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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (107) and CTCF Kits (11) and many more products for this protein.
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Human CTCF Protein expressed in Wheat germ - ABIN1350629
Shukla, Kavak, Gregory, Imashimizu, Shutinoski, Kashlev, Oberdoerffer, Sandberg, Oberdoerffer: CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. in Nature 2011
Show all 3 Pubmed References
Human CTCF Protein expressed in Wheat germ - ABIN1350630
Li, Hu, Qiu, Ling, Chen, Wang, Hou, Vu, Hoffman: CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. in Molecular and cellular biology 2008
We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 Proteins) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF (show C11orf9 Proteins) functional interactions in the orchestration of myogenesis.
CTCF maintains regulatory homeostasis of cancer pathways.
CTCF plays an essential role in otic neurogenesis by modulating histone modification in the Neurog1 (show NEUROG1 Proteins) locus.
CTCF and BORIS (show CTCFL Proteins) cooperate with additional Testis-specific (show AIF1 Proteins) transcriptional regulators to regulate gene expression in developing male gametes.
CCCTC-binding factor CTCF supports the homeostatic maintenance of hematopoietic stem cell (HSCs) pools by sustaining HSC (show FUT1 Proteins) quiescence in a reactive oxygen species ROS (show ROS1 Proteins)-dependent manner.
Authors show that mice devoid of an inducible CTCF binding element, located in the alpha constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR in activated B cells.
The study provides evidence that CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.
Both LDB1 (show LDB1 Proteins) and CTCF are required for enhancer-Car2 (show CA2 Proteins) looping, and the domain of LDB1 (show LDB1 Proteins) contacted by CTCF is necessary to rescue Car2 (show CA2 Proteins) transcription in LDB1 (show LDB1 Proteins)-deficient cells.
CTCF physically associates with Wdr5 (show WDR5 Proteins) and further transcriptionally controls its expression by directly targeting the Wdr5 (show WDR5 Proteins) gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
these results suggest that CTCF participate in DNA damage response via poly(ADP-ribosylation).
Studies suggest that the connection between DNA-binding protein (show UBE2V1 Proteins) CTCF (CTCF), cohesin, chromatin structure, and behavior is important in understanding of the development of behavior in general, and neurodevelopmental disorders in particular [Review].
ID1 (show ID1 Proteins), CTCF and ELK1 (show ELK1 Proteins) may be associated with prostate cancer, and may be potential therapeutic targets for the treatment of this disease.
CTCF promotes HSV-1 lytic transcription by facilitating the elongation of RNA Pol II and preventing silenced chromatin on the viral genome.
These results, together with a prior exomesequencing based study, suggest that CTCF mutations may be involved in the development of ovarian endometriosis.
findings establish for the first time that CTCF is an important regulator of the homologous recombination repair pathway.
Findings indicate that CCCTC-binding factor (CTCF)-driven doublesex and mab-3 related transcription factor 2 (show DMRT2 Proteins) protein (TERRA (show DMRT2 Proteins)) transcription acts in cis (show CISH Proteins) to facilitate telomere repeat replication and chromosome stability.
poly(ADP-ribosyl)ated CTCF changes its DNA binding and localisation in a breast cell line which is associated with nucleosome repositioning.
Here, we show that PARP1 (show PARP1 Proteins) and host insulator protein CTCF colocalize at specific sites throughout the EBV genome and provide evidence to suggest that PARP1 (show PARP1 Proteins) acts to stabilize CTCF binding and maintain the open chromatin landscape at the active Cp promoter during type III latency. Further, PARP1 (show PARP1 Proteins) activity is important in maintaining latency type-specific viral gene expression.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor