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CIDEA encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis.
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Human Monoclonal CIDEA Primary Antibody for IP, ELISA - ABIN514417
Puri, Ranjit, Konda, Nicoloro, Straubhaar, Chawla, Chouinard, Lin, Burkart, Corvera, Perugini, Czech: Cidea is associated with lipid droplets and insulin sensitivity in humans. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Polyclonal CIDEA Primary Antibody for ELISA, ICC - ABIN4298761
Rohm, Schäfer, Laurent, Üstünel, Niopek, Algire, Hautzinger, Sijmonsma, Zota, Medrikova, Pellegata, Ryden, Kulyte, Dahlman, Arner, Petrovic, Cannon, Amri, Kemp, Steinberg, Janovska, Kopecky, Wolfrum et al.: An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice. ... in Nature medicine 2016
Cidea, unexpectedly, functions molecularly as an indirect inhibitor of thermogenesis via inhibition of UCP1 (show UCP1 Antibodies) activity.
These data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.
Since Cide-A protein plays a role in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets for these diseases.
The lowest mean relative of the gene expression for CIDE-A was observed in the group of obese patients with aortic aneurysm and lipid disorders
the association of tag-single nucleotide polymorphisms and haplotype structures of the CIDEA gene with obesity in a Han Chinese population, was investigated.
CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma (show MOK Antibodies).
Insulin (show INS Antibodies) regulates CIDEA and CIDEC (show CIDEC Antibodies) expression via PI3K (show PIK3CA Antibodies), and it regulates expression of each protein via Akt1 (show AKT1 Antibodies)/2-and JNK2 (show MAPK9 Antibodies)-dependent pathways, respectively, in human adipocytes.
The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG
CIDEA binds to liver X receptors and regulates their activity in vitro.
These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets
results suggest that FSP27beta negatively regulates CideA-promoted enlargement of lipid droplet size in brown adipocytes.
The authors show demonstrate an essential role of an amphipathic helix in CIDEA, which facilitates embedding in the lipid droplet phospholipid monolayer and binds phosphatidic acid (PA).
Data (including data from studies in knockout mice) suggest Cideb (show CIDEB Antibodies) promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec (show CIDEC Antibodies) promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.
Cidea is highly associated with adiposity and insulin (show INS Antibodies) resistance, whereas Cidec (show CIDEC Antibodies) is related to insulin (show INS Antibodies) sensitivity
data reveal an important role of Cidea in controlling lipid droplet fusion, lipid storage in brown and white adipose tissue, and the development of obesity
maternal diet modulates the age-associated changes in Cidea expression leading to the development of fatty liver
Cidea is a crucial regulator of sebaceous gland lipid storage and sebum lipid secretion in mice.
acts as transcriptional coactivator of C/EBPbeta (show CEBPB Antibodies) in mammary glands to control lipid secretion
Cidea is a critical regulator of free fatty acid-induced apoptosis as a novel downstream target for Foxo1 (show FOXO1 Antibodies) in pancreatic beta-cells
These results suggest that CIDE-A and UCP1 (show UCP1 Antibodies) are regulated by insulin (show INS Antibodies) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
cell death activator CIDE-A
, cell death-inducing DFFA-like effector A
, cell death-inducing DFFA-like effector a
, cell death-inducing DNA fragmentation factor, alpha subunit-like effector A