anti-C-Type Lectin Domain Family 9, Member A (CLEC9A) Antibodies

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008].. Additionally we are shipping CLEC9A Proteins (7) and CLEC9A Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC9A 232414 Q8BRU4
CLEC9A 283420 Q6UXN8
CLEC9A 502901 D4AD02
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Top anti-CLEC9A Antibodies at antibodies-online.com

Showing 10 out of 81 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis in ZR-75-1 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated FACS, ICC, IHC (fro)   100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded Human kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CLEC9A Polyclonal Antibody, Unconjugated (bs-13620R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded Human colon cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CLEC9A Polyclonal Antibody, Unconjugated (bs-13620R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining. 100 μL 14 to 21 Days
$317.90
Details
Human Mouse APC FACS   100 Tests 11 to 14 Days
$1,079.83
Details
Mouse Rat Un-conjugated FACS, WB   100 μg 11 to 14 Days
$969.83
Details
Human Sheep Un-conjugated IHC, WB   100 μg 11 to 14 Days
$1,145.83
Details
Human Mouse Un-conjugated WB 100 μg 2 to 3 Days
$280.00
Details
Human Rabbit Un-conjugated WB CLEC9A MaxPab rabbit polyclonal antibody. Western Blot analysis of CLEC9A expression in human spleen. CLEC9A MaxPab rabbit polyclonal antibody. Western Blot analysis of CLEC9A expression in mouse kidney. 100 μg 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated WB Western Blot analysis of CLEC9A expression in transfected 293T cell line by CLEC9A MaxPab polyclonal antibody.Lane 1: CLEC9A transfected lysate(26.51 KDa).Lane 2: Non-transfected lysate. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Cy5.5 IF (p)   100 μL 14 to 21 Days
$416.90
Details

Top referenced anti-CLEC9A Antibodies

  1. Mouse (Murine) Monoclonal CLEC9A Primary Antibody for CyTOF, FACS - ABIN4900735 : Li, Ahmet, Sullivan, Brooks, Kent, De Rose, Salazar, Reis e Sousa, Shortman, Lahoud, Heath, Caminschi: Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates. in European journal of immunology 2015 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal CLEC9A Primary Antibody for FACS - ABIN4897678 : Balan, Ollion, Colletti, Chelbi, Montanana-Sanchis, Liu, Vu Manh, Sanchez, Savoret, Perrot, Doffin, Fossum, Bechlian, Chabannon, Bogen, Asselin-Paturel, Shaw, Soos, Caux, Valladeau-Guilemond, Dalod: Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal CLEC9A Primary Antibody for FACS - ABIN4897680 : Breton, Lee, Liu, Nussenzweig: Defining human dendritic cell progenitors by multiparametric flow cytometry. in Nature protocols 2016 (PubMed)

More Antibodies against CLEC9A Interaction Partners

Mouse (Murine) C-Type Lectin Domain Family 9, Member A (CLEC9A) interaction partners

  1. Myosin II-deficient necrotic cells are impaired in their ability to stimulate DNGR-1 or to serve as substrates for Conventional type 1 dendritic cells cross-presentation to CD8(+) T cells.

  2. Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy.

  3. DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic Candida albicans infection without affecting fungal burden.

  4. Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting

  5. DNGR-1 also regulated Trm cell generation.

  6. A specific deletion of DNGR-1 limits the development of atherosclerosis and vascular inflammation.

  7. The authors describe a conformational change that occurs in the neck region of DNGR-1 in a pH- and ionic strength-dependent manner and that controls cross-presentation of dead cell-associated antigens.

  8. Study found presence of DNGR-1 in the brain, providing a potential marker for the study of a specific denditritic brain cell subset

  9. A dependence on DNGR-1 for RSV-specific CD8(+) T-cell responses was observed.

  10. Genetic tracing of DNGR-1 expression history specifically marks cells traditionally ascribed to the dendritic cells lineage, and this restriction is maintained after inflammation.

  11. Clec9A-positive dendritic cells control susceptibility of mice to experimental cerebral malaria.

  12. High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans.

  13. Loss of DNGR-1 impaired the CD8 positive lymphocyte cytotoxic response to vaccinia virus, especially against those virus strains that are most dependent on cross-presentation.

  14. DNGR-1 regulated cross-priming in non-infectious settings such as immunization with antigen-bearing dead cells, as well as in highly immunogenic situations such as infection with herpes simplex virus type 1.

  15. propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.

  16. Data show that targeting of antigen to Clec9A in batf3 null mice produced enhanced antibody responses.

  17. For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.

  18. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.

  19. CLEC9A functions as an activation receptor

  20. DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin of the NK cell receptor group

Human C-Type Lectin Domain Family 9, Member A (CLEC9A) interaction partners

  1. Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy

  2. findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection

  3. Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity.

  4. Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease.

  5. study showsn that the DNGR-1 ligand is preserved from yeast to man and corresponds to the F-actin component of the cellular cytoskeleton; identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity

  6. High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans.

  7. propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.

  8. Data show that CLEC9A is only expressed on immature BDCA3(+) myeloid dendritic cells (mDCs).

  9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.

  10. A population of human dendritic cells (DC) that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function, is characterized.

  11. The paper cited (J Clin Invest. 2008 Jun;118(6):2098-110) is the first characterization of human and mouse CLEC9A (a.k.a DNGR-1)

  12. CLEC9A functions as an activation receptor

  13. analysis of differences between mouse and human Clec9A

  14. CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens

CLEC9A Antigen Profile

Protein Summary

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008

Gene names and symbols associated with CLEC9A

  • C-type lectin domain family 9, member a (Clec9a) antibody
  • C-type lectin domain containing 9A (CLEC9A) antibody
  • C-type lectin domain containing 9A (Clec9a) antibody
  • C-type lectin domain family 9, member A (CLEC9A) antibody
  • 9830005G06Rik antibody
  • DNGR-1 antibody
  • DNGR1 antibody
  • RGD1562513 antibody
  • UNQ9341 antibody

Protein level used designations for CLEC9A

C-type lectin domain family 9 member A , dendritic cell natural killer lectin group receptor 1 , HEEE9341

GENE ID SPECIES
232414 Mus musculus
283420 Homo sapiens
502901 Rattus norvegicus
100726117 Cavia porcellus
101119033 Ovis aries musimon
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