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CACNA2D1 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Additionally we are shipping CACNA2D1 Proteins (8) and CACNA2D1 Kits (1) and many more products for this protein.
Showing 10 out of 80 products:
Guinea Pig Monoclonal CACNA2D1 Primary Antibody for FACS, ICC - ABIN266954
Rasmussen, Møller, Knaus, Jensen, Olesen, Jørgensen: Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart. in American journal of physiology. Heart and circulatory physiology 2004
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Cow (Bovine) Polyclonal CACNA2D1 Primary Antibody for WB - ABIN2776091
Stotz, Barr, McRory, Chen, Jarvis, Zamponi: Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit. in The Journal of biological chemistry 2004
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Human Polyclonal CACNA2D1 Primary Antibody for ELISA, WB - ABIN253173
Neely, Hess, Costigan, Keene, Goulas, Langeslag, Griffin, Belfer, Dai, Smith, Diatchenko, Gupta, Xia, Amann, Kreitz, Heindl-Erdmann, Wolz, Ly, Arora, Sarangi, Dan, Novatchkova, Rosenzweig, Gibson et al.: A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. ... in Cell 2010
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Human Polyclonal CACNA2D1 Primary Antibody for ELISA, WB - ABIN190770
Hullin, Matthes, von Vietinghoff, Bodi, Rubio, DSouza, Friedrich Khan, Rottländer, Hoppe, Mohacsi, Schmitteckert, Gilsbach, Bünemann, Hein, Schwartz, Herzig: Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure. in PLoS ONE 2007
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Human Polyclonal CACNA2D1 Primary Antibody for IHC, IHC (p) - ABIN4286770
Han, Du, Zhao, Li, Chen, Zhang, Liu, Suo, Bian, Xing, Zhang: PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells. in Nature communications 2015
we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO (show PCLO Antibodies) and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction
detected a joint effect of SNP and G x E interaction in BMP2 (show BMP2 Antibodies) and CACNA2D1 for depressive state.
All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features.
Compound mutation of CACNA2D1 and RANGRF (show RANGRF Antibodies) genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy.
High prevalence of CACNA2D1, SCN5A (show SCN5A Antibodies), and CACNB2 (show CACNB2 Antibodies) genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.
Functional expression of CACNA2D1 is inhibited by prion protein (show PRNP Antibodies) expression with competition at glycosylphosphatidylinositol.
this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1 (show HNF1A Antibodies).
In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate (show GRIN1 Antibodies) release, yet inhibits this release in wild-type mice.
Results show that mutation of CACNA2D1 gene causes a new varant of SCTS (show ANO6 Antibodies).
CACNA2D1 is a novel Brugada Syndrome susceptibility gene.
data support a model in which small neutral hydrophobic residues facilitate the post-translational cleavage of the CaValpha2delta1 subunit at the predicted membrane interface and further suggest that preventing GPI (show GPI Antibodies) anchoring of CaValpha2delta1 averts its cell-surface expression
these findings provide evidence for a new role of Homer1 (show HOMER1 Antibodies) supporting the regulation of Cav1.2 (show CACNA1C Antibodies) channels by STIM1 (show STIM1 Antibodies).
Based on the impact of both candidate genes,TLR4 (show TLR4 Antibodies) and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
The objective of the present study was to identify polymorphisms of the CACNA2D1 gene, and to analyze associations between these polymorphisms and mastitis in several cattle breeds.
CACNA2D1 gene is one of the potential candidate genes influencing carcass and meat quality traits.
Study identified a critical role for alpha2delta-1 in freeze-lesion-induced developmental cortical malformation pathologies and in mediating the neuroprotective effects of gabapentin (GBP (show PIAS1 Antibodies)). Genetic deletion of alpha2delta-1 did not eliminate GBP's effects on synaptogenesis, suggesting that GBP (show PIAS1 Antibodies) can have alpha2delta-1-independent effects.
Loss of the Ca(2 (show CA2 Antibodies)+) channel alpha2delta-1 subunit function increases the susceptibility for developing diabetes in a sex-dependent manner.
Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 may contribute to individual differences in von Frey filament response.
a TSP4 (show THBS4 Antibodies)/Cavalpha2delta1-dependent pathway activated by TSP4 (show THBS4 Antibodies) or peripheral nerve injury promotes exaggerated presynaptic excitatory input and evoked sensory neuron hyperexcitability and excitatory synaptogenesis.
CaV2.2 (show CACNA1B Antibodies) and alpha2delta-1 are intimately associated at the plasma membrane
These findings suggest that the alpha(2)delta(4) subunit participates in the modulation of L-type Ca(2 (show CA2 Antibodies)+) current regulating neurotransmitter release from photoreceptor terminals
Expression of Cacna2d1 is enhanced in the amygdala in a model of innate anxiety.
This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus
association of calcium channel alpha2/delta subunit 1 and ATP5b (show ATP5B Antibodies) occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients
mechanism of Cavalpha2delta1-mediated spinal sensitization in which elevated Cavalpha2delta1 causes increased pre-synaptic glutamate (show GRIN1 Antibodies) release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli.
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
calcium channel, voltage-dependent, alpha 2/delta subunit 1
, voltage-dependent calcium channel subunit alpha-2/delta-1-like
, calcium channel, L type, alpha 2 polypeptide
, dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
, voltage-dependent calcium channel subunit alpha-2/delta-1
, voltage-gated calcium channel subunit alpha-2/delta-1
, dihydropryridine-sensitive calcium channel alpha-2 subunit
, dihydropyridine-sensitive calcium channel alpha 2
, Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)