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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).. Additionally we are shipping Calpain 2 Proteins (5) and Calpain 2 Kits (3) and many more products for this protein.
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Human Polyclonal Calpain 2 Primary Antibody for WB - ABIN223098
Chou, Huang, Chen, Li: Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2. in Cellular and molecular life sciences : CMLS 2010
indicate that calpain-1 (show CAPN1 Antibodies) and calpain-2 play opposite roles in high increased intraocular pressure-induced ischemic injury
Results indicate that calpain-1 (show CAPN1 Antibodies) and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 Antibodies) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 (show CA1 Antibodies) and CA3 (show CA3 Antibodies), and triggers neurodegenerative cascades.
these findings identify ASAP2 (show ASAP2 Antibodies) as a new target of Selk (show HSP Antibodies)-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.
ENaC (show SCNN1A Antibodies) activity is regulated by calpain-2 proteolysis of MARCKS (show MARCKS Antibodies).
calpains and calpastatin (show CAST Antibodies) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Antibodies)-5HTT (show SLC6A4 Antibodies)(+) strain) PH, were investigated.
Leukocyte calpain-1 (show CAPN1 Antibodies)/calpain-2 deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
These results suggest that TRPV1 (show TRPV1 Antibodies)/Ca(2 (show CA2 Antibodies)+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.
Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.
LOX-1 (show OLR1 Antibodies) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 (show CAPN1 Antibodies) and -2.
Dicer is predominantly a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage of the enzyme by calpain, resulting in loss of function.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).
80 kDa M-calpain subunit
, CANP 2
, calcium-activated neutral proteinase 2
, calpain M-type
, calpain-2 catalytic subunit
, calpain-2 large subunit
, cysteine proteinase
, m-calpain 80 kDa large subunit
, m-calpain large subunit
, calpain 2