anti-C-Type Lectin Domain Family 4, Member E (CLEC4E) Antibodies

CLEC4E encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC4E Kits (12) and CLEC4E Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC4E 26253 Q9ULY5
CLEC4E 56619 Q9R0Q8
CLEC4E 450223 Q67EQ1
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Top anti-CLEC4E Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 0.1 mL 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB CLEC4E monoclonal antibody (M08), clone 2D12. Western Blot analysis of CLEC4E expression in K-562. Western Blot detection against Immunogen (49.83 KDa) . 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western blot testing of human samples with CLEC4E antibody at 2ug/ml. 100 μg 2 to 3 Days
$328.90
Details
Human Mouse Un-conjugated ELISA, IF, IHC (p), WB Immunofluorescence of human HeLa cells stained with monoclonal CLEC4E monoclonal antibody, clone AT16E3  (1 : 500) with Texas Red (Red). Nucleus was stained by Hoechst 33342 (Blue). Cell lysates of HeLa (35 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with CLEC4E monoclonal antibody, clone AT16E3  (1 : 1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 100 μL 11 to 12 Days
$356.00
Details
Human Mouse Un-conjugated IF, ELISA, WB   50 μL 11 to 14 Days
$639.83
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescent staining of U-251 MG with CLEC4E polyclonal antibody  (Green) shows positivity in cytoplasm. Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with CLEC4E polyclonal antibody  shows strong cytoplasmic positivity in Purkinje cells. 100 μL 11 to 12 Days
$577.33
Details
Human Mouse Un-conjugated WB 100 μg 2 to 3 Days
$280.00
Details
Human Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB   100 μL 11 to 14 Days
$522.50
Details

Top referenced anti-CLEC4E Antibodies

  1. Human Monoclonal CLEC4E Primary Antibody for ELISA, WB - ABIN565251 : Bugarcic, Hitchens, Beckhouse, Wells, Ashman, Blanchard: Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. in Glycobiology 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal CLEC4E Primary Antibody for ELISA, ICC - ABIN4299166 : de Rivero Vaccari, Brand, Berti, Alonso, Bullock, de Rivero Vaccari: Mincle signaling in the innate immune response after traumatic brain injury. in Journal of neurotrauma 2015 (PubMed)

  3. Human Polyclonal CLEC4E Primary Antibody for IF (p), IHC (p) - ABIN1385725 : He, Xu, Li, Guo, Hu, Guo, Tang, Chen, Zhang, Tang, Zhang: Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats. in Stroke 2015 (PubMed)

  4. Human Monoclonal CLEC4E Primary Antibody for FACS, IHC - ABIN2718649 : An, Schneller, Frassetto, Liang, Zhu, Park, Theisen, Hong, Zhou, Rajendran, Levy, Howell, Besin, Presnyak, Sabnis, Murphy-Benenato, Kumarasinghe, Salerno, Mihai, Lukacs, Chandler, Guey, Venditti et al.: Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia. ... in Cell reports 2018 (PubMed)

More Antibodies against CLEC4E Interaction Partners

Human C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. variations at rs10841845 and rs10841847 of CLEC4E gene are associated with increased individual protection against Pulmonary tuberculosis

  2. Mincle has the ability to survey mycolate-derived glycolipids from actinomycetes, distinguishing non-pathogenic (e.g. Rhodococcus spp.) and pathogenic (e.g. Mycobacterium tuberculosis) species on the basis of alpha-chain length.

  3. No association was detected with any of the SNPs analysed and susceptibility to tuberculosis.

  4. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7/8 representing a novel approach to enhance the efficacy of early-life vaccines.

  5. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  6. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  7. CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing

  8. The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus.

  9. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy.

  10. our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury

  11. results suggest that cholesterol crystals are an endogenous ligand for hMincle and that they activate innate immune responses

  12. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK kinase and CARD9 protein.

  13. mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target.

  14. These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle.

  15. Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants.

  16. Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men.

