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Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Additionally we are shipping ASTL Antibodies (12) and ASTL Proteins (3) and many more products for this protein.
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The SAS1B metalloproteinase is proposed as a prototype cancer-oocyte tumor surface neoantigen for development of targeted immunotherapeutics with limited on-target/off tumor effects predicted to be restricted to the population of growing oocytes.
SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition.
cloning and characterization; could play in mammals a physiological function similar to that performed by hatching proteases in evolutionary distant species from arthropods to fish
Intracellular activation of Astl mediates pre-fertilization hardening of the zona pellucida.
Seven amino acid motif near Astl N-terminus is necessary and sufficient for cortical granule localization.
ASTL is dynamically expressed in the embryonic epithelium and in embryonic stem cells, suggesting an important function for the control of epithelial cell behavior during early development.
Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in the postfertilization block to sperm binding that ensures monospermic fertilization and successful development
Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity.
cloning and characterization of ovastacin; could play in mammals a physiological function similar to that performed by hatching proteases in evolutionary distant species from arthropods to fish [ovastacin]
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).
, astacin-like metalloendopeptidase (M12 family)
, oocyte astacin
, sperm acrosomal SLLP1
, sperm acrosomal SLLP1-binding protein