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Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Proteins (7) and many more products for this protein.
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Human Monoclonal CRTC1 Primary Antibody for ICC, FACS - ABIN969066
Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. in Genes, chromosomes & cancer 2007
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modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 (show RPS6KB1 Antibodies) and MYC (show MYC Antibodies) activity
High TORC1 expression is associated with meningioma and schwannoma.
MECT1-MAML2 (show MAML2 Antibodies) fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma
CRTC1 as new mediator of PGE2 signaling
Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells
revealing neither correlation between the cellular composition and CRTC1-MAML2 (show MAML2 Antibodies) fusions nor presence of CRTC3 (show CRTC3 Antibodies)-MAML2 (show MAML2 Antibodies) fusions in cutaneous hidradenoma
CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.
DNA methylation (show HELLS Antibodies) levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.
Detection of the CRTC1/MAML2 (show MAML2 Antibodies) fusion transcript provides useful information for MEC (show CCL28 Antibodies) diagnosis but is not associated with differences in survival outcomes.
A specific CRTC1-MAMl2 (show MAML2 Antibodies)-induced transcriptional program was identified in mucoepidermoid carcinoma cells.
the HDAC3 (show HDAC3 Antibodies)-N-CoR (show NCOR1 Antibodies) corepressor complex leaves the Fgf1b (show FGF1 Antibodies) promoter and a complex involving the translocated CRTC1, phosphorylated CREB (show CREB1 Antibodies), and histone acetyltransferase (show HAT Antibodies) CBP (show CREBBP Antibodies) induces transient transcription.
Deletion of Raptor (show RPTOR Antibodies) reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.
Three mouse CRTCs (Crtc1, Crtc2 (show CRTC2 Antibodies) and Crtc3 (show CRTC3 Antibodies)) exhibit distinct patterns of 14-3-3 (show YWHAQ Antibodies) binding at three conserved sites corresponding to S70, S171 (show NUMB Antibodies), and S275 (in CRTC2 (show CRTC2 Antibodies)).
The NR2B (show GRIN2B Antibodies)-CREB (show CREB1 Antibodies)-miR212/132-CRTC1-CREB (show CREB1 Antibodies) signal network plays an important role in the regulation of pain.
Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.
Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (show AKT1 Antibodies) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response
Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf (show BDNF Antibodies) and Nr4a1 (show NR4A1 Antibodies)-2. By acting downstream of CRTC1, the HDAC (show HDAC3 Antibodies) inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.
IL-4 (show IL4 Antibodies) signaling co-opts the Akt (show AKT1 Antibodies)-mTORC1 pathway to regulate Acly (show ACLY Antibodies), a key enzyme in acetyl-CoA (show LPCAT1 Antibodies) synthesis, leading to increased histone acetylation and macrophage gene induction.
Upregulation of CRTC1 enhancing CREB (show CREB1 Antibodies)-dependent gene transcription in spinal cord may play an important role in bone cancer pain.
This study demonstrates that TSC1 (show TSC1 Antibodies)- mechanistic target of rapamycin (show FRAP1 Antibodies) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, CREB regulated transcription coactivator 1b
, cAMP-specific 3',5'-cyclic phosphodiesterase 4C
, phosphodiesterase 4C, cAMP-specific b