  17. Mincle is a potentially critical player in human B cell responses.

  18. Data indicate an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils.

  19. silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis

  20. Our data suggest that Mincle is induced in adipose tissue macrophages in obesity at least partly through the saturated fatty acid/TLR4/NF-kappaB pathway, thereby suggesting its pathophysiologic role in obesity-induced adipose tissue inflammation.

Mouse (Murine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

  2. Mice deficient in macrophage C-type lectin protein (Mincle) or with selective depletion of tyrosine-protein kinase SYK (Syk) had increased systemic translocation of gut microbiota.

  3. our results indicate that Mincle plays an important role in neutrophil infiltration and suggest that Mincle signaling may provide a therapeutic target for treating sepsis

  4. Mincle activation by cholesterol sulfate causes the secretion of a range of proinflammatory mediators in response to skin damage.

  5. this study shows that mincle inhibits neutrophils and macrophages apoptosis in Aspergillus fumigatus keratitis

  6. Mincle is induced specifically on M1 macrophages, where Mincle-Syk signaling promotes and maintains inflammatory phenotypes of M1 macrophages in acute renal inflammation.

  7. work implicates a novel innate immune driver of Con A hepatitis and, more broadly, suggests a potential role for Mincle in diseases governed by sterile inflammation.

  8. Mincle deletion results in TLR4-mediated inflammation.

  9. Priming by Mincle-deficient dendritic cells (DCs).

  10. Thus, macrophage activation by the corynebacterial cell wall relies on TLR2-driven robust Mincle expression and the cooperative action of both receptors.

  11. this study shows that immune activation in vitro and in vivo by trehalose esters of simple fatty acids requires two acyl chains of length and involves Mincle

  12. Attenuated neutrophil extracellular trap formation in Mincle-/- neutrophils correlates with impaired autophagy activation in vitro and in vivo, whereas reactive oxygen species formation in these neutrophils remained intact.

  13. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  14. this study shows a significant role for Mincle in Pneumocystis modulating host defense during infection

  15. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL (Clecsf8, Clec4d). Conversely, they show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  16. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  17. this paper shows that mycobacterial cell envelope glycolipid TDM modulates TLR2-mediated IL-10 and IL-12p40 responses in macrophages through Mincle, which is, in turn, up-regulated by Mycobacterium bovis BCG

  18. Data show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production.

  19. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye

  20. work shows parallel networks of necroptosis-induced CXCL1 and Mincle signalling that promote macrophage-induced adaptive immune suppression and thereby enable pancreatic ductal adenocarcinoma progression

Cow (Bovine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves

  2. The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-type carbohydrate recognition domain, also constrains the way the binding domains may interact on the surface of macrophages.

  3. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium.

Guinea Pig C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. the function of the guinea pig homologue of Mincle (gpMincle) and MCL (gpMCL). gpMincle directly bound to trehalose-6,6'-dimycolate

CLEC4E Antigen Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4E

  • C-type lectin domain family 4 member E (CLEC4E) antibody
  • C-type lectin domain family 4, member e (Clec4e) antibody
  • C-type lectin domain family 4, member E (Clec4e) antibody
  • C-type lectin domain family 4 member E (LOC611538) antibody
  • C-type lectin domain family 4 member E (Clec4e) antibody
  • C86253 antibody
  • CLEC4E antibody
  • Clecsf9 antibody
  • Mincle antibody

Protein level used designations for CLEC4E

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 , C-type lectin domain family 4 member E , C-type lectin superfamily member 9 , macrophage-inducible C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , C-type lectin, superfamily member 9 , immunoreceptor , C-type lectin domain family 4, member E

GENE ID SPECIES
26253 Homo sapiens
56619 Mus musculus
450223 Rattus norvegicus
514797 Bos taurus
611538 Canis lupus familiaris
722250 Macaca mulatta
735637 Pan troglodytes
100135686 Ovis aries
100350649 Oryctolagus cuniculus
100726838 Cavia porcellus
102121864 Macaca fascicularis
110260748 Sus scrofa
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