anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) Antibodies

CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. Additionally we are shipping CTCFL Kits (7) and CTCFL Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CTCFL 140690 Q8NI51
CTCFL 664799 A2APF3
CTCFL 100360757  
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Top anti-CTCFL Antibodies at

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CTCFL Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate CTCFL is supported by BioGPS gene expression data to be expressed in 721_B 100 μL 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB Western blot using  Affinity Purified anti-BORIS antibody shows detection of a predominant band corresponding to BORIS in human tissue lysates (arrowhead).   Lane 1 contains lysate from human prostate tissue.  Lane 2 contains lysate from human spleen tissue.  A predominant band at ~75 kDa is observed.  Molecular weight estimation was made by comparison to prestained MW markers as indicated. 100 μg 5 to 7 Days
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Chimpanzee Rabbit Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of BORIS staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of BORIS expression in Jurkat (A), Hela (B), mouse heart (C), rat testis (D) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
Human Rabbit Un-conjugated ChIP-seq, ChIP, WB Boris / CTCFL antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from human testis and 2 µl of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 20 million sequence tags were mapped to identify Boris / CTCFL binding sites. The image shows binding across a region of chromosome 7. You can view the complete data set in the UCSC Genome Browser, starting at this specific location, here. BORIS / CTCFL antibody (pAb) tested by Western blot. Whole cell extract (10 μg per lane) from HEK293T cells transfected with either vector alone (lanes 1 and 3), with a FLAG-tagged human BORIS expression vector (lanes 2 and 4) or mouse testis nuclear extract (30 μg, lane 5) was probed with either BORIS / CTCFL antibody at 1:2,000 (lanes 1 and 2) or 1:500 (lane 5) or anti-FLAG tag (lanes 3 and 4). 100 μL 1 to 2 Days
Human Rabbit Un-conjugated IF, IHC, WB 100 μL 11 to 13 Days

Top referenced anti-CTCFL Antibodies

  1. Human Polyclonal CTCFL Primary Antibody for ELISA, WB - ABIN129668 : Dougherty, Ichim, Liu, Reznik, Min, Ghochikyan, Agadjanyan, Reznik: Selective apoptosis of breast cancer cells by siRNA targeting of BORIS. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal CTCFL Primary Antibody for ICC, IF - ABIN4285064 : Hines, Bazarov, Mukhopadhyay, Yaswen: BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas. in PLoS ONE 2010 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal CTCFL Primary Antibody for ELISA, WB - ABIN151496 : Klenova, Morse, Ohlsson, Lobanenkov: The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. in Seminars in cancer biology 2002 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal CTCFL Primary Antibody for WB - ABIN2775057 : Sun, Huang, Nguyen, Bisht, Bar-Sela, Ho, Bradbury, Yu, Cui, Lee, Trepel, Feinberg, Gius: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. in Cancer research 2008 (PubMed)

More Antibodies against CTCFL Interaction Partners

Human CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) interaction partners

  1. Discovering a binary CTCF code with a little help from BORIS

  2. The short rare allele of BORIS-MS2 is associated with bladder cancer risk. BORIS expression levels increase with the progression of bladder cancer.

  3. BORIS plays a role in epigenetic regulation of SOCS3 gene promoter methylation and histone methylation in hepatocellular carcinoma.

  4. aberrant expression of BORIS inhibits apoptosis, promotes proliferation, and attenuates the sensitivity of colorectal cancer cells to 5-FU treatment.

  5. These findings highlight the role of intragenic DNA methylation and DNA binding protein BORIS in cancer-specific splicing and its role in tumorigenesis.

  6. The CCCTC-binding factor plays critical roles in genome topology and function, increased risk of carcinogenicity, and potential of lung cancer-specific mediations. Chromosome reposition in lung cancer can be regulated by CCCTC binding factor

  7. These data provide information on the organization of the BORIS promoter region and gene regulation in normal and cancer cells. In addition, the study proposes that specific alleles of the BORIS-MS2 region could be used to identify the risk for lung cancer.

