anti-C-Type Lectin Domain Family 4, Member D (CLEC4D) Antibodies

CLEC4D encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC4D Proteins (10) and CLEC4D Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC4D 338339 Q8WXI8
CLEC4D 17474 Q9Z2H6
CLEC4D 362432 Q69FH1
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-CLEC4D Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of 293T , using CLEC4D antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277316 at 1/100 staining Human Head and neck cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, WB 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB Western blot analysis in T47D cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using CLEC4D antibody (ABIN5971447) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details
Human Mouse PE FACS   100 Tests 11 to 14 Days
$1,013.83
Details
Human Mouse APC FACS   100 Tests 11 to 14 Days
$1,101.83
Details
Human Rabbit Un-conjugated ELISA   100 μL 14 to 16 Days
$312.53
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human oral mucosa with CLEC4D polyclonal antibody  shows strong cytoplasmic positivity in squamous epithelial cells. Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with CLEC4D polyclonal antibody . 100 μL 11 to 12 Days
$637.32
Details

Top referenced anti-CLEC4D Antibodies

  1. Human Monoclonal CLEC4D Primary Antibody for CyTOF, FACS - ABIN4900404 : Graham, Gupta, Schafer, Reid, Kimberg, Dennehy, Hornsell, Guler, Campanero-Rhodes, Palma, Feizi, Kim, Sobieszczuk, Willment, Brown: The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. in The Journal of biological chemistry 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal CLEC4D Primary Antibody for FACS - ABIN4897647 : Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. in Journal of leukocyte biology 2017 (PubMed)

More Antibodies against CLEC4D Interaction Partners

Human C-Type Lectin Domain Family 4, Member D (CLEC4D) interaction partners

  1. The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells.

  2. Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants.

  3. CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule

  4. Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor.

Mouse (Murine) C-Type Lectin Domain Family 4, Member D (CLEC4D) interaction partners

  1. MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficient mice with E. coli-induced sepsis showed lower survival rates and reduced bacterial clearance when compared with control mice, despite similar levels of proinflammatory cytokine production.

  2. Dectin-3 deficiency did not lead to increased susceptibility of mice to experimental pulmonary C. neoformans infection. Also, no significant differences in pulmonary leukocyte recruitment and cytokine production were observed in Dectin-3 deficient mice compared to wild type infected mice

  3. activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk-dependent manner.

  4. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL (Clecsf8, Clec4d). Conversely, they show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  5. Data show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production.

  6. MCL regulates the development of vaccine-induced Th17 cells and protective immunity against lethal experimental infection with Blastomyces dermatitidis.

  7. major contributor to activation of innate immunity against M. bovis in experimental model, mirrors Mincle expression

  8. Clecsf8-/- mice exhibit higher bacterial burdens and increased mortality upon Mycobacterium tuberculosis infection.

  9. These results suggest that MCL positively regulates Mincle expression through protein-protein interaction via its stalk region, thereby magnifying Mincle-mediated signaling.

  10. Trehalose 6,6'-dimycolate-induced Mincle expression is dependent on Dectin-3-mediated NF-kappaB activation through the CARD9-BCL10-MALT1 complex.

  11. Compared to their respective homodimers, Dectin-3 and Dectin-2 heterodimers bound alpha-mannans more effectively, leading to potent inflammatory responses against fungal infections.

  12. Clec4d(-/-) neutrophils did not exhibit any defect in bacterial clearance

  13. These results suggest that Clec4d is an FcRgamma-coupled activating receptor that mediates the adjuvanticity of trehalose-6,6'-dimycolate.

  14. The genomic organization of the MCL gene and the sequence of the promoter region were determined

CLEC4D Antigen Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4D

  • C-type lectin domain family 4 member D (CLEC4D) antibody
  • C-type lectin domain family 4 member D (LOC611536) antibody
  • C-type lectin domain family 4, member d (Clec4d) antibody
  • C-type lectin domain family 4, member D (Clec4d) antibody
  • CLEC-6 antibody
  • CLEC4D antibody
  • CLEC6 antibody
  • Clecsf8 antibody
  • Mcl antibody
  • Mpcl antibody

Protein level used designations for CLEC4D

C-type lectin domain family 4, member D , C-type lectin domain family 4 member D , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8 , C-type lectin receptor , C-type lectin superfamily member 8 , C-type lectin-like receptor 6 , macrophage C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8 , C-type lectin, superfamily member 8 , macrophage-restricted C-type lectin

GENE ID SPECIES
473405 Pan troglodytes
611536 Canis lupus familiaris
616646 Bos taurus
338339 Homo sapiens
17474 Mus musculus
362432 Rattus norvegicus
Selected quality suppliers for anti-CLEC4D (CLEC4D) Antibodies
Did you look for something else?