Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) Proteins (BUB1B)

BUB1B encodes a kinase involved in spindle checkpoint function. Additionally we are shipping BUB1B Antibodies (182) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BUB1B 701 O60566
BUB1B 12236 Q9Z1S0
Rat BUB1B BUB1B 171576  
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Top BUB1B Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
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Insect Cells Human GST tag 5 μg 11 to 12 Days
$516.00
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Insect Cells Human GST tag   10 μg 3 to 4 Days
$310.00
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BUB1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) Interaction Partners

Human Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. our data resolve some long-standing questions about the interplay between BUB1 and BUBR1 and their respective roles in the spindle assembly checkpoint and chromosome alignment.

  2. CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases

  3. Human gastric cancer tissues with low BUBR1 expression showed no eNOS expression. A decrease in BUBR1 reduced eNOS bioavailability through a pathway other than eNOS phosphorylation.

  4. Finally, the authors show that the kinetochore localization of BUB1 and BUBR1 decreases with the age of the oocyte donors. This could contribute to oocyte aneuploidy.

  5. Authors show that two distinct pools of BubR1/Bub3 exist at kinetochores and we uncouple these with defined BubR1/Bub3 mutants to address their function.

  6. Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.

  7. we found that FOXM1 inhibitor attenuated tumorigenesis and radioresistance of glioblastoma (GBM) both in vitro and in vivo. Altogether, BUB1B promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B could be a potential therapeutic target for GBM.

  8. Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.

  9. Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

  10. BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.

  11. Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.

  12. Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors

  13. structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets.

  14. Overexpression of BUB1B is associated with Invasive Breast Cancer.

  15. we showed that BubR1 and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.

  16. The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential.

  17. We show that kinetochore recruitment of BUBR1 and BUB3 by BUB1 is dispensable for SAC activation

  18. Data suggest that both BubR1 and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.

  19. BubR1 knockdown significantly decreased cellular invasion but slightly affect cellular proliferation on both Ca9-22 and Cal-27 cells.

  20. BubR1 contributes to preventing premature aging. [review]

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. that Sirt2-dependent BubR1 deacetylation involves in the regulation of meiotic apparatus in normal oocytes and mediates the effects of advanced maternal age on oocyte quality

  2. BubR1 insufficiency impairs angiogenesis and results in limb loss in ischemic hind limbs.

  3. Up-regulation of desmocollin-1 (DSC1) was observed in wild-type, but not Low-budding uninhibited by benzimidazole-related 1(BubR1)-expressing mutant (BubR1(L/L)) mice after partial hepatectomy (PHx).

  4. The combination of budding uninhibited by benzimidazole-related 1 (BUBR1) insufficiency and administration of KBrO3 worsens the proliferative capacity compared with the impaired proliferation induced by BUBR1 insufficiency alone.

  5. Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

  6. Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.

  7. EZH2 directly interacted with and stabilized BubR1, an effect driving EZH2 into the concert of meiosis regulation.

  8. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

  9. Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.

  10. These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.

  11. BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.

  12. Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.

  13. the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP.

  14. BubR1 insufficiency elicits an aging response that is counteracted by p53 and involves single or multiple p53 targets, depending on the tissue type.

  15. BubR1 acetylation is essential for embryonic development.

  16. these data demonstrate that the BUBR1 GTTA mutation compromises longevity and healthspan, raising the interesting possibility that mono-allelic changes in BUBR1 might contribute to differences in aging rates in the general population.

  17. Hhigh-level expression of BubR1 extends lifespan and delays age-related deterioration and aneuploidy in several tissues.

  18. BubR1 is a spindle assembly checkpoint protein regulating meiotic progression of oocytes.

  19. BUBR1 is essential for early embryonic development and normal hematopoiesis

  20. mutations of Bub1 and BubR1 found in Brca2- mutant mice indeed are responsible for the chromosome instability in Brca2-mutated tumors.

Xenopus laevis Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. Together, our findings demonstrate that Bub1 acts at multiple points to assure the correct kinetochore formation.

Fruit Fly (Drosophila melanogaster) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. Our data implicate a previously unknown function of Bub1 that can be hijacked by pathogens to facilitate their entry, and Bub1 may serve as a potential antiviral therapy target for limiting viral entry.

BUB1B Protein Profile

Protein Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Gene names and symbols associated with BUB1B

  • BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B)
  • BUB1B, mitotic checkpoint serine/threonine kinase (Bub1b)
  • BUB1 mitotic checkpoint serine/threonine kinase B (Bub1b)
  • BUB1B, mitotic checkpoint serine/threonine kinase L homeolog (bub1b.L)
  • BUB1B, mitotic checkpoint serine/threonine kinase (bub1b)
  • Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (bub1b)
  • Bub1 kinase (Bub1)
  • AU045529 protein
  • bub1 protein
  • BUB1-like protein
  • Bub1A protein
  • bub1b protein
  • BUB1beta protein
  • BubR1 protein
  • BubRI protein
  • CG14030 protein
  • CG14030/Bub1 protein
  • Dmel\\CG14030 protein
  • hBUBR1 protein
  • MAD3L protein
  • MVA1 protein
  • SSK1 protein

Protein level used designations for BUB1B

MAD3/BUB1-related protein kinase , budding uninhibited by benzimidazoles 1 homolog beta , mitotic checkpoint kinase MAD3L , mitotic checkpoint serine/threonine-protein kinase BUB1 beta , budding uninhibited by benzimidazoles 1 beta , budding uninhibited by benzimidazoles 1 homolog, beta , BUB1 budding uninhibited by benzimidazoles 1 homolog beta , budding uninhibited by benzimidazoles 1 homolog beta (yeast) , mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like , Bub1-PA , CG14030-PA

GENE ID SPECIES
701 Homo sapiens
12236 Mus musculus
171576 Rattus norvegicus
378923 Xenopus laevis
453324 Pan troglodytes
537027 Bos taurus
608350 Canis lupus familiaris
100125106 Xenopus (Silurana) tropicalis
100196482 Salmo salar
100413586 Callithrix jacchus
100423079 Macaca mulatta
100455824 Pongo abelii
100464546 Ailuropoda melanoleuca
33758 Drosophila melanogaster
378922 Gallus gallus
100607252 Nomascus leucogenys
100629735 Equus caballus
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