  8. the results indicate that the CT antigen BORIS sf6 is specifically expressed in cervical cancer stem-like cells and cancer-initiating cells

  9. BORIS is associated with the cancer stem cell-like traits of human liver cancer cells through the epigenetic regulation of OCT4.

  10. In this study, the methylation status of BORIS was tested by methylation specific polymerase chain reaction in human hepatocarcinoma (HCC) cell lines and 43 pairs of tissue specimens. Frequently demethylation of BORIS in HCC was significantly higher than that in the paired adjacent non-tumor tissues (P=0.019), and it was correlated with tumor size (P=0.025) and clinical TNM stage (P=0.035).

  11. Effectively controlling BORIS/CTCFL levels can inhibit disease establishment and hence can be considered as a potent target for cancer therapy

  12. BORIS is associated with cancer stem cell-enriched populations of several epithelial tumor cells and the different phenotypes depend on the origin of tumor cells.

  13. Data found that BORIS and CTCF expression in low-grade squamous intraepithelial lesions and invasive cervical carcinoma is higher than in normal samples. The possible utility of BORIS and CTCF as biomarkers in cervical neoplasm requires further analysis.

  14. In the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS/CTCF ratio indicate frequent disruption of CTCF and its effector genes in PCa.

  15. Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein.

  16. High BORIS transcript variants are associated with laryngeal squamous cell carcinomas.

  17. CTCFL/BORIS was amongst the top ranked genes differentially expressed between endometrioid and non-endometrioid tumors, and increasing mRNA level of CTCFL/BORIS was highly significantly associated with poor survival.

  18. The serum levels of MAGE-A and BORIS mRNA, as well as let-7b were significantly higher in patients.

  19. results provide novel insights into the determinants of NOTCH3 overexpression in cancer cells, by revealing a key role for BORIS as the main mediator of transcriptional deregulation of NOTCH3

  20. BORIS is an RNA-binding protein that associates with polysomes.

Mouse (Murine) CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) interaction partners

  1. CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes.

  2. The TGFB pathway as most affected by embryonic Ctcfl expression.

  3. down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.

  4. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells.

  5. These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function.

  6. findings indicate that BORIS-induced expression of TSP50 is governed by accessibility and binding of BORIS to the promoter

  7. These findings define transcriptional regulation of CST (Gal3st1) expression as a critical role for BORIS in spermatogenesis.

  8. CTCFL and PRMT7 may play a role in male germline imprinted gene methylation.

  9. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region

  10. DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure.

CTCFL Antigen Profile

Protein Summary

CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CTCFL

  • CCCTC-binding factor like (CTCFL) antibody
  • CCCTC-binding factor (zinc finger protein)-like (Ctcfl) antibody
  • CCCTC-binding factor like (Ctcfl) antibody
  • Boris antibody
  • CT27 antibody
  • CTCF-T antibody
  • CTCFL antibody
  • dJ579F20.2 antibody
  • HMGB1L1 antibody
  • OTTMUSG00000016680 antibody

Protein level used designations for CTCFL

BORIS-like protein , CTCF paralog , CTCF-like protein , HMG-1L1 , brother of the regulator of imprinted sites , cancer/testis antigen 27 , putative high mobility group protein 1-like 1 , putative high mobility group protein B1-like 1 , transcriptional repressor CTCFL , zinc finger protein CTCF-T , CCCTC-binding factor (zinc finger protein)-like , CCCTC-binding factor-like protein , BORIS , Brother of the regulator of imprinted sites , likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL) , brother of regulator of imprinted sites , transcriptional repressor CTCFL-like

140690 Homo sapiens
458360 Pan troglodytes
477271 Canis lupus familiaris
664799 Mus musculus
100079649 Ornithorhynchus anatinus
100144618 Bos taurus
100360757 Rattus norvegicus
100475700 Ailuropoda melanoleuca
701500 Macaca mulatta
100126237 Sus scrofa
100435120 Pongo abelii
100583303 Nomascus leucogenys
100618914 Monodelphis domestica
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