CD209 Molecule Proteins (CD209)

CD209 encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages.

list all proteins Gene Name GeneID UniProt
Human CD209 CD209 30835 Q9NNX6
Mouse CD209 CD209 170786 Q91ZX1
Rat CD209 CD209 688951  
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Top CD209 Molecule Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Primates His tag   1 mg Log in to see 60 to 71 Days
Yeast REACT_Green monkey His tag   1 mg Log in to see 60 to 71 Days
Yeast Macaca nemestrina His tag   1 mg Log in to see 60 to 71 Days
Yeast Rhesus Monkey His tag   1 mg Log in to see 60 to 71 Days
Yeast Pongo pygmaeus His tag   1 mg Log in to see 60 to 71 Days
Yeast Chimpanzee His tag   1 mg Log in to see 60 to 71 Days
Wheat germ Human Un-conjugated   10 μg Log in to see 11 to 12 Days

More Proteins for CD209 Molecule (CD209) Interaction Partners

Human CD209 Molecule (CD209) interaction partners

  1. The DC-SIGN -336G/A polymorphism significantly affects dengue hemorrhagic fever and dengue fever incidence with the effect more pronounced in certain analyzed patient subgroups (Meta-Analysis).

  2. The results suggest that DC-SIGN SNPs rs7252229, rs4804803, and rs735240 may influence nasopharyngeal carcinoma risk in the Chinese population.

  3. Polymorphism of CD209 and TLR3 (show TLR3 Proteins) genes in populations of North Eurasia

  4. searched for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Delta 32) with the human predisposition to development of various clinical presentations of tick-borne encephalitis

  5. These results show that DC-SIGN and TLR-4 (show TLR4 Proteins) interactions regulate inflammatory responses in renal tubular epithelial cells and participate in AKI pathogenesis.

  6. 1,25(OH)2D3 suppressed the DCSIGN expression in Mycobacterium tuberculosis infected onocytes/macrophages.

  7. Studied the association of CD209 promoter haplotypes with risk of HIV-1 infection in a cohort of Spanish male intravenous drug users (IDU) infected with hepatitis C virus (HCV).

  8. Upon gp120 (show ITIH4 Proteins) binding to DC-SIGN, cellular NF-kappaB (show NFKB1 Proteins) signaling was triggered, leading to the induction of matrix metalloproteinases, which subsequently degraded tight junction proteins and disrupted the blood-retinal barrier integrity.

  9. This study showed that N-glycans on the Gc and Gn surface glycoproteins redundantly support Rift Valley Fever Virus infection via DC-SIGN.

  10. Ligand-driven triggering of TLR-3 (show TLR3 Proteins), -4, NOD2, and DC-SIGN, despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells.

Cow (Bovine) CD209 Molecule (CD209) interaction partners

  1. The development and use of CD209 to characterize the phenotype of CD209 expressing cells in bovine blood using flow cytometry is reported.

  2. a DC-SIGN-like molecule expressed specifically by bovine DC. This molecule may play an important role in the infection of bovine (DC) cells with M. bovis.

Rhesus Monkey CD209 Molecule (CD209) interaction partners

  1. DC-SIGN+ cells showed a clear differential distribution in the decidua in the first 2 weeks of pregnancy, being found only adjacent to the implantation site

  2. DC-SIGN expression in mesenteric lymph nodes is significantly downregulated in simian immunodeficiency virus-infected pig-tailed macaques.

Pig (Porcine) CD209 Molecule (CD209) interaction partners

  1. The cloning and characterization of the cDNA and gene encoding porcine DC-SIGN (pDC (show PDC Proteins)-SIGN)is reported. The results will help better understand the biological role(s) of DC-SIGN family in innate immunity during the evolutionary process.

Zebrafish CD209 Molecule (CD209) interaction partners

  1. identification and functional characterization of DC-SIGN/CD209 molecule in zebrafish

Mouse (Murine) CD209 Molecule (CD209) interaction partners

  1. M. scrofulaceum induces a semimature DC phenotype that is characterized by PD-L2 (show PDCD1LG2 Proteins) over-expression and elevated synthesis of IL-10 (show IL10 Proteins), most likely through TLR4 (show TLR4 Proteins) and Raf-1 (show RAF1 Proteins) signaling pathway-dependent DC-SIGN stimulation.

  2. results suggested that podocytes in lupus nephritis can exert dendritic cell-like function through their expression of DC-SIGN, which may be involved in immune and inflammatory responses of renal tissues

  3. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 (show CD209B Proteins) to simultaneously bind both immune glycoproteins and microbial polysaccharide components.

  4. Data suggest that serum amyloid P (SAP (show APCS Proteins)) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP (show CRP Proteins)), and that DC-SIGN is a target for antifibrotics.

  5. Intestinal enterocytes regulate tissue-associated immune compartments under the control of DC-SIGN in inflammatory bowel disease.

  6. In vivo T cell activation induces the formation of CD209(+) PDL-2 (show PDCD1LG2 Proteins)(+) dendritic cells.

  7. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis.

  8. CD209a is activated in macrophages by LECT2 (show LECT2 Proteins).

  9. The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells

  10. interactions between the CRD (show CRX Proteins) of DC-SIGN and the extracellular matrix and/or cis (show CISH Proteins) interactions with transmembrane scaffolding protein(s) play an essential role in organizing these microdomains

CD209 Molecule (CD209) Protein Profile

Protein Summary

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332\; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CD209 Molecule Proteins (CD209)

  • CD209 molecule (CD209)
  • CD209 molecule (cd209)
  • CD209a antigen (Cd209a)
  • CD209 antigen-like protein D (LOC100529184)
  • CD209c molecule (Cd209c)
  • CD209 antigen (LOC100460708)
  • CD209 antigen (LOC105484282)
  • Cd209 protein
  • CDSIGN protein
  • CIRE protein
  • CLEC4L protein
  • CLEC4M protein
  • DC-SIGN protein
  • DC-SIGN1 protein
  • Dcsign protein
  • si:ch211-224h1.3 protein
  • SIGN-R1 protein
  • SIGNR5 protein

Protein level used designations for CD209 Molecule Proteins (CD209)

C-type lectin domain family 4 member L , C-type lectin domain family 4, member L , CD209 antigen , HIV gpl20-binding protein , dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin , CD209-like protein , DC-SIGN1 , dendritic cell-specific ICAM-3 grabbing non-integrin , C-type lectin domain family 4, member M , DC-SIGN protein , putative mannose-binding C-type lectin , CD209 antigen-like protein A , dendritic cell-specific ICAM-3-grabbing non-integrin , CD209 , CD209 antigen-like protein C , CD209c antigen , Dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific ICAM-3 grabbing nonintegrin

30835 Homo sapiens
100136662 Oncorhynchus mykiss
450160 Pan troglodytes
485000 Canis lupus familiaris
513266 Bos taurus
574211 Macaca mulatta
100170134 Sus scrofa
100334918 Danio rerio
100462978 Felis catus
170786 Mus musculus
100529184 Oryzias latipes
688951 Rattus norvegicus
100460708 Pongo abelii
105484282 Macaca nemestrina
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