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CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites.
Showing 10 out of 89 products:
Human Polyclonal CTCFL Primary Antibody for ICC, IF - ABIN4285064
Hines, Bazarov, Mukhopadhyay, Yaswen: BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas. in PLoS ONE 2010
Show all 3 Pubmed References
Human Polyclonal CTCFL Primary Antibody for ELISA, WB - ABIN151496
Klenova, Morse, Ohlsson, Lobanenkov: The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. in Seminars in cancer biology 2002
Show all 2 Pubmed References
Human Polyclonal CTCFL Primary Antibody for ELISA, WB - ABIN129668
Dougherty, Ichim, Liu, Reznik, Min, Ghochikyan, Agadjanyan, Reznik: Selective apoptosis of breast cancer cells by siRNA targeting of BORIS. in Biochemical and biophysical research communications 2008
Show all 2 Pubmed References
Human Polyclonal CTCFL Primary Antibody for WB - ABIN2775057
Sun, Huang, Nguyen, Bisht, Bar-Sela, Ho, Bradbury, Yu, Cui, Lee, Trepel, Feinberg, Gius: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. in Cancer research 2008
These findings highlight the role of intragenic DNA methylation (show HELLS Antibodies) and DNA binding protein (show UBE2V1 Antibodies) BORIS in cancer-specific splicing and its role in tumorigenesis.
The CCCTC-binding factor (show CTCF Antibodies) plays critical roles in genome topology and function, increased risk of carcinogenicity, and potential of lung cancer-specific mediations. Chromosome reposition in lung cancer can be regulated by CCCTC binding factor (show CTCF Antibodies)
These data provide information on the organization of the BORIS promoter region and gene regulation in normal and cancer cells. In addition, the study proposes that specific alleles of the BORIS-MS2 (show FAR2 Antibodies) region could be used to identify the risk for lung cancer.
the results indicate that the CT antigen BORIS sf6 is specifically expressed in cervical cancer stem-like cells and cancer-initiating cells
BORIS is associated with the cancer stem cell-like traits of human liver cancer cells through the epigenetic regulation of OCT4 (show POU5F1 Antibodies).
In this study, the methylation status of BORIS was tested by methylation specific polymerase chain reaction in human hepatocarcinoma (HCC (show FAM126A Antibodies)) cell lines and 43 pairs of tissue specimens. Frequently demethylation of BORIS in HCC (show FAM126A Antibodies) was significantly higher than that in the paired adjacent non-tumor tissues (P=0.019), and it was correlated with tumor size (P=0.025) and clinical TNM (show ODZ1 Antibodies) stage (P=0.035).
Effectively controlling BORIS/CTCFL levels can inhibit disease establishment and hence can be considered as a potent target for cancer therapy
BORIS is associated with cancer stem cell-enriched populations of several epithelial tumor cells and the different phenotypes depend on the origin of tumor cells.
Data found that BORIS and CTCF (show CTCF Antibodies) expression in low-grade squamous intraepithelial lesions and invasive cervical carcinoma is higher than in normal samples. The possible utility of BORIS and CTCF (show CTCF Antibodies) as biomarkers in cervical neoplasm requires further analysis.
In the first detailed analysis in cancer, a marked loss of CHD8 (show CHD8 Antibodies) expression and increased BORIS/CTCF (show CTCF Antibodies) ratio indicate frequent disruption of CTCF (show CTCF Antibodies) and its effector genes in PCa (show FLVCR1 Antibodies).
The TGFB (show TGFB1 Antibodies) pathway as most affected by embryonic Ctcfl expression.
down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.
Rb2 (show RBL2 Antibodies) coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF (show CTCF Antibodies)) and BORIS in T-antigen-positive but not in T-antigen-negative cells.
These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function.
findings indicate that BORIS-induced expression of TSP50 (show PRSS50 Antibodies) is governed by accessibility and binding of BORIS to the promoter
These findings define transcriptional regulation of CST (Gal3st1 (show GAL3ST1 Antibodies)) expression as a critical role for BORIS in spermatogenesis.
CTCFL and PRMT7 (show PRMT7 Antibodies) may play a role in male germline imprinted gene methylation.
CTCFL/BORIS is a methylation-independent DNA-binding protein (show HSF4 Antibodies) that preferentially binds to the paternal H19 (show NCKAP1 Antibodies) differentially methylated region
DNA damage-induced and ATR (show ATR Antibodies)/Rfx1 (show RFX1 Antibodies)-mediated increase of miR (show MLXIP Antibodies)-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation (show HELLS Antibodies) after radiation exposure.
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, CTCF paralog
, CTCF-like protein
, brother of the regulator of imprinted sites
, cancer/testis antigen 27
, putative high mobility group protein 1-like 1
, putative high mobility group protein B1-like 1
, transcriptional repressor CTCFL
, zinc finger protein CTCF-T
, CCCTC-binding factor (zinc finger protein)-like
, CCCTC-binding factor-like protein
, Brother of the regulator of imprinted sites
, likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL)
, brother of regulator of imprinted sites
, transcriptional repressor CTCFL-like