anti-Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) Antibodies

CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Additionally we are shipping Caspase 14, Apoptosis-Related Cysteine Peptidase Kits (53) and Caspase 14, Apoptosis-Related Cysteine Peptidase Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CASP14 12365 O89094
CASP14 299587  
CASP14 23581 P31944
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Top anti-Caspase 14, Apoptosis-Related Cysteine Peptidase Antibodies at antibodies-online.com

Showing 10 out of 102 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: Caspase-14 Antibody [ABIN42880636] - Formalin-fixed paraffin-embedded sections from a human ovarian cancer tissue microarray stained for Caspase-14 expression using this antibody at 1:2000. Low (A) and high (B) stage ovarian tumor tissue cores. High magnification from areas of the tissue cores (A1 and B1). Decreased Caspase-14 expression was seen in the high grade, compared to the low grade tumor. Hematoxylin-eosin counterstain. Immunohistochemistry-Paraffin: Caspase-14 Antibody [ABIN42880636] - Tissue sections of human cervix stained using this antibody at 1:2000. A. Normal cervix (squamous epithelium). B. CIN1 (low-grade squamous intraepithelial lesion, mild dysplasia). C. CIN2 (high-grade squamous intraepithelial lesion, moderate dysplasia. D. CIN3 (high-grade squamous intraepithelial lesion; severe dysplasia-carcinoma in situ. In normal cervi, caspase-14 staining was found most in the midzone layer, but was absent from the basal/parabasal cell layer where mitotically active cells are known to reside. This suggests induction of caspase-14 expression with differentiation. Caspase-14 expression declined progressively during malignant transformation as the histologic severity of the cervical atypia advanced from CIN1 to CIN3. Hematoxylin-eosin counterstain. 0.05 mL Log in to see 7 to 9 Days
$347.48
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$265.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Caspase-14 Antibody [NBP2-33906] - Staining of human skin shows strong cytoplasmic and nuclear positivity in keratinocytes. Immunohistochemistry-Paraffin: Caspase-14 Antibody [NBP2-33906] - Skin cancer 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Western Blot: Caspase-14 Antibody [NBP1-03128] - Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with caspase-14 antibody. Immunohistochemistry-Paraffin: Caspase-14 Antibody [NBP1-03128] - Staining of human skin. 0.05 mL Log in to see 7 to 9 Days
$559.35
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; Primary Ab: 1µg/ml Rabbit Anti-Mouse CASP14 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Log in to see 13 to 16 Days
$324.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Skin lysate; Primary Ab: 1µg/ml Rabbit Anti-Mouse CASP14 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Log in to see 13 to 16 Days
$324.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$363.46
Details
Mouse Mouse Un-conjugated FACS, WB 100 μg Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated FACS, ICC, IF, IHC, IHC (p), IP, WB Flow Cytometry: Caspase-14 Antibody (JJ089-01)  - Analysis of A431 cells with Caspase-14 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody Immunocytochemistry/Immunofluorescence: Caspase-14 Antibody (JJ089-01)  - Staining Caspase-14 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 100 μL Log in to see 34 Days
$375.73
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Caspase-14 using COLO whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-Caspase 14, Apoptosis-Related Cysteine Peptidase Antibodies

  1. Dog (Canine) Polyclonal CASP14 Primary Antibody for IHC, IHC (p) - ABIN4288063 : Krajewska, Kim, Shin, Kennedy, Duffy, Wong, Marr, Mikolajczyk, Shabaik, Meinhold-Heerlein, Huang, Banares, Hedayat, Reed, Krajewski: Tumor-associated alterations in caspase-14 expression in epithelial malignancies. in Clinical cancer research : an official journal of the American Association for Cancer Research 2005 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal CASP14 Primary Antibody for IHC (p), IHC - ABIN315654 : Mcheik, Barrault, Pedretti, Garnier, Juchaux, Levard, Morel, Lecron, Bernard: Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts. in Journal of tissue engineering and regenerative medicine 2016 (PubMed)
    Show all 2 Pubmed References

  3. Dog (Canine) Polyclonal CASP14 Primary Antibody for IHC (p), IP - ABIN537403 : Ratovitski: Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation. in FEBS letters 2013 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal CASP14 Primary Antibody for IHC (p), WB - ABIN541182 : Kuida, Lippke, Ku, Harding, Livingston, Su, Flavell: Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal CASP14 Primary Antibody for WB - ABIN1686067 : Sundararajan, White: E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis. in Journal of virology 2001 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Caspase 14, Apoptosis-Related Cysteine Peptidase Interaction Partners

Mouse (Murine) Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) interaction partners

  1. Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  2. caspase-14 overexpression is not the cause of utricle formation

  3. Caspase-14-deficient mice are more prone to the development of parakeratosis.

  4. Mere impairment of filaggrin degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis.

  5. Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.

  6. Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis.

  7. We investigated whether cardiac autonomic control is impaired during sleep in ob/ob mice with morbid obesity caused by congenital leptin deficiency.

  8. processing of caspase 14 in epidermal differentiation

  9. SH2-B dramatically enhanced leptin-stimulated tyrosine phosphorylation of IRS1 and IRS2 in human and mouse cells (this is supposed to be a NEWENTRY for mice--SH2-B).

  10. Caspase-14, but not caspase-3 activation coincides temporally and spatially with embryonic KC differentiation, suggesting a role for caspase-14 in terminally differentiated KC.

  11. The skin of caspase-14-deficient mice was shiny and lichenified, indicating an altered stratum-corneum composition. It contained significantly more alveolar keratohyalin F-granules, the profilaggrin stores.

  12. permeability barrier requirements coordinately drive both the generation of the stratum corneum lipid-enriched extracellular matrix and the transformation of granular cells into corneocytes, in an SP- and Casp-14-dependent manner, signaled by PAR2

Human Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) interaction partners

  1. High CASP14 expression is a marker of breast cancer aggressiveness in association with proliferation, TNBC phenotype, and cancer stemness.

  2. overexpression of S100A7 in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 and caspase-14

  3. caspase-14 contributes to retinal pigment epithelium cell barrier disruption under hyperglycemic conditions.

  4. Caspase-14 was decreased in inflammatory lesions compared to non-lesion in atopic dermatitis. The amount of caspase-14 in the lesions correlated with clinical severity as determined by eczema area and severity index score and the skin barrier functions.

  5. Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  6. partial loss of caspase 14 is not associated with dedifferentiation in neoplastic lesions of the oral mucosa

  7. genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children.

  8. Suggest caspase-14 is a marker of human skin differentiation during development.

  9. Results suggest that caspase-14 may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development.

  10. ceramides, an important structural lipid, stimulate caspase-14 expression, coordinating formation of lipid lamellar membranes with the formation of corneocytes

  11. Caspase-14 might play a significant role in the pathogenesis of diabetic retinopathy by accelerating retinal endothelial and epithelial cells death.

  12. regulation of procaspase-14 maturation during terminal differentiation is a unique two-step process involving KLK7 and an activation intermediate of caspase-14.

  13. genetic polynorphism is associated with the risk of childhood leukemia

  14. A strong association was evident between GATA-3 and caspase-14 expression in preinvasive ductal carcinoma in situ samples, where GATA-3 also displayed prognostic significance

  15. Regulation of caspase 14 levels provides a possible link between impaired skin barrier function and inflammatory reactions in skin diseases such as atopic dermatitis and may offer an explanation to the skin barrier dysfunction in inflamed skin lesions.

  16. Casp-14 overexpression correlated with tumor stage, cell differentiation and lymphovascular involvement, suggesting that casp-14 was associated with tumor cell growth and metastatic potential.

  17. Caspase 14 is a cysteine protease and is inhibited by full-length LEKTI and 5 recombinant fragments of LEKTI to varied extents.

  18. Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody

  19. Results imply that caspase-14 inhibits trophoblast differentiation.

  20. processing of caspase 14 in epidermal differentiation

Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) Antigen Profile

Protein Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Gene names and symbols associated with CASP14

  • caspase 14, apoptosis-related cysteine peptidase (CASP14) antibody
  • caspase 14 (Casp14) antibody
  • caspase 14 (CASP14) antibody
  • caspase-14-like (LOC485601) antibody
  • caspase-14 (LOC780455) antibody
  • CASP14 antibody
  • MICE antibody
  • mini-ICE antibody

Protein level used designations for CASP14

caspase 14 , CASP-14 , caspase-14 , apoptosis-related cysteine protease , caspase 14, apoptosis-related cysteine protease

GENE ID SPECIES
100012133 Monodelphis domestica
12365 Mus musculus
299587 Rattus norvegicus
100101622 Oryctolagus cuniculus
23581 Homo sapiens
100715745 Cavia porcellus
517658 Bos taurus
485601 Canis lupus familiaris
780455 Ovis aries
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