anti-Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1) Antibodies

Human Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1) interaction partners

1. Forced nuclear enrichment of CITED1 in a human WT cell line appears to enhance tumorigenicity, whereas ectopic cytosolic expression confers stem-like properties and an embryonic phenotype.

2. Thus deficiency of Cited1 leads to hyper-activation of Wnt signaling and an exaggerated Wnt phenotype including elevated cell death

3. The CITED1 expression is correlated with lymph node metastasis in patients with colorectal cancer.

4. CITED1 expression remains active across all disease characteristics of Wilms tumor. It is found in the nucleus & cytosol. It is not found in normal kidney.

5. epigenetic regulation is involved in the overexpression of CITED1 in papillary thyroid cancer

6. TOX3 induces transcription in neuron depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.

7. CITED1 functions as a cell cycle-dependent transcriptional cofactor whose activity is regulated by phosphorylation

8. CITED1 could play a role in Wilms' tumor initiation and pathogenesis.

Mouse (Murine) Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1) interaction partners

1. Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.

2. The data indicated that serine phosphorylation at position 79 in the 63-84 domain is associated with PKC activation, and is required for both CITED1 nuclear translocation induced by PTH

3. Loss of placental Cited1 leads to intrauterine organ growth restriction with decreased IGF-I and IGF-II expression and in IR and Igf1r signaling.

4. CBP inactivation in mouse thymocytes leads to lymphoma

5. role for CITED1 in the modulation of transcriptional events mediated by steroid hormone and cytokine signaling pathways

6. The expression pattern of Cited2 overlaps that of Cited1, but its deletion, either alone or in combination with Cited1, does not disrupt epithelial differentiation of the metanephric mesenchyme.

7. These observations suggest that, in addition to an increased gene copy number and upregulation of EGR2 and CITED1, an elevated erbB2 transcript level involves the loss of 14-3-3sigma, which sequesters a key transcriptional regulator of the erbB2 promoter.

8. CITED1 negatively regulates osteoblastic differentiation in vitro and inhibits the cAMP-dependent stimulation of differentiation by intermittent PTH.

9. Renal medullary dysplasia in Cited1 mutant mice is a direct consequence of decreased tissue oxygenation resulting from placental insufficiency.