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Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients.
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Human Polyclonal Chitotriosidase 1 Primary Antibody for ELISA, WB - ABIN4297945
Chien, Lee, Tsai, Chao, Hwu: Reduction in imiglucerase dosage causes immediate rise of chitotriosidase activity in patients with Gaucher disease. in Molecular genetics and metabolism 2010
Human Monoclonal Chitotriosidase 1 Primary Antibody for ELISA, WB - ABIN449966
Berger, Hsieh, Bakele, Marcos, Rieber, Kormann, Mays, Hofer, Neth, Vitkov, Krautgartner, von Schweinitz, Kappler, Hector, Weber, Hartl: Neutrophils express distinct RNA receptors in a non-canonical way. in The Journal of biological chemistry 2012
findings showed chitotriosidase, but not AMCase (show CHIA Antibodies), is expressed in trachea, bronchi & peripheral lung tissue; chitotriosidase gene was identified; results indicate the involvement of chitotriosidase in recurrent airway obstruction is uncertain
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
chitinase 1 (chitotriosidase)