anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) Antibodies

The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Additionally we are shipping BAP1 Proteins (6) and BAP1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BAP1 8314 Q92560
BAP1 306257 D3ZHS6
BAP1 104416 Q99PU7
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Top anti-BAP1 Antibodies at antibodies-online.com

Showing 10 out of 156 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB Anti-BAP1 antibody (monoclonal), Western blotting Lane: MCF-7 Cell Lysate 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, WB ABIN6267095 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HeLa cells treated with UV, using Phospho-BAP1 (Ser592) Antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts of Rat ovarian tissue sample,using Phospho-BAP1 (Ser369) Antibody(ABIN6270263). 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated ICC, WB 100 μg 11 to 14 Days
$449.17
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of BAP1 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of BAP1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6271111 at 1/100 staining human Prostate carcinoma tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of Rat ovarian tissue sample,using BAP1 Antibody(ABIN6271111). 100 μL 11 to 12 Days
$450.00
Details
Human Mouse Un-conjugated IF, WB 0.1 mg 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details

Top referenced anti-BAP1 Antibodies

  1. Human Monoclonal BAP1 Primary Antibody for FACS, WB - ABIN258775 : Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010 (PubMed)

More Antibodies against BAP1 Interaction Partners

Human BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. study uncovers a new mechanism for BAP1 in the regulation of cell apoptosis in neuroblastoma cells.

  2. BAP1 is highly positively correlated with RBM15B and USP19 expression in invasive breast carcinoma, UM, and colon adenocarcinoma

  3. Regarding time to clinically detected metastases, the first 2 peaks appear to be associated with BAP1-mutated tumors and the late peak to SF3B1-mutated tumors. None of the tumors with only an EIF1AX mutation metastasized.

  4. Loss of BAP1 Expression Occurs Rarely to Never in Colorectal Adenocarcinoma.

  5. Combined MTAP and BAP1 IHC is a reliable and effective method for distinguishing sarcomatoid MPM from fibrous pleuritis.

  6. This article is a synthesis of the literature on the functions of the BAP1 gene, the tumour risks related to its alteration and the follow up of patients bearing a constitutional mutation. [review]

  7. BAP1 can induce radioresistance in HNSCC cells, possibly via deubiquitination of H2Aub and modulation of HR, and was associated with poor outcomes in patients with HNSCC

  8. When adequate material is obtained, immunocytology using BAP1 is a potentially informative tool for prognostication of uveal melanoma.

  9. Cutaneous melanomas with loss of BAP1 expression arising in patients without a family history of cancer.

  10. BAP1 haploinsufficiency refines peritoneal mesothelioma classification and predicts response to immunotherapy.

  11. DNA helicases CHD2 and CHD7 could reduce BAP1 promoter activity, likely through unwinding its G4 structures.

  12. BAP1 appears to modulate gene expression by countering H2A ubiquitination, but its loss only promotes tumorigenesis in cells that do not engage an RNF2-dependent apoptotic program.

  13. Suggests that BAP1 loss in well-differentiated papillary mesothelioma may be associated with subsequent development of malignant mesothelioma.

  14. Expression of BAP1 in serous effusions is a highly sensitive and specific marker for malignant mesothelioma.

  15. presence of BAP1 mutations associated significantly with BAP1 protein expression, the incidence of organ metastasis, progression free survival after second line treatment and clinical response after second line treatment only

  16. The results of this study provide new insight into BAP1 status and changes of sensitivity to the DNA damaging agent gemcitabine, widely used in second-line therapy for MMe.

  17. findings showed that genetic mutations are involved in BAP1 down-regulation, leading to promotion of the invasive character of cancer cells and poor prognosis in gallbladder cancer

  18. Data link the tumour suppressor BRCA1-associated protein 1 (BAP1) to metabolism-related biological processes.

  19. The deubiquitinase BRCA1-associated protein-1 (BAP1) is a component of the repressor complex whose activity maintains NCoR1 at sites in the beta-globin locus, and BAP1 inhibition in erythroid cells massively induces gamma-globin synthesis.

  20. Patients with metastatic ccRCC that present loss of BAP1 expression in metastatic tissue demonstrated poor survival rates and represent a relevant risk group for tumor recurrence and death.

Mouse (Murine) BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. Bap1 deletion in melanocytes cooperates with the constitutively active, oncogenic form of BRAF (BRAF(V600E) ) and Ultraviolet rays to cause melanoma in mice.

  2. High BAP1 expression is associated with myeloid malignancy.

  3. BAP1 appears to modulate gene expression by countering H2A ubiquitination, but its loss only promotes tumorigenesis in cells that do not engage an RNF2-dependent apoptotic program.

  4. Findings indicate a function for BRCA1-associated protein-1 (BAP1) in maintaining the lymphoid lineage.

  5. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukemogenesis.

  6. We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (ccRCC)origins

  7. our results establish a previously unappreciated role of BAP1 in modulating the cellular adaptability to metabolic stress and uncover a pivotal function of BAP1 in the regulation of the ER stress gene-regulatory network.

  8. dual inactivation of Vhl with either Bap1 or Pbrm1 results in faithful genetically engineered murine models of clear cell renal cell carcinoma (ccRCC).

  9. Bap1 as a metabolic regulator in liver and pancreas.

  10. BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.

  11. Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.

  12. INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells

  13. Both Vhl and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl in the kidney.

  14. Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.

  15. results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 and OGT that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm

  16. Bap1 helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition

BAP1 Antigen Profile

Protein Summary

The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.

Gene names and symbols associated with BAP1

  • BRCA1 associated protein 1 (BAP1) antibody
  • Brca1 associated protein 1 (Bap1) antibody
  • BRCA1 associated protein 1 L homeolog (bap1.L) antibody
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (bap1) antibody
  • BRCA1 associated protein 1 (Bap1) antibody
  • 2300006C11Rik antibody
  • AA989761 antibody
  • AW553466 antibody
  • BAIAP3 antibody
  • hucep-6 antibody
  • hucep-13 antibody
  • mKIAA0272 antibody
  • si:dkey-42i9.9 antibody
  • uch-x4 antibody
  • uchl2 antibody

Protein level used designations for BAP1

cerebral protein 6 , cerebral protein-13 , ubiquitin carboxyl-terminal hydrolase BAP1 , BAI1-associated protein 3 , BRCA1-associated protein 1 , ubiquitin carboxy-terminal hydrolase , Brca1 associated protein 1 , ubiquitin C-terminal hydrolase X4 , BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

GENE ID SPECIES
8314 Homo sapiens
100124510 Bos taurus
306257 Rattus norvegicus
484737 Canis lupus familiaris
104416 Mus musculus
415944 Gallus gallus
734438 Xenopus laevis
558885 Danio rerio
100731081 Cavia porcellus
100051934 Equus caballus
100154798 Sus scrofa
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