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Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Additionally we are shipping CDC42SE2 Proteins (9) and CDC42SE2 Kits (7) and many more products for this protein.
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Cdc42 is an important regulator of corneal epithelial wound repair. To promote healing, Cdc42 may interact with receptor tyrosine kinase-activated signaling cascades that participate in cell migration and cell-cycle progression.
Recruitment of SPEC2 within Jurkat T cells to the antigen-presenting cell interface occurred following incubation with staphylococcal enterotoxin E superantigen-loaded B cells and colocalized there with F-actin and Cdc42. T cell receptor
haplotypes underlying the SPEC2/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 region are associated with schizophrenia
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity).
CDC42 small effector 2
, CDC42 small effector protein 2
, non-kinase Cdc42 effector protein SPEC2
, small effector of CDC42 protein 2