BAP1 antibody (AA 460-729)

Catalog No. ABIN6137447

This Rabbit Polyclonal antibody specifically detects BAP1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for BAP1 antibody (AA 460-729) (ABIN6137447)

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-BAP1 Antibody

Binding Specificity: AA 460-729

Sequence: SIPLSIKTSS GAGSPAVAVP THSQPSPTPS NESTDTASEI GSAFNSPLRS PIRSANPTRP SSPVTSHISK VLFGEDDSLL RVDCIRYNRA VRDLGPVIST GLLHLAEDGV LSPLALTEGG KGSSPSIRPI QGSQGSSSPV EKEVVEATDS REKTGMVRPG EPLSGEKYSP KELLALLKCV EAEIANYEAC LKEEVEKRKK FKIDDQRRTH NYDEFICTFI SMLAQEGMLA NLVEQNISVR RRQGVSIGRL HKQRKPDRRK RSRPYKAKRQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 460-729 of human BAP1 (NP_004647.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Alternative Name: BAP1

Background: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.,BAP1,HUCEP-13,UCHL2,hucep-6,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Ubiquitin,BAP1

Molecular Weight: 80 kDa

Gene ID: 8314

UniProt: Q92560