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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (105) and CTCF Kits (11) and many more products for this protein.
Showing 7 out of 8 products:
Human CTCF Protein expressed in Wheat germ - ABIN1350629
Shukla, Kavak, Gregory, Imashimizu, Shutinoski, Kashlev, Oberdoerffer, Sandberg, Oberdoerffer: CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. in Nature 2011
Show all 3 Pubmed References
Human CTCF Protein expressed in Wheat germ - ABIN1350630
Li, Hu, Qiu, Ling, Chen, Wang, Hou, Vu, Hoffman: CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. in Molecular and cellular biology 2008
We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 Proteins) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF (show C11orf9 Proteins) functional interactions in the orchestration of myogenesis.
CCCTC-binding factor CTCF supports the homeostatic maintenance of hematopoietic stem cell (HSCs) pools by sustaining HSC (show FUT1 Proteins) quiescence in a reactive oxygen species ROS (show ROS1 Proteins)-dependent manner.
Authors show that mice devoid of an inducible CTCF binding element, located in the alpha constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR in activated B cells.
The study provides evidence that CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.
Both LDB1 (show LDB1 Proteins) and CTCF are required for enhancer-Car2 (show CA2 Proteins) looping, and the domain of LDB1 (show LDB1 Proteins) contacted by CTCF is necessary to rescue Car2 (show CA2 Proteins) transcription in LDB1 (show LDB1 Proteins)-deficient cells.
CTCF physically associates with Wdr5 (show WDR5 Proteins) and further transcriptionally controls its expression by directly targeting the Wdr5 (show WDR5 Proteins) gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
Nearly half of all DNase (show DNASE2 Proteins) hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 (show RUNX2 Proteins) and/or the chromatin-related CTCF transcription factors.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites.
CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (show BDNF Proteins) and Arc (show NOL3 Proteins) loci.
Findings indicate that CCCTC-binding factor (CTCF)-driven doublesex and mab-3 related transcription factor 2 (show DMRT2 Proteins) protein (TERRA (show DMRT2 Proteins)) transcription acts in cis (show CISH Proteins) to facilitate telomere repeat replication and chromosome stability.
poly(ADP-ribosyl)ated CTCF changes its DNA binding and localisation in a breast cell line which is associated with nucleosome repositioning.
Here, we show that PARP1 (show PARP1 Proteins) and host insulator protein CTCF colocalize at specific sites throughout the EBV genome and provide evidence to suggest that PARP1 (show PARP1 Proteins) acts to stabilize CTCF binding and maintain the open chromatin landscape at the active Cp promoter during type III latency. Further, PARP1 (show PARP1 Proteins) activity is important in maintaining latency type-specific viral gene expression.
HOTTIP cooperates with CTCF to coordinate HOXA gene expression.
CD4 (show CD4 Proteins)(+) T cells showed the greatest increase (threefold) in ORMDL3 (show ORMDL3 Proteins) expression in individuals carrying the asthma-risk alleles, where ORMDL3 (show ORMDL3 Proteins) negatively regulated interleukin-2 (show IL2 Proteins) production. The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus.
Our data reveal that vigilin (show HDLBP Proteins) is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1 (show KCNF1 Proteins)-7 domains of vigilin (show HDLBP Proteins) and zinc-finger domains of CTCF.
This study confirms that haploinsufficiency of CTCF causes distinct clinical features, and that a microdeletion encompassing CTCF could cause a recognisable CTCF deletion syndrome. Perturbed DNA methylation (show HELLS Proteins) at CTCF binding sites, not at imprinted loci, may underlie the pathomechanism of the syndrome.
structural studies show that the sequence-specific interactions between zinc fingers and CTCF-binding sites determine the directionality and conservation of CTCF recognition.
CTCF may be a key factor that contributes to gene co-mutations in cancer.
results support a model in which YY1 (show YY1 Proteins) acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1 (show YY1 Proteins)-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor