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This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Additionally we are shipping ATOH7 Proteins (6) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal ATOH7 Primary Antibody for WB - ABIN531345
Prasov, Brown, Glaser: A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina. in PLoS ONE 2010
Show all 2 Pubmed References
Human Monoclonal ATOH7 Primary Antibody for ELISA, WB - ABIN531346
Prasov, Masud, Khaliq, Mehdi, Abid, Oliver, Silva, Lewanda, Brodsky, Borchert, Kelberman, Sowden, Dattani, Glaser: ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. in Human molecular genetics 2012
Cow (Bovine) Polyclonal ATOH7 Primary Antibody for WB - ABIN2775072
McLellan, Langlands, Kealey: Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. in Mechanisms of development 2003
Human Polyclonal ATOH7 Primary Antibody for ELISA - ABIN451594
Brown, Dagenais, Chen, Glaser: Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. in Mammalian genome : official journal of the International Mammalian Genome Society 2002
Zebrafish (Danio rerio) Polyclonal ATOH7 Primary Antibody for ELISA - ABIN451523
Kay, Link, Baier: Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. in Development (Cambridge, England) 2005
Human Polyclonal ATOH7 Primary Antibody for ICC, IF - ABIN4282208
Miesfeld, Glaser, Brown: The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody. in Gene expression patterns : GEP 1970
Atoh7 indirectly impacts amacrine-cell division modes to regulate the right number of Barhl2 (show BARHL2 Antibodies)-expressing cells. Atoh7 itself influences the subtypes of Barhl2 (show BARHL2 Antibodies)-dependent amacrine cells.
Observations suggest that Irx2 (show IRX2 Antibodies) functions downstream of irx1a (show IRX1 Antibodies) to control shh (show SHH Antibodies) expression in the retina. Study proposed a novel transcriptional cascade of ath5-irx1a (show IRX1 Antibodies)-irx2a in the regulation of hedgehog (show SHH Antibodies) waves during vertebrate retinal development.
Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina.
The transient features of Atoh7 protein expression during retinal neurogenesis match the expected pattern at the tissue and cellular level.
Pou4f2 (show POU4F2 Antibodies) and Isl1 (show ISL1 Antibodies), are sufficient to specify the retinal ganglion cell fate in ATOH7 deficient mice
This study present evidence for a Pax6 (show PAX6 Antibodies)-Atoh7-Eya2 (show EYA2 Antibodies) pathway that acts downstream of Atoh7 but upstream of differentiation factor Pou4f2 (show POU4F2 Antibodies).
Notch (show NOTCH1 Antibodies) signaling controls the overall tempo of retinogenesis through Atoh7 and Neurog2 (show NEUROG2 Antibodies), by integrating cell fate specification, the wave of neurogenesis and the developmental status of cells ahead of this wave
The level of basic helix-loop-helix factor Math5 expression may determine the ultimate number of retinal ganglion cells.
Atoh7 acts dominantly in Neurod1-expressing retina progenitor cells to activate the retinal ganglion cell genetic program.
Results suggest that Math5 is not sufficient to stimulate retinal ganglion cell (RGC)fate.
new insights into Math5 function, ganglion cell development, and the mechanism of retinal fate determination were provided.
The present data demonstrates that the loss of ganglion cells in the Math5(-/-) mice is associated with a lack of retinal vascular development.
Report Math5 expression/function in retinal ganglion cells.
In conclusion, we have identified a homozygous mutation in the ATOH7 gene in a patient with nonsyndromic congenital retinal nonattachment.
We evaluated 21 consanguineous NCRNA pedigrees and identified the causal mutations in known retinal genes in 13 out of our 21 families. We found mutations in ATOH7 in three families.
We discovered a novel SNP, rs56238729 (P = 1.22 x 10-13), in the ATOH7-PBLD region that is significantly associated with VCDR in Latino individuals.
The genotype and allele frequencies of the polymorphism in ATOH7 did not show any statistically significant association with primary open angle glaucomacompared to controls.
Familial linkage studies for primary angle-closure glaucoma have been performed and identified ATOH7 causative primary angle-closure glaucoma disease
Single nucleotide polymorphism in ATOH7 gene is associated with primary open angle glaucoma.
The significant association of three common variants in TMCO1 (show TMCO1 Antibodies), ATOH7, and CAV1 (show CAV1 Antibodies) with primary open angle, primary angle closure, and pseudoexfoliation glaucoma was found in Pakistani cohorts.
Mutations within the ATOH7 gene are not implicated in the pathogenesis of optic nerve hypoplasia in our patient cohort.
This study finds that ATOH7 is associated with optic disc size but not independently with cup/disk ratio.
a bHLH mutation in ATOH7 causes recessive persistent hyperplasia of the primary vitreous
This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment.
atonal homolog 7
, atonal homolog 7 (Drosophila)
, atonal homolog 5
, helix-loop-helix protein zATH-5
, protein atonal homolog 5
, protein atonal homolog 7
, protein lakritz
, helix-loop-helix protein mATH-5
, class A basic helix-loop-helix protein 13
, helix-loop-helix protein hATH-5
, Atonal Homolog 5
, atonal transcription factor homologue
, helix-loop-helix protein cATH-5