anti-Chloride Intracellular Channel 4 (CLIC4) Antibodies

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Additionally we are shipping CLIC4 Proteins (20) and CLIC4 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLIC4 25932 Q9Y696
CLIC4 83718 Q9Z0W7
CLIC4 29876 Q9QYB1
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Top anti-CLIC4 Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, IF, IHC, WB ABIN190810 (0.1µg/ml) staining of human kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN190810 (5ug/ml) staining of min6 cells transiently expressing mouse Clic4. Nuclear counter staining by Hoechst. Data kindly provided by Dr. Virginie Nepote, Lausanne University, Switzerland. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CLIC4 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate 100 μL 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of CLIC4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of CLIC4 expression in Raji (A), HeLa (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, using CLIC4 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CLIC4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with CLIC4 antibody ABIN337111 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-CLIC4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μL 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using CLIC4, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2500. WB Image Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using CLIC4 Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-CLIC4 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1100832 dilution 10 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Guinea Pig Rabbit Un-conjugated IHC, IHC (p), WB Lung, respiratory epithelium Anti-CLIC4 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 100 μL 11 to 14 Days
$639.83
Details

Top referenced anti-CLIC4 Antibodies

  1. Human Polyclonal CLIC4 Primary Antibody for ICC, IF - ABIN4299203 : Lomnytska, Becker, Gemoll, Lundgren, Habermann, Olsson, Bodin, Engström, Hellman, Hellman, Hellström, Andersson, Mints, Auer: Impact of genomic stability on protein expression in endometrioid endometrial cancer. in British journal of cancer 2012 (PubMed)
    Show all 3 Pubmed References

  2. Dog (Canine) Polyclonal CLIC4 Primary Antibody for IF, ELISA - ABIN548172 : Labbus, Henning, Borkham-Kamphorst, Geisler, Berger, Mak, Knüchel, Meyer, Weiskirchen, Henkel: Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions. in Journal of proteomics 2013 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal CLIC4 Primary Antibody for ELISA, ICC - ABIN314274 : Suh, Crutchley, Koochek, Ryscavage, Bhat, Tanaka, Oshima, Fitzgerald, Yuspa: Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)

More Antibodies against CLIC4 Interaction Partners

Human Chloride Intracellular Channel 4 (CLIC4) interaction partners

  1. These results suggest CLIC1 and CLIC4 are promising serum and tissue biomarkers as well as potential therapeutic targets for all EOC subtypes. This justifies development of high throughput serum/plasma biomarker assays to evaluate utility of a biomarker panel consisting of CLIC1, CLIC4 and CA125.

  2. through profilin-1 binding, CLIC4 functions in a RhoA-mDia2-regulated signaling network to integrate cortical actin assembly and membrane protrusion

  3. High CLIC4 expression is associated with Merkel cell polyomavirus positive Merkel cell carcinoma.

  4. Results provide evidence that the G4 structure formed in the CLIC4 promoter region may act as a regulatory element in regulating CLIC4 gene transcription.

  5. CLIC4 and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.

  6. in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls

  7. CLIC1 and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)

  8. CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility.

  9. CLIC4, ERp29, and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer.

  10. This study investigated the proteome modulated by oncogenic KRAS in immortalized airway epithelial cells.

  11. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.

  12. CLIC4 increases tumor cell migration and invasion in a TGF-beta-dependent manner.

  13. In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  14. Our data indicate that CLIC4 protein may be a key element in the apoptotic response to oxidative stress.

  15. These results demonstrate that CLIC4 nuclear translocation is an integral part of the cellular response to starvation.

  16. Reduced CLIC4 expression and nuclear residence detected in cancer cells is associated with the altered redox state of tumor cells and the absence of detectable nuclear CLIC4 in cancers contributes to TGF-beta resistance and enhances tumor development.

  17. CLIC4 may not be responsible for benign familial infantile seizures (BFIS) in a Chinese family affected with BFIS.

  18. Data suggest that CLIC4 is regulated by RhoA to be targeted to the plasma membrane, where it may function not as an inducible chloride channel but rather by displaying Cys-dependent transferase activity toward a yet unknown substrate.

  19. CLIC4 functions to promote endothelial cell proliferation and to regulate endothelial morphogenesis, and is thus involved in multiple steps of in vitro angiogenesis.

  20. CLIC4 is differentially regulated in fibroblasts and its expression contributes to a myofibroblast phenotype

Mouse (Murine) Chloride Intracellular Channel 4 (CLIC4) interaction partners

  1. Results demonstrate that down-regulating CLIC4 inhibit the proliferation and promotes the apoptosis of mouse liver cancer Hca-F cell.

  2. Results indicate CLICs (CLIC1, CLIC4 and CLIC5)-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.

  3. Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 participate in signaling interleukin 1beta secretion and in activation of Nlrp3 inflammasomes; in LPS macrophage activation, Clic1 and Clic4 are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 = chloride intracellular channel 4, mitochondrial; Nlrp3 = NLR family pyrin domain containing 3)

  4. study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta and CLIC4, is a dominant inhibitor of Smad7 and enhances TGF-beta signaling

  5. The findings indicate that CLIC4/CLIC5A-mediated ERM activation is required for maintenance of the glomerular capillary architecture.

  6. CLIC4 is not required for collaterogenesis but is essential for perinatal maturation of nascent collaterals through a mechanism that supports VEGF signaling.

  7. However, the absence of CLIC4 has no significant impact on the extent of functional recovery or fibrosis following acute injury.

  8. Data suggest that compartmentalized expression of chloride intracellular channel 4 (CLIC4) in specific adult tissues and cells provides a focus to explore potential functions of this protein.

  9. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.

  10. These results indicate that CLIC4 participates in skin healing and corneal wound reepithelialization through enhancement of epithelial migration by a mechanism that may involve a compromised TGF-beta pathway.

  11. Data suggest that iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program.

  12. CLIC4 is required for an optimal macrophage response to diverse pathogens. CLIC4-null these findings suggest that CLIC4 is an LPS-induced product that can serve as a positive regulator of LPS signaling

  13. S-nitrosylation governs CLIC4 structure, its association with protein partners, and thus its intracellular distribution

  14. mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53.

  15. mtCLIC is involved in mitochondrial membrane potential generation in mitochondrial DNA-depleted cells.

  16. CLIC4 nuclear translocation is an integral part of the cellular response to stress and may contribute to the initiation of nuclear alterations that are associated with apoptosis.

  17. CLIC4 plays a critical role in angiogenesis by supporting acidification of vacuoles along the cell-hollowing tubulogenic pathway.

  18. These results newly identify Schnurri-2 and CLIC4 as modifiers of TGF-beta signalling through their stabilization of p-Smad2 and 3 in the nucleus.

  19. CLIC4 specifies native collateral formation, exerting influences upstream of hypoxia-inducible factor-1alpha-VEGF signaling

CLIC4 Antigen Profile

Protein Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family\; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).

Gene names and symbols associated with CLIC4

  • chloride intracellular channel 4 (CLIC4) antibody
  • chloride intracellular channel 4 (Clic4) antibody
  • chloride intracellular channel 4 (clic4) antibody
  • chloride intracellular channel 4 (mitochondrial) (Clic4) antibody
  • chloride intracellular channel 4 S homeolog (clic4.S) antibody
  • cb142 antibody
  • CLIC4 antibody
  • CLIC4L antibody
  • D0Jmb3 antibody
  • DKFZp459A0325 antibody
  • H1 antibody
  • huH1 antibody
  • mc3s5 antibody
  • MGC89006 antibody
  • mtCLIC antibody
  • p64H1 antibody
  • TU-74 antibody
  • wu:fb33c05 antibody
  • wu:fc30h10 antibody
  • xclic4 antibody

Protein level used designations for CLIC4

chloride intracellular channel 4 like , chloride intracellular channel protein 4 , intracellular chloride ion channel protein p64H1 , chloride intracellular channel 4 (mitochondrial) , mitochondrial chloride intracellular channel 4 , chloride intracellular channel 4 , Chloride intracellular channel protein 4 , mc3s5/mtCLIC

GENE ID SPECIES
25932 Homo sapiens
83718 Rattus norvegicus
286823 Bos taurus
368255 Danio rerio
419595 Gallus gallus
448566 Xenopus (Silurana) tropicalis
487367 Canis lupus familiaris
712337 Macaca mulatta
749398 Pan troglodytes
100169733 Pongo abelii
100528919 Ictalurus punctatus
29876 Mus musculus
399410 Xenopus laevis
100735560 Cavia porcellus
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