CD68 Protein (AA 1-319) (His tag)

Catalog No. ABIN7317626

Product Details

Target: CD68 (CD68 Molecule (CD68))

Protein Type: Recombinant

Protein Characteristics: AA 1-319

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This CD68 protein is labelled with His tag.

Purpose: Recombinant Human CD68/Macrosialin Protein (aa 1-319, His Tag)

Sequence: Met 1-Ser 319

Characteristics: A DNA sequence encoding the human CD68 (Met 1-Ser 319) was expressed, with a C-terminal polyhistidine tag.

Purity: > 98 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD68 (CD68 Molecule (CD68))

Alternative Name: CD68/Macrosialin (CD68 Products)

Synonyms: Lamp4 Protein, Scard1 Protein, gp110 Protein, GP110 Protein, LAMP4 Protein, SCARD1 Protein, CD68 molecule Protein, CD68 antigen Protein, Cd68 molecule Protein, CD68 Protein, Cd68 Protein

Background:

Background: Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Synonym: GP110;LAMP4;SCARD1

Molecular Weight: 32.9 kDa