Chitotriosidase 1 antibody (AA 217-466)

Catalog No. ABIN3015833

This Rabbit Polyclonal antibody specifically detects Chitotriosidase 1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Chitotriosidase 1 antibody (AA 217-466) (ABIN3015833)

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chitotriosidase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Chitotriosidase 1 Antibody

Binding Specificity: AA 217-466

Sequence: SWEKVTGHNS PLYKRQEESG AAASLNVDAA VQQWLQKGTP ASKLILGMPT YGRSFTLASS SDTRVGAPAT GSGTPGPFTK EGGMLAYYEV CSWKGATKQR IQDQKVPYIF RDNQWVGFDD VESFKTKVSY LKQKGLGGAM VWALDLDDFA GFSCNQGRYP LIQTLRQELS LPYLPSGTPE LEVPKPGQPS EPEHGPSPGQ DTFCQGKADG LYPNPRERSS FYSCAAGRLF QQSCPTGLVF SNSCKCCTWN

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Chitotriosidase 1

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Alternative Name: CHIT1

Background: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.,CHIT1,CHI3,CHIT,CHITD,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CHIT1

Molecular Weight: 43 kDa/48 kDa/49 kDa/51 kDa

Gene ID: 1118

UniProt: Q13231