CD68 Molecule Proteins (CD68)

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. Additionally we are shipping CD68 Antibodies (742) and CD68 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD68 12514 P31996
CD68 287435  
CD68 968 P34810
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Top CD68 Proteins at

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells Human Fc Tag The purity of Human CD68 Fc Tag was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue. 50 μg Log in to see 2 to 3 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Human Cells Human Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
HEK-293 Cells Human Fc Tag Human CD68, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 11 Days
Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 20 to 21 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days

CD68 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, , ,
Rat (Rattus) ,
Human , , , , ,
, , , ,

More Proteins for CD68 Molecule (CD68) Interaction Partners

Mouse (Murine) CD68 Molecule (CD68) interaction partners

  1. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.

  2. Myeloid osteoclast precursors do not express CD68.

  3. CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.

  4. Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age

  5. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 (show CCR7 Proteins) / CD68 emigration pathway in macrophages

  6. These findings demonstrate a role for CD68 in the function of osteoclasts.

  7. CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking.

  8. Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques.

  9. Macrosialin does not function as an oxLDL receptor on the cell surface.

  10. Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice.

Human CD68 Molecule (CD68) interaction partners

  1. A combination of CD68/CD206 (show MRC1 Proteins) density and HBV-positivity improves further predictive value for post-operative recurrence of hepatocellular carcinoma (HCC (show FAM126A Proteins)) . Quantification of CD68/CD206 (show MRC1 Proteins) macrophages and their distribution can be exploited for better postsurgical management of HCC (show FAM126A Proteins) patients.

  2. Report CD68 over-expression in multinucleated giant cells and mononuclear cells in central and peripheral giant cell granuloma of jaw.

  3. This study shown the CD68 expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.

  4. The results of this study found that the expression levels of Cd68 and Atp5b (show ATP5B Proteins) were significantly correlated with the neurofibrillary tangle burden in the Alzheimer's Disease brain and with their cognition.

  5. Taken together, these results suggested that the changes, including ox-LDL/LDL ratio, CD68(+)/RANK(+) cells number, and the levels of RANKL (show TNFSF11 Proteins) and HMGB1 (show HMGB1 Proteins) in AS patients, favored osteoclastogenesis.

  6. High expression of CD68 is associated with nonalcoholic steatohepatitis.

  7. increased amount of CD68+TAM (show CCNA1 Proteins) in gaps of ductal tumor structures is protective against metastatic spread in regional lymph nodes.

  8. Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (6 of 7 cases), CD163 (show CD163 Proteins) (5 of 5 cases), and PU.1 (3 of 4 cases).

  9. Renal expression of CD68 and the chronicity index are associated with progression to chronic kidney disease in patients with proliferative lupus nephritis.

  10. Results indicate that the expression of FoxP3 (show FOXP3 Proteins) was not significantly associated with survival, and suggest prognostic significance of high CD68 expression in primary central nervous system lymphoma (PCNSL).

CD68 Protein Profile

Protein Summary

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

Gene names and symbols associated with CD68 Molecule Proteins (CD68)

  • CD68 molecule (CD68)
  • CD68 antigen (Cd68)
  • Cd68 molecule (Cd68)
  • GP110 protein
  • LAMP4 protein
  • SCARD1 protein

Protein level used designations for CD68 Molecule Proteins (CD68)

macrosialin , CD68 antigen , macrophage antigen CD68 , scavenger receptor class D, member 1

100344094 Oryctolagus cuniculus
12514 Mus musculus
287435 Rattus norvegicus
968 Homo sapiens
504960 Bos taurus
101099002 Felis catus
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