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BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Antibodies (188) and BUB1B Kits (1) and many more products for this protein.
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Authors show that two distinct pools of BubR1/Bub3 (show BUB3 Proteins) exist at kinetochores and we uncouple these with defined BubR1/Bub3 (show BUB3 Proteins) mutants to address their function.
Small sequence differences in Bub1 (show BUB1 Proteins) and BubR1 direct Bub3 (show BUB3 Proteins) to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.
we found that FOXM1 (show FOXM1 Proteins) inhibitor attenuated tumorigenesis and radioresistance of glioblastoma (GBM) both in vitro and in vivo. Altogether, BUB1B promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B could be a potential therapeutic target for GBM.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (show CDC20 Proteins)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (show MYO5A Proteins) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (show PPP2R4 Proteins) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (show PPP2R4 Proteins) to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
BubR1 insufficiency impairs angiogenesis and results in limb loss in ischemic hind limbs.
Up-regulation of desmocollin-1 (DSC1 (show DSC1 Proteins)) was observed in wild-type, but not Low-budding uninhibited by benzimidazole-related 1(BubR1)-expressing mutant (BubR1(L/L)) mice after partial hepatectomy (PHx).
The combination of budding uninhibited by benzimidazole-related 1 (BUBR1) insufficiency and administration of KBrO3 worsens the proliferative capacity compared with the impaired proliferation induced by BUBR1 insufficiency alone.
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (show EZH2 Proteins) directly interacted with and stabilized BubR1, an effect driving EZH2 (show EZH2 Proteins) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Proteins), and Ercc1 (show ERCC1 Proteins)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (show ERCC1 Proteins)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (show SGOL1 Proteins) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Together, our findings demonstrate that Bub1 (show BUB1 Proteins) acts at multiple points to assure the correct kinetochore formation.
Our data implicate a previously unknown function of Bub1 that can be hijacked by pathogens to facilitate their entry, and Bub1 may serve as a potential antiviral therapy target for limiting viral entry.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
MAD3/BUB1-related protein kinase
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint kinase MAD3L
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog, beta
, BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like