anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) Antibodies

The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Additionally we are shipping BAP1 Proteins (6) and BAP1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BAP1 8314 Q92560
BAP1 306257 D3ZHS6
BAP1 104416 Q99PU7
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Top anti-BAP1 Antibodies at antibodies-online.com

Showing 10 out of 153 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of BAP1 Antibody (N-term) (ABIN388948) in mouse testis lysates (35 µg/lane). BAP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB The anti-BAP1 Pab (ABIN388949) is used in Western blot to detect BAP1 in SK-BR-3 cell lysate. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated WB Anti-BAP1 antibody (monoclonal), Western blotting Lane: MCF-7 Cell Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated FACS, WB Detection of BAP1 in HeLa WCE using ABIN258775 (2ug/ml). Flow Cytometry: BAP1 Antibody (1G8) [ABIN2587751] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HEK-293 (B) cells using BAP1 antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Rabbit Un-conjugated IHC, WB ABIN6267095 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HeLa cells treated with UV, using Phospho-BAP1 (Ser592) Antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts of Rat ovarian tissue sample,using Phospho-BAP1 (Ser369) Antibody(ABIN6270263). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated ICC, WB 100 μg Log in to see 11 to 14 Days
$449.17
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of BAP1 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of BAP1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL Log in to see 13 to 14 Days
$487.50
Details

Top referenced anti-BAP1 Antibodies

  1. Human Monoclonal BAP1 Primary Antibody for FACS, WB - ABIN258775 : Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010 (PubMed)

  2. Human Polyclonal BAP1 Primary Antibody for IHC (p), WB - ABIN388948 : Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011 (PubMed)

More Antibodies against BAP1 Interaction Partners

Human BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. In intrahepatic cholangiocarcinoma retained expression of BAP-1 and PBRM-1, and an overexpression of S100P are related to a poor prognosis.

  2. Loss of BAP1 expression due to BAP1 Mutation is associated with tumorigenesis.

  3. Results confirm the high frequency of BAP1 alterations in ICC and low frequency in pancreatic cancers. It also suggests that BAP1 is commonly altered in a subtype of HCC with both hepatocytic and biliary differentiation.

  4. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukemogenesis.

  5. Studied prevalence of BAP1 germline variants in patients with mesothelioma in regards to cumulative asbestos exposure.

  6. This study of patients with ccRCC, pooled analysis and multivariable modeling demonstrated that three recurrently mutated genes, BAP1, SETD2, and TP53, have statistically significant associations with poor clinical outcomes.important clinical confounders, mutations of TP53 and SETD2 were associated with decreased CSS and RFS, respectively.

  7. Low PAB1 expression is associated with early stages of clear cell renal cell carcinoma.

  8. Study based on 47 tissue samples from spitzoid tumors revealed 2 BAP1-inactived cases. The absence of anomalous expression of translocation-related proteins ALK and ROS1 in this series, composed predominantly of low-grade/low-risk tumors, indicates that translocated spitzoid lesions may not be as prevalent as initially suggested, at least in some populations.

  9. BAP1 loss differentiates malignant pleural mesothelioma from metastatic pleural tumours

  10. germline null mutations in BAP1 have a significantly higher frequency in cancer patients than the general population. Given the low frequency of reported families with BAP1-tumor predisposition syndrome (BAP1-TPDS), our results suggest that the syndrome is underreported especially in patients with cancer

  11. Multivariate analysis showed that the presence of monosomy 3, 8q gain, and loss of BAP1 protein were significantly associated to DPFS, while BAP1 gene mutation was not, mainly due to the presence of metastatic UM cases with negative BAP1 IHC and no BAP1 mutation detected by Sanger sequencing.

  12. Time to metastasis differs in patients with primary uveal melanoma with different grades of nuclear BAP1 immunoreactivity. Nuclear BAP1 stain is the only significant independent predictor of metastatic disease in this study. Our data support the role of BAP1 immunohistochemical staining of primary uveal melanoma to evaluate metastatic risk

  13. Studies have clarified novel important molecular aspects associated with the cancer predisposition of BAP1+/- carrying individuals and suggest new relevant questions, related to BAP1-dependent cancer susceptibility, and to more general gene/environment interactions.

  14. The authors demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism.

  15. Case Report: germline BAP1 mutation associated with melanoma of foot.

  16. Tissue-specific prognostic and clinicopathological significance of BAP1 expression (meta-analysis).

  17. these results highlight an important role of miR-31 functioning as an oncomir which could promote EMT in cervical cancer via downregulating BAP1 expression. Thus, downregulation of miR-31 could be a novel approach for the molecular treatment of cervical cancers and other malignancies.

  18. A cancer surveillance program for individuals who carry germline BAP1 mutations may help identify tumors such as uveal melanoma, cutaneous melanoma, and renal cell carcinoma at early and treatable stages

  19. Germline BAP1 mutations induce a Warburg effect

  20. Our comparative thermodynamic analysis reveals that BAP1-ubiquitin interaction is majorly driven by entropy factor which is unique amongst UCHs. Our study sheds light on BAP1 interaction with ubiquitin, which will be useful in understanding its enzymatic function.

Mouse (Murine) BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. Findings indicate a function for BRCA1-associated protein-1 (BAP1) in maintaining the lymphoid lineage.

  2. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukemogenesis.

  3. We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (ccRCC)origins

  4. our results establish a previously unappreciated role of BAP1 in modulating the cellular adaptability to metabolic stress and uncover a pivotal function of BAP1 in the regulation of the ER stress gene-regulatory network.

  5. dual inactivation of Vhl with either Bap1 or Pbrm1 results in faithful genetically engineered murine models of clear cell renal cell carcinoma (ccRCC).

  6. Bap1 as a metabolic regulator in liver and pancreas.

  7. BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.

  8. Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.

  9. INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells

  10. Both Vhl and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl in the kidney.

  11. Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.

  12. results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 and OGT that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm

  13. Bap1 helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition

BAP1 Antigen Profile

Protein Summary

The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.

Gene names and symbols associated with BAP1

  • BRCA1 associated protein 1 (BAP1) antibody
  • Brca1 associated protein 1 (Bap1) antibody
  • BRCA1 associated protein 1 L homeolog (bap1.L) antibody
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (bap1) antibody
  • BRCA1 associated protein 1 (Bap1) antibody
  • 2300006C11Rik antibody
  • AA989761 antibody
  • AW553466 antibody
  • BAIAP3 antibody
  • hucep-6 antibody
  • hucep-13 antibody
  • mKIAA0272 antibody
  • si:dkey-42i9.9 antibody
  • uch-x4 antibody
  • uchl2 antibody

Protein level used designations for BAP1

cerebral protein 6 , cerebral protein-13 , ubiquitin carboxyl-terminal hydrolase BAP1 , BAI1-associated protein 3 , BRCA1-associated protein 1 , ubiquitin carboxy-terminal hydrolase , Brca1 associated protein 1 , ubiquitin C-terminal hydrolase X4 , BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

GENE ID SPECIES
8314 Homo sapiens
100124510 Bos taurus
306257 Rattus norvegicus
484737 Canis lupus familiaris
104416 Mus musculus
415944 Gallus gallus
734438 Xenopus laevis
558885 Danio rerio
100731081 Cavia porcellus
100051934 Equus caballus
100154798 Sus scrofa
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