anti-Chloride Intracellular Channel 4 (CLIC4) Antibodies

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Additionally we are shipping CLIC4 Proteins (20) and CLIC4 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLIC4 25932 Q9Y696
CLIC4 83718 Q9Z0W7
CLIC4 29876 Q9QYB1
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Top anti-CLIC4 Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-CLIC4 Antibody Titration: </b>2.5ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated ELISA, WB ABIN190810 (0.1µg/ml) staining of human kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN190810 (5ug/ml) staining of min6 cells transiently expressing mouse Clic4. Nuclear counter staining by Hoechst. Data kindly provided by Dr. Virginie Nepote, Lausanne University, Switzerland. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of CLIC4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of CLIC4 expression in Raji (A), HeLa (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, using CLIC4 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CLIC4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IHC (p), WB Western blot analysis of anti-CLIC4 Monoclonal Antibody (ABIN387769) in Hela cell line lysates. CLIC4(arrow) was detected using the ascites Mab. Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CLIC4 Antibody (ABIN387769), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: CLIC4 Antibody [NBP1-85574] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunocytochemistry/Immunofluorescence: CLIC4 Antibody [NBP1-85574] - Staining of human cell line A-431 shows positivity in cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 20 to 21 Days
$218.90
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using CLIC4, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with (Red) at 1:2500. WB Image Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Goat Un-conjugated IF, IHC (p), ELISA, WB Human Heart (formalin-fixed, paraffin-embedded) stained with CLIC4 antibody ABIN337111 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 10 to 12 Days
$411.13
Details

CLIC4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CLIC4 Antibodies

  1. Human Polyclonal CLIC4 Primary Antibody for ICC, IF - ABIN4299203 : Lomnytska, Becker, Gemoll, Lundgren, Habermann, Olsson, Bodin, Engström, Hellman, Hellman, Hellström, Andersson, Mints, Auer: Impact of genomic stability on protein expression in endometrioid endometrial cancer. in British journal of cancer 2012 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CLIC4 Primary Antibody for ELISA, ICC - ABIN314274 : Suh, Crutchley, Koochek, Ryscavage, Bhat, Tanaka, Oshima, Fitzgerald, Yuspa: Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)

More Antibodies against CLIC4 Interaction Partners

Human Chloride Intracellular Channel 4 (CLIC4) interaction partners

  1. CLIC4 and Ihh (show IHH Antibodies) could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.

  2. in malignant pleural mesothelioma, the gene expressions of CLIC3 (show CLIC3 Antibodies) and CLIC4 were significantly increased compared to controls

  3. CLIC1 (show CLIC1 Antibodies) and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)

  4. CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility.

  5. CLIC4, ERp29 (show ERP29 Antibodies), and Smac/DIABLO (show DIABLO Antibodies) integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer.

  6. This study investigated the proteome modulated by oncogenic KRAS in immortalized airway epithelial cells.

  7. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.

  8. CLIC4 increases tumor cell migration and invasion in a TGF-beta (show TGFB1 Antibodies)-dependent manner.

  9. In addition to CLIC1 (show CLIC1 Antibodies) and TPM1 (show TPM1 Antibodies), which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2 (show TPM2 Antibodies), TPM3 (show TPM3 Antibodies), and TPM4 (show TPM4 Antibodies) were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  10. Our data indicate that CLIC4 protein may be a key element in the apoptotic response to oxidative stress.

Mouse (Murine) Chloride Intracellular Channel 4 (CLIC4) interaction partners

  1. Results indicate CLICs (CLIC1 (show CLIC1 Antibodies), CLIC4 and CLIC5 (show CLIC5 Antibodies))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 (show NLRP3 Antibodies) activation.

  2. Data, including data from studies in primary cells from knockout mice, suggest Clic1 (show CLIC1 Antibodies) and Clic4 participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (show NLRP3 Antibodies) inflammasomes; in LPS (show TLR4 Antibodies) macrophage activation, Clic1 (show CLIC1 Antibodies) and Clic4 are translocated to nucleus/cell membranes. (Clic1 (show CLIC1 Antibodies) = chloride intracellular channel 1 (show CLIC1 Antibodies); Clic4 = chloride intracellular channel 4, mitochondrial; Nlrp3 (show NLRP3 Antibodies) = NLR family pyrin domain containing 3 (show NLRP3 Antibodies))

  3. study reports an alternately-spliced form of Smad7 (show SMAD7 Antibodies), Smad7Delta, that is induced by TGF-beta (show TGFB1 Antibodies) and CLIC4, is a dominant inhibitor of Smad7 (show SMAD7 Antibodies) and enhances TGF-beta (show TGFB1 Antibodies) signaling

  4. The findings indicate that CLIC4/CLIC5A-mediated ERM (show ETV5 Antibodies) activation is required for maintenance of the glomerular capillary architecture.

  5. CLIC4 is not required for collaterogenesis but is essential for perinatal maturation of nascent collaterals through a mechanism that supports VEGF (show VEGFA Antibodies) signaling.

  6. However, the absence of CLIC4 has no significant impact on the extent of functional recovery or fibrosis following acute injury.

  7. Data suggest that compartmentalized expression of chloride intracellular channel 4 (CLIC4) in specific adult tissues and cells provides a focus to explore potential functions of this protein.

  8. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.

  9. These results indicate that CLIC4 participates in skin healing and corneal wound reepithelialization through enhancement of epithelial migration by a mechanism that may involve a compromised TGF-beta (show TGFB1 Antibodies) pathway.

  10. Data suggest that iNOS (show NOS2 Antibodies)-induced nuclear CLIC4 is an essential part of the macrophage deactivation program.

CLIC4 Antigen Profile

Protein Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family\; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).

Gene names and symbols associated with CLIC4

  • chloride intracellular channel 4 (CLIC4) antibody
  • chloride intracellular channel 4 (Clic4) antibody
  • chloride intracellular channel 4 (clic4) antibody
  • chloride intracellular channel 4 (mitochondrial) (Clic4) antibody
  • chloride intracellular channel 4 S homeolog (clic4.S) antibody
  • cb142 antibody
  • CLIC4 antibody
  • CLIC4L antibody
  • D0Jmb3 antibody
  • DKFZp459A0325 antibody
  • H1 antibody
  • huH1 antibody
  • mc3s5 antibody
  • MGC89006 antibody
  • mtCLIC antibody
  • p64H1 antibody
  • TU-74 antibody
  • wu:fb33c05 antibody
  • wu:fc30h10 antibody
  • xclic4 antibody

Protein level used designations for CLIC4

chloride intracellular channel 4 like , chloride intracellular channel protein 4 , intracellular chloride ion channel protein p64H1 , chloride intracellular channel 4 (mitochondrial) , mitochondrial chloride intracellular channel 4 , chloride intracellular channel 4 , Chloride intracellular channel protein 4 , mc3s5/mtCLIC

GENE ID SPECIES
25932 Homo sapiens
83718 Rattus norvegicus
286823 Bos taurus
368255 Danio rerio
419595 Gallus gallus
448566 Xenopus (Silurana) tropicalis
487367 Canis lupus familiaris
712337 Macaca mulatta
749398 Pan troglodytes
100169733 Pongo abelii
100528919 Ictalurus punctatus
29876 Mus musculus
399410 Xenopus laevis
100735560 Cavia porcellus
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