anti-Ceramide Kinase-Like (CERKL) Antibodies

CERKL was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. Additionally we are shipping Ceramide Kinase-Like Proteins (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CERKL 502640  
CERKL 228094  
CERKL 375298 Q49MI3
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Top anti-Ceramide Kinase-Like Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-CERKL Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human heart WB Suggested Anti-CERKL  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CERKL Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: ACHN cell lysate WB Suggested Anti-CERKL  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: ACHN cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of CERKL staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w Western blot analysis of CERKL expression in MCF7 (A), COLO205 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6266926 staining A549 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis on A549 cell lysate using CERKL Antibody,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from A549 cells, using CERKL Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from A549 cells, using CERKL antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6274389 staining A549 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western Blot: Ceramide Kinase Like Antibody [NBP1-68988] - Titration: 0.2-1 ug/ml, Positive Control: Human heart. 100 μL Log in to see 8 to 11 Days
$488.73
Details

More Antibodies against Ceramide Kinase-Like Interaction Partners

Mouse (Murine) Ceramide Kinase-Like (CERKL) interaction partners

  1. In conclusion, the retina had the highest level of Cerkl mRNA and protein expression, which reached its maximum in the adult retina; and its expression decreased in NeuroD1 knock-out retina.

  2. Cerkl-/- knockdown shows a mild retinal phenotype, with increased levels of cellular stress and apoptosis indicators, and clear signs of functional alteration at the ganglion cell layer, but no detectable morphological changes.

  3. An unexpected multiplicity of CERKL transcriptional start sites (four in each species) plus a high variety of alternative splicing events primarily affecting the 5' half of the gene generate >20 fully validated mRNA isoforms in human and 23 in mouse.

  4. The purpose of this work was to investigate alternative splicing, and the temporal and spatial expression pattern of CERKL in the mouse retina.

  5. This work shows that CerkL does not contribute to phosphorylation of Cer and has no impact on Cer and C16-C1P levels in the retina.

Human Ceramide Kinase-Like (CERKL) interaction partners

  1. Our report indicates that the first diagnostic test for Finnish patients with sporadic or autosomal recessive retinal dystrophy should be a targeted test for founder mutations in the CERKL.

  2. The initial presenting features of CERKL-related retinopathy are distinct and unusual. Recognition of this initial presenting phenotype can facilitate earlier molecular diagnosis and genetic counseling.

  3. pVHL interacts with CERKL and ubiquitinates it for oxygen dependent proteasomal degradation.

  4. CERKL interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway.

  5. An unexpected multiplicity of CERKL transcriptional start sites (four in each species) plus a high variety of alternative splicing events primarily affecting the 5' half of the gene generate >20 fully validated mRNA isoforms in human and 23 in mouse.

  6. Novel mutation in CERKL which encompassed 13 exons is identified in retinitis pigmentosa

  7. Data suggest a functional link between CERKL, a new ceramide kinase homolog, and its nucleolar localization.

  8. Identification of a nuclear localization signal that might be responsible for nucleolar retention of CERKL.

  9. c.238+1G>A is the second reported mutation of CERKL and is a prevalent founder mutation that underlies approximately 33% of autosomal recessive retinal degeneration cases in the Yemenite Jewish population.

  10. This study presents the first genotype-phenotype correlation for persons carrying p.Arg257ter mutation and provides clues for a characteristic phenotype of these mutations among persons with autosomal recessive cases.

  11. This is the third reported mutation in CERKL causing retinal degeneration but is the first report to show that a single amino acid change in CERKL, rather than a null mutation, can cause retinal disease.

  12. Retinitis pigmentosa gene ceramide kinase-like (CERKL) was analyzed to determine CERKL function and contribution to pathogenesis.

  13. The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation.

  14. CERKL mutations are associated with widespread retinal degeneration with prominent maculopathy.

  15. Our data indicate that compound heterozygous mutations of CERKL can cause RP.

Zebrafish Ceramide Kinase-Like (CERKL) interaction partners

  1. Data suggest that zebrafish model is a powerful tool to unveil CERKL contribution to human retinal degeneration.

Cow (Bovine) Ceramide Kinase-Like (CERKL) interaction partners

  1. This study, which is the first to describe the interactions of CERKL with other retinal proteins, links CERKL to proteins involved in the photoresponse and Ca(2+) signaling, providing important clues for future research required in this direction.

Ceramide Kinase-Like (CERKL) Antigen Profile

Protein Summary

This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.

Gene names and symbols associated with CERKL

  • ceramide kinase like (CERKL) antibody
  • ceramide kinase-like (Cerkl) antibody
  • ceramide kinase (LOC408315) antibody
  • ceramide kinase (CERK) antibody
  • ceramide kinase (LOC100566923) antibody
  • ceramide kinase (LOC100645684) antibody
  • ceramide kinase-like (cerkl) antibody
  • ceramide kinase like (Cerkl) antibody
  • GB19002 antibody
  • Gm1958 antibody
  • RGD1561057 antibody
  • RP26 antibody
  • zgc:162213 antibody

Protein level used designations for CERKL

ceramide kinase-like , ceramide kinase-like protein-like , retinitis pigmentosa 26 (autosomal recessive) , ceramide kinase-like protein

GENE ID SPECIES
459793 Pan troglodytes
488430 Canis lupus familiaris
502640 Rattus norvegicus
710256 Macaca mulatta
100027469 Monodelphis domestica
100346364 Oryctolagus cuniculus
100387975 Callithrix jacchus
228094 Mus musculus
408315 Apis mellifera
424120 Gallus gallus
100551089 Meleagris gallopavo
100566923 Anolis carolinensis
100604178 Nomascus leucogenys
100645684 Bombus terrestris
375298 Homo sapiens
100037318 Danio rerio
100718349 Cavia porcellus
100521824 Sus scrofa
100337174 Bos taurus
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