CERKL antibody (N-Term)

Catalog No. ABIN2788233

This Rabbit Polyclonal antibody specifically detects CERKL in WB. It exhibits reactivity toward Human, Rabbit, Horse, Dog, Guinea Pig, Rat, Cow and Pig.

Quick Overview for CERKL antibody (N-Term) (ABIN2788233)

Target: CERKL (Ceramide Kinase-Like (CERKL))

Reactivity: Human, Rabbit, Horse, Dog, Guinea Pig, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CERKL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CERKL Antibody

Binding Specificity: N-Term

Purpose: CERKL Antibody - N-terminal region

Sequence: TLDLINLSED HCDIWFRQFK KILAGFPNRP KSLKILLNPQ SHKKEATQVY

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Pig: 100%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against CERKL. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CERKL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59828-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CERKL

Target: CERKL (Ceramide Kinase-Like (CERKL))

Alternative Name: CERKL

Background:

Background Information: This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.

Gene Name: Ceramide kinase-like

Alternative Symbols: RP26

Protein Name: Ceramide kinase-like protein

Molecular Weight: 59kDa

Gene ID: 375298

NCBI Accession: NP_963842

UniProt: Q49MI3