CLEC4D antibody (PE)

Catalog No. ABIN7505926

Product Details anti-CLEC4D Antibody (PE)

Target: CLEC4D (C-Type Lectin Domain Family 4, Member D (CLEC4D))

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC4D antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purpose: Anti-Hu CD368 PE

Specificity: The mouse monoclonal antibody 9B9 recognizes an extracellular epitope of CD368, a type II transmembrane protein of C lectin family, expressed mainly on monocytes and neutrophils.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: CD368 ectodomain fused with human Fc

Clone: 9B9

Isotype: IgG2b kappa

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for CLEC4D

Target: CLEC4D (C-Type Lectin Domain Family 4, Member D (CLEC4D))

Alternative Name: CD368 (CLEC4D Products)

Synonyms: CLEC4D antibody, CLEC-6 antibody, CLEC6 antibody, CLECSF8 antibody, MCL antibody, MPCL antibody, Clecsf8 antibody, Mpcl antibody, mcl antibody, Mcl antibody, C-type lectin domain family 4 member D antibody, C-type lectin domain family 4, member d antibody, C-type lectin domain family 4, member D antibody, CLEC4D antibody, LOC611536 antibody, Clec4d antibody

Background: C-type lectin domain family 4 member D,CD368 is an approximately 25-30 kDa C-type lectin, which serves as one of pattern recognition receptors of the innate immune system. It recognizes pathogen-associated molecular patterns of bacteria and fungi, such as alpha-mannans or trehalose 6,6´-dimycolate, and transfers the signal downstream using associated Fc receptor gamma chain. CD368 is expressed on neutrophils, monocytes, and on some populations of blood dendritic cells, but it decreases during differentiation of monocytes into dendritic cells or macrophages. Increased expression can be induced by IFN-gamma, TNF-alpha, IL-6, and IL-10. CD368 triggering leads to driving of antigen-presenting cells maturation and to promotion of T cell differentiation into Th1 and Th17.,CLEC6, CLEC4D, dectin 3, MCL, MPCL

Gene ID: 338339

UniProt: Q8WXI8