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Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (87) and and many more products for this protein.
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Pharmacological inhibition of mTORC1 by rapamycin in PHA (show LBR Proteins)-stimulated PBL reduced viral replication to the level found in unstimulated lymphocytes, indicating that mTORC1 activity supports MV replication as a proviral host factor.
SNP located in CRTC1 has been shown in GWAS studies to be significantly associated with the risk of Barrett's esophagus.
This work reveals a regulatory circuit in which SIK1 suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1.
CRTC1 negatively regulates lipogenic gene expression in liver.
findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker
modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 (show RPS6KB1 Proteins) and MYC (show MYC Proteins) activity
High TORC1 expression is associated with meningioma and schwannoma.
MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma
CRTC1 as new mediator of PGE2 signaling
Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells
Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity.
CRTC1 selectively plays protective role against nonalcoholic fatty liver disease development.CRTC1 also mediates anti-lipogenic effects of bile acid signaling, whereas it is negatively regulated by miR (show MLXIP Proteins)-34a.
the HDAC3 (show HDAC3 Proteins)-N-CoR (show NCOR1 Proteins) corepressor complex leaves the Fgf1b (show FGF1 Proteins) promoter and a complex involving the translocated CRTC1, phosphorylated CREB (show CREB1 Proteins), and histone acetyltransferase CBP (show CREBBP Proteins) induces transient transcription.
Deletion of Raptor (show RPTOR Proteins) reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.
Three mouse CRTCs (Crtc1, Crtc2 (show CRTC2 Proteins) and Crtc3 (show CRTC3 Proteins)) exhibit distinct patterns of 14-3-3 (show YWHAQ Proteins) binding at three conserved sites corresponding to S70, S171 (show NUMB Proteins), and S275 (in CRTC2 (show CRTC2 Proteins)).
The NR2B (show GRIN2B Proteins)-CREB (show CREB1 Proteins)-miR212/132-CRTC1-CREB (show CREB1 Proteins) signal network plays an important role in the regulation of pain.
Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.
Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (show AKT1 Proteins) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response
Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf (show BDNF Proteins) and Nr4a1 (show NR4A1 Proteins)-2. By acting downstream of CRTC1, the HDAC (show HDAC3 Proteins) inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.
IL-4 (show IL4 Proteins) signaling co-opts the Akt (show AKT1 Proteins)-mTORC1 pathway to regulate Acly (show ACLY Proteins), a key enzyme in acetyl-CoA (show LPCAT1 Proteins) synthesis, leading to increased histone acetylation and macrophage gene induction.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, CREB regulated transcription coactivator 1b
, cAMP-specific 3',5'-cyclic phosphodiesterase 4C
, phosphodiesterase 4C, cAMP-specific b