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BPTF was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Additionally we are shipping and many more products for this protein.
Showing 10 out of 40 products:
Human Monoclonal BPTF Primary Antibody for ELISA, WB - ABIN968990
Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. in PLoS genetics 2008
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Human Monoclonal BPTF Primary Antibody for ELISA, WB - ABIN965692
Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. in The Journal of biological chemistry 2009
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Human Polyclonal BPTF Primary Antibody for ICC, IF - ABIN188587
Goldman, Garlick, Kingston: Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z. in The Journal of biological chemistry 2010
High BPTF expression in glioma tissue specimens was significantly associated with WHO grade and tumor size. Survival analysis revealed that the BPTF highexpression group had poorer overall and progressionfree survival compared with the lowexpression group.
Haploinsufficiency of BPTF gene is associated with Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.
Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases
NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, Fetal ALZ50-reactive clone 1 (FAC1).
Overexpression of BPTF is associated with melanoma cell survival and progression.
somatic frameshift mutations of BPTF were present in gastric cancer and colorectal cancers
BPTF plays an essential role in cell growth and survival by targeting multiply signaling pathways in human lung cancers
High BPTF expression was significantly correlated with tumor progression and may be a potent prognostic marker of colorectal cancer.
expression may be marker for survival prediction in hepatocellular carcinoma
The PHD-adjacent bromodomain in BPTF binds with marked selectivity H4K16ac, in combination with H3K4me3 at the mononucleosome level.
the novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype
hkelch-like ECH-associated protein 1 regulates FAC1 in addition to its known role in control of Nrf2
These findings suggest a role for FAC1 in apoptosis following release of Nrf2 from Keap1 in response to oxidative stress.
crystallographic and NMR structures of the bromodomain-proximal PHD finger of BPTF in free and H3(1-15)K4me3-bound states
High FALZ expression is associated with metastatic spread to the brain in primary non-small cell lung cancer.
This study implicates BPTF in maintaining the unique epigenetic state of mammary gland stem cells.
enhanced activity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.
These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.
We find that the melanocyte stem cells from these animals are abnormal and that once they are stimulated at anagen, Bptf is required to ensure the expression of melanocyte markers and their differentiation into mature adult melanocytes.
NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
Results suggest that BPTF/FAC1 is essential in the extraembryonic lineage for correct development of the ectoplacental cone and fetomaternal interactions.
study concludes that Bptf likely regulates genes and signaling pathways essential for the development of key tissues of the early mouse embryo
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.
bromodomain and PHD domain transcription factor
, bromodomain and PHD finger-containing transcription factor
, fetal Alz-50 clone 1 protein
, fetal Alz-50 reactive clone 1
, fetal Alzheimer antigen
, nucleosome remodeling factor, large subunit
, nucleosome-remodeling factor subunit BPTF
, fetal alzheimer antigen, falz
, bromodomain PHD finger transcription factor
, nucleosome-remodeling factor subunit BPTF-like