pp. 3132-43, (2013) (PubMed).

Kalayci, Birben, Sackesen, Keskin, Tahan, Wechsler, Civelek, Soyer, Adalioglu, Tuncer, Israel, Lilly: "ALOX5 promoter genotype, asthma severity and LTC production by eosinophils." in: Allergy, Vol. 61, Issue 1, pp. 97-103, (2005) (PubMed).

Synonyms and alternative names related to ALOX5

arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase (Alox5), arachidonate 5-lipoxygenase a (alox5a), arachidonate 5-lipoxygenase (AFUA_4G02770), arachidonate 5-lipoxygenase (AOR_1_1362014), Arachidonate 5-lipoxygenase (lox5), 5-LO, 5-LOX, 5LO, 5LPG, 5LX, AI850497, F730011J02, LOG5, lox5, LOX5A, si:dkey-194n13.2

Protein level used designations for ALOX5

  • LOX-5
  • arachidonic 5-lipoxygenase alpha-10 isoform
  • arachidonic 5-lipoxygenase delta-10-13 isoform
  • arachidonic 5-lipoxygenase delta-13 isoform
  • arachidonic 5-lipoxygenase delta-p10 isoform
  • arachidonic acid 5-lipoxygenase
  • leukotriene A4 synthase
  • 5-lipoxygenase
  • 5 - Lipoxygenase
  • 5-LO
  • LOX2
  • arachidonate 5-lipoxygenase
  • Arachidonate 5-lipoxygenase
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