anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) Antibodies

Human CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) interaction partners

1. The short rare allele of BORIS-MS2 is associated with bladder cancer risk. BORIS expression levels increase with the progression of bladder cancer.

2. BORIS plays a role in epigenetic regulation of SOCS3 gene promoter methylation and histone methylation in hepatocellular carcinoma.

3. aberrant expression of BORIS inhibits apoptosis, promotes proliferation, and attenuates the sensitivity of colorectal cancer cells to 5-FU treatment.

4. These findings highlight the role of intragenic DNA methylation and DNA binding protein BORIS in cancer-specific splicing and its role in tumorigenesis.

5. The CCCTC-binding factor plays critical roles in genome topology and function, increased risk of carcinogenicity, and potential of lung cancer-specific mediations. Chromosome reposition in lung cancer can be regulated by CCCTC binding factor

6. These data provide information on the organization of the BORIS promoter region and gene regulation in normal and cancer cells. In addition, the study proposes that specific alleles of the BORIS-MS2 region could be used to identify the risk for lung cancer.

7. the results indicate that the CT antigen BORIS sf6 is specifically expressed in cervical cancer stem-like cells and cancer-initiating cells

8. BORIS is associated with the cancer stem cell-like traits of human liver cancer cells through the epigenetic regulation of OCT4.

9. In this study, the methylation status of BORIS was tested by methylation specific polymerase chain reaction in human hepatocarcinoma (HCC) cell lines and 43 pairs of tissue specimens. Frequently demethylation of BORIS in HCC was significantly higher than that in the paired adjacent non-tumor tissues (P=0.019), and it was correlated with tumor size (P=0.025) and clinical TNM stage (P=0.035).

10. Effectively controlling BORIS/CTCFL levels can inhibit disease establishment and hence can be considered as a potent target for cancer therapy

11. BORIS is associated with cancer stem cell-enriched populations of several epithelial tumor cells and the different phenotypes depend on the origin of tumor cells.

12. Data found that BORIS and CTCF expression in low-grade squamous intraepithelial lesions and invasive cervical carcinoma is higher than in normal samples. The possible utility of BORIS and CTCF as biomarkers in cervical neoplasm requires further analysis.

13. In the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS/CTCF ratio indicate frequent disruption of CTCF and its effector genes in PCa.

14. Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein.

15. High BORIS transcript variants are associated with laryngeal squamous cell carcinomas.

16. CTCFL/BORIS was amongst the top ranked genes differentially expressed between endometrioid and non-endometrioid tumors, and increasing mRNA level of CTCFL/BORIS was highly significantly associated with poor survival.

17. The serum levels of MAGE-A and BORIS mRNA, as well as let-7b were significantly higher in patients.

18. results provide novel insights into the determinants of NOTCH3 overexpression in cancer cells, by revealing a key role for BORIS as the main mediator of transcriptional deregulation of NOTCH3

19. BORIS is an RNA-binding protein that associates with polysomes.

20. Neither the MTHFR polymorphism, nor CTCFL mutations explain a pattern of sperm hypomethylation at paternally imprinting loci

Mouse (Murine) CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) interaction partners

1. CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes.

2. The TGFB pathway as most affected by embryonic Ctcfl expression.

3. down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.

4. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells.

5. These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function.

6. findings indicate that BORIS-induced expression of TSP50 is governed by accessibility and binding of BORIS to the promoter

7. These findings define transcriptional regulation of CST (Gal3st1) expression as a critical role for BORIS in spermatogenesis.

8. CTCFL and PRMT7 may play a role in male germline imprinted gene methylation.

9. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region

10. DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure.