BAP1 antibody (AA 191-326)

Catalog No. ABIN6940957

This Mouse Monoclonal antibody specifically detects BAP1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for BAP1 antibody (AA 191-326) (ABIN6940957)

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAP1 antibody is un-conjugated

Application: ELISA

Clone: BAP1-2431

Product Details anti-BAP1 Antibody

Binding Specificity: AA 191-326

Purpose: BAP1 (BRCA1 Associated Protein 1) Antibody

Specificity: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary)

Isotype: IgG2c, kappa

Application Details

Application Notes:

Positive Control: Jurkat or PC-3 or HepG2 cells. Testis, Placenta, Ovarian or Breast Carcinoma.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Alternative Name: BAP1

Background:

BAP1, BRCA1 associated protein 1, Cerebral protein 13, Cerebral protein 6, HUCEP 13, Hucep 6, HUCEP13, Hucep6, TPDS, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl terminal hydrolase BAP1, UCHL2

Jurkat or PC-3 or HepG2 cells. Testis, Ovarian or Breast Carcinoma., Placenta

Molecular Weight: 91kDa

Gene ID: 8314, 106674

UniProt: Q